Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring

Autores
Freitag, Nancy; Zwier, M. V.; Barrientos, Gabriela Laura; Tirado González, Irene; Conrad, Melanie L.; Rose, Matthias; Scherjon, S. A.; Plösch, T.; Blois, Sandra M.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.
Fil: Freitag, Nancy. Medicine University of Berlin; Alemania
Fil: Zwier, M. V.. University of Groningen; Países Bajos
Fil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tirado González, Irene. Medicine University of Berlin; Alemania
Fil: Conrad, Melanie L.. Medicine University of Berlin; Alemania
Fil: Rose, Matthias. Medicine University of Berlin; Alemania
Fil: Scherjon, S. A.. University of Groningen; Países Bajos
Fil: Plösch, T.. University of Groningen; Países Bajos
Fil: Blois, Sandra M.. Medicine University of Berlin; Alemania
Materia
NK cells
Dendritic cells
Placenta
Epigenetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36119
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspringFreitag, NancyZwier, M. V.Barrientos, Gabriela LauraTirado González, IreneConrad, Melanie L.Rose, MatthiasScherjon, S. A.Plösch, T.Blois, Sandra M.NK cellsDendritic cellsPlacentaEpigeneticshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.Fil: Freitag, Nancy. Medicine University of Berlin; AlemaniaFil: Zwier, M. V.. University of Groningen; Países BajosFil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tirado González, Irene. Medicine University of Berlin; AlemaniaFil: Conrad, Melanie L.. Medicine University of Berlin; AlemaniaFil: Rose, Matthias. Medicine University of Berlin; AlemaniaFil: Scherjon, S. A.. University of Groningen; Países BajosFil: Plösch, T.. University of Groningen; Países BajosFil: Blois, Sandra M.. Medicine University of Berlin; AlemaniaNature Publishing Group2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36119Freitag, Nancy; Zwier, M. V.; Barrientos, Gabriela Laura; Tirado González, Irene; Conrad, Melanie L.; et al.; Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring; Nature Publishing Group; Cell Death and Disease; 5; 8-2014; 1-8; e13922041-4889CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/cddis.2014.353info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddis2014353info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165878/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:12:12Zoai:ri.conicet.gov.ar:11336/36119instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:12:12.26CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
title Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
spellingShingle Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
Freitag, Nancy
NK cells
Dendritic cells
Placenta
Epigenetics
title_short Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
title_full Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
title_fullStr Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
title_full_unstemmed Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
title_sort Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
dc.creator.none.fl_str_mv Freitag, Nancy
Zwier, M. V.
Barrientos, Gabriela Laura
Tirado González, Irene
Conrad, Melanie L.
Rose, Matthias
Scherjon, S. A.
Plösch, T.
Blois, Sandra M.
author Freitag, Nancy
author_facet Freitag, Nancy
Zwier, M. V.
Barrientos, Gabriela Laura
Tirado González, Irene
Conrad, Melanie L.
Rose, Matthias
Scherjon, S. A.
Plösch, T.
Blois, Sandra M.
author_role author
author2 Zwier, M. V.
Barrientos, Gabriela Laura
Tirado González, Irene
Conrad, Melanie L.
Rose, Matthias
Scherjon, S. A.
Plösch, T.
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NK cells
Dendritic cells
Placenta
Epigenetics
topic NK cells
Dendritic cells
Placenta
Epigenetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.
Fil: Freitag, Nancy. Medicine University of Berlin; Alemania
Fil: Zwier, M. V.. University of Groningen; Países Bajos
Fil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tirado González, Irene. Medicine University of Berlin; Alemania
Fil: Conrad, Melanie L.. Medicine University of Berlin; Alemania
Fil: Rose, Matthias. Medicine University of Berlin; Alemania
Fil: Scherjon, S. A.. University of Groningen; Países Bajos
Fil: Plösch, T.. University of Groningen; Países Bajos
Fil: Blois, Sandra M.. Medicine University of Berlin; Alemania
description Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36119
Freitag, Nancy; Zwier, M. V.; Barrientos, Gabriela Laura; Tirado González, Irene; Conrad, Melanie L.; et al.; Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring; Nature Publishing Group; Cell Death and Disease; 5; 8-2014; 1-8; e1392
2041-4889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36119
identifier_str_mv Freitag, Nancy; Zwier, M. V.; Barrientos, Gabriela Laura; Tirado González, Irene; Conrad, Melanie L.; et al.; Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring; Nature Publishing Group; Cell Death and Disease; 5; 8-2014; 1-8; e1392
2041-4889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/cddis.2014.353
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddis2014353
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165878/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083270187417600
score 13.22299

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