Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory

Autores
Lompardía, Silvina Laura; Pibuel, Matías Arturo; Díaz, Mariángeles; Poodts, Daniela; Hajos, Silvia Elvira
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cancer is one of the leading causes of death worldwide and has been associated with ageing. Although there are numerous reports that have demonstrated the dual role of hyaluronic acid and senescence induction in cancer prevention and promotion, both players have been linked to ageing in opposite ways. Hyaluronan is recognized for its antiaging role, whereas senescence is associated with ageing. In this review we address these dual roles, showing their interrelation, hypothesizing that the downregulation of senescence mediated by HA would be a key factor in the ambivalent effects described. Likewise, the deforestation allegory aims to explain, through the use of a metaphor, the contradictory yet valid results found in the literature. Considering this background, we propose new strategies for improving tumor therapy. Understanding the biology of these complex diseases and the temporal implication of the different players in dissimilar contexts could bring us closer to the therapeutic improvements needed in the field of oncology.
Fil: Lompardía, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Pibuel, Matías Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Díaz, Mariángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Poodts, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Materia
AGEING
CANCER
HYALURONAN
SENESCENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214733
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegoryLompardía, Silvina LauraPibuel, Matías ArturoDíaz, MariángelesPoodts, DanielaHajos, Silvia ElviraAGEINGCANCERHYALURONANSENESCENCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cancer is one of the leading causes of death worldwide and has been associated with ageing. Although there are numerous reports that have demonstrated the dual role of hyaluronic acid and senescence induction in cancer prevention and promotion, both players have been linked to ageing in opposite ways. Hyaluronan is recognized for its antiaging role, whereas senescence is associated with ageing. In this review we address these dual roles, showing their interrelation, hypothesizing that the downregulation of senescence mediated by HA would be a key factor in the ambivalent effects described. Likewise, the deforestation allegory aims to explain, through the use of a metaphor, the contradictory yet valid results found in the literature. Considering this background, we propose new strategies for improving tumor therapy. Understanding the biology of these complex diseases and the temporal implication of the different players in dissimilar contexts could bring us closer to the therapeutic improvements needed in the field of oncology.Fil: Lompardía, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Pibuel, Matías Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Díaz, Mariángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Poodts, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaOxford Univ Press Inc2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214733Lompardía, Silvina Laura; Pibuel, Matías Arturo; Díaz, Mariángeles; Poodts, Daniela; Hajos, Silvia Elvira; Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory; Oxford Univ Press Inc; Glycobiology; 32; 9; 8-2022; 743-7500959-6658CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/glycob/cwac028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:08Zoai:ri.conicet.gov.ar:11336/214733instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:08.88CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
title Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
spellingShingle Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
Lompardía, Silvina Laura
AGEING
CANCER
HYALURONAN
SENESCENCE
title_short Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
title_full Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
title_fullStr Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
title_full_unstemmed Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
title_sort Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory
dc.creator.none.fl_str_mv Lompardía, Silvina Laura
Pibuel, Matías Arturo
Díaz, Mariángeles
Poodts, Daniela
Hajos, Silvia Elvira
author Lompardía, Silvina Laura
author_facet Lompardía, Silvina Laura
Pibuel, Matías Arturo
Díaz, Mariángeles
Poodts, Daniela
Hajos, Silvia Elvira
author_role author
author2 Pibuel, Matías Arturo
Díaz, Mariángeles
Poodts, Daniela
Hajos, Silvia Elvira
author2_role author
author
author
author
dc.subject.none.fl_str_mv AGEING
CANCER
HYALURONAN
SENESCENCE
topic AGEING
CANCER
HYALURONAN
SENESCENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cancer is one of the leading causes of death worldwide and has been associated with ageing. Although there are numerous reports that have demonstrated the dual role of hyaluronic acid and senescence induction in cancer prevention and promotion, both players have been linked to ageing in opposite ways. Hyaluronan is recognized for its antiaging role, whereas senescence is associated with ageing. In this review we address these dual roles, showing their interrelation, hypothesizing that the downregulation of senescence mediated by HA would be a key factor in the ambivalent effects described. Likewise, the deforestation allegory aims to explain, through the use of a metaphor, the contradictory yet valid results found in the literature. Considering this background, we propose new strategies for improving tumor therapy. Understanding the biology of these complex diseases and the temporal implication of the different players in dissimilar contexts could bring us closer to the therapeutic improvements needed in the field of oncology.
Fil: Lompardía, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Pibuel, Matías Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Díaz, Mariángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Poodts, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
description Cancer is one of the leading causes of death worldwide and has been associated with ageing. Although there are numerous reports that have demonstrated the dual role of hyaluronic acid and senescence induction in cancer prevention and promotion, both players have been linked to ageing in opposite ways. Hyaluronan is recognized for its antiaging role, whereas senescence is associated with ageing. In this review we address these dual roles, showing their interrelation, hypothesizing that the downregulation of senescence mediated by HA would be a key factor in the ambivalent effects described. Likewise, the deforestation allegory aims to explain, through the use of a metaphor, the contradictory yet valid results found in the literature. Considering this background, we propose new strategies for improving tumor therapy. Understanding the biology of these complex diseases and the temporal implication of the different players in dissimilar contexts could bring us closer to the therapeutic improvements needed in the field of oncology.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214733
Lompardía, Silvina Laura; Pibuel, Matías Arturo; Díaz, Mariángeles; Poodts, Daniela; Hajos, Silvia Elvira; Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory; Oxford Univ Press Inc; Glycobiology; 32; 9; 8-2022; 743-750
0959-6658
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214733
identifier_str_mv Lompardía, Silvina Laura; Pibuel, Matías Arturo; Díaz, Mariángeles; Poodts, Daniela; Hajos, Silvia Elvira; Senescence modulation as a key process in the dual role of hyaluronan in cancer: the deforestation allegory; Oxford Univ Press Inc; Glycobiology; 32; 9; 8-2022; 743-750
0959-6658
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/glycob/cwac028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford Univ Press Inc
publisher.none.fl_str_mv Oxford Univ Press Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269943811276800
score 13.13397

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