Pulmonary surfactant in asthma

Autores
Blanco, Odalys; Díaz Reyes, Mercyleidi; Labrada, Alexis; Autilio, Chiara; Pérez Gil, Jesús
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pulmonary surfactant is vital in human respiration. It maintains alveoli and terminal conducting airways open and therefore promotes an efficient gas exchange and low resistance in the airways during breathing dynamics. Lack or dysfunction of the pulmonary surfactant system is associated with severe lung disorders. Surfactant ability to maintain low surface tension at the respiratory air-liquid interface, with subsequent good compliance and low resistance in the airways, is extremely important for asthmatic patients. A growing series of experimental evidence indicates that surfactant dysfunction, either associated with the causes or as a consequence of asthma, can contribute to constriction of airways and exacerbation of asthma. Modulation by surfactant of the innate and induced immune response is also an important element defining propensity, but also the resolution of asthmatic crisis. Limited trials indicate that administration of exogenous therapeutic surfactant may offer favorable pharmacological effects to asthmatic patients, possibly by two different mechanisms. On the one hand, it can restore endogenous surface activity and, on the other hand, properly modulate the immune system. The objective of the present review has been to summarize and update available concepts and evidence that support the relationship between pulmonary surfactant and asthma, with particular attention to the role of pulmonary surfactant in the mechanisms of asthma manifestations as well as in the design of innovative future therapies.
Fil: Blanco, Odalys. Centro Nacional de Sanidad Agropecuaria; Cuba
Fil: Díaz Reyes, Mercyleidi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Labrada, Alexis. No especifíca;
Fil: Autilio, Chiara. Universidad Complutense de Madrid. Facultad de Biología; España
Fil: Pérez Gil, Jesús. Universidad Complutense de Madrid. Facultad de Biología; España
Materia
Pulmonary surfactant
Surface tension
Asthma
Exogenous surfactant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/281297
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/281297
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pulmonary surfactant in asthmaBlanco, OdalysDíaz Reyes, MercyleidiLabrada, AlexisAutilio, ChiaraPérez Gil, JesúsPulmonary surfactantSurface tensionAsthmaExogenous surfactanthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Pulmonary surfactant is vital in human respiration. It maintains alveoli and terminal conducting airways open and therefore promotes an efficient gas exchange and low resistance in the airways during breathing dynamics. Lack or dysfunction of the pulmonary surfactant system is associated with severe lung disorders. Surfactant ability to maintain low surface tension at the respiratory air-liquid interface, with subsequent good compliance and low resistance in the airways, is extremely important for asthmatic patients. A growing series of experimental evidence indicates that surfactant dysfunction, either associated with the causes or as a consequence of asthma, can contribute to constriction of airways and exacerbation of asthma. Modulation by surfactant of the innate and induced immune response is also an important element defining propensity, but also the resolution of asthmatic crisis. Limited trials indicate that administration of exogenous therapeutic surfactant may offer favorable pharmacological effects to asthmatic patients, possibly by two different mechanisms. On the one hand, it can restore endogenous surface activity and, on the other hand, properly modulate the immune system. The objective of the present review has been to summarize and update available concepts and evidence that support the relationship between pulmonary surfactant and asthma, with particular attention to the role of pulmonary surfactant in the mechanisms of asthma manifestations as well as in the design of innovative future therapies.Fil: Blanco, Odalys. Centro Nacional de Sanidad Agropecuaria; CubaFil: Díaz Reyes, Mercyleidi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Labrada, Alexis. No especifíca;Fil: Autilio, Chiara. Universidad Complutense de Madrid. Facultad de Biología; EspañaFil: Pérez Gil, Jesús. Universidad Complutense de Madrid. Facultad de Biología; EspañaElsevier Science2025-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/281297Blanco, Odalys; Díaz Reyes, Mercyleidi; Labrada, Alexis; Autilio, Chiara; Pérez Gil, Jesús; Pulmonary surfactant in asthma; Elsevier Science; European Journal of Pharmacology; 1005; 10-2025; 1-170014-2999CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0014299925008180info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2025.178064info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T09:58:57Zoai:ri.conicet.gov.ar:11336/281297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 09:58:57.482CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pulmonary surfactant in asthma
title Pulmonary surfactant in asthma
spellingShingle Pulmonary surfactant in asthma
Blanco, Odalys
Pulmonary surfactant
Surface tension
Asthma
Exogenous surfactant
title_short Pulmonary surfactant in asthma
title_full Pulmonary surfactant in asthma
title_fullStr Pulmonary surfactant in asthma
title_full_unstemmed Pulmonary surfactant in asthma
title_sort Pulmonary surfactant in asthma
dc.creator.none.fl_str_mv Blanco, Odalys
Díaz Reyes, Mercyleidi
Labrada, Alexis
Autilio, Chiara
Pérez Gil, Jesús
author Blanco, Odalys
author_facet Blanco, Odalys
Díaz Reyes, Mercyleidi
Labrada, Alexis
Autilio, Chiara
Pérez Gil, Jesús
author_role author
author2 Díaz Reyes, Mercyleidi
Labrada, Alexis
Autilio, Chiara
Pérez Gil, Jesús
author2_role author
author
author
author
dc.subject.none.fl_str_mv Pulmonary surfactant
Surface tension
Asthma
Exogenous surfactant
topic Pulmonary surfactant
Surface tension
Asthma
Exogenous surfactant
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pulmonary surfactant is vital in human respiration. It maintains alveoli and terminal conducting airways open and therefore promotes an efficient gas exchange and low resistance in the airways during breathing dynamics. Lack or dysfunction of the pulmonary surfactant system is associated with severe lung disorders. Surfactant ability to maintain low surface tension at the respiratory air-liquid interface, with subsequent good compliance and low resistance in the airways, is extremely important for asthmatic patients. A growing series of experimental evidence indicates that surfactant dysfunction, either associated with the causes or as a consequence of asthma, can contribute to constriction of airways and exacerbation of asthma. Modulation by surfactant of the innate and induced immune response is also an important element defining propensity, but also the resolution of asthmatic crisis. Limited trials indicate that administration of exogenous therapeutic surfactant may offer favorable pharmacological effects to asthmatic patients, possibly by two different mechanisms. On the one hand, it can restore endogenous surface activity and, on the other hand, properly modulate the immune system. The objective of the present review has been to summarize and update available concepts and evidence that support the relationship between pulmonary surfactant and asthma, with particular attention to the role of pulmonary surfactant in the mechanisms of asthma manifestations as well as in the design of innovative future therapies.
Fil: Blanco, Odalys. Centro Nacional de Sanidad Agropecuaria; Cuba
Fil: Díaz Reyes, Mercyleidi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Labrada, Alexis. No especifíca;
Fil: Autilio, Chiara. Universidad Complutense de Madrid. Facultad de Biología; España
Fil: Pérez Gil, Jesús. Universidad Complutense de Madrid. Facultad de Biología; España
description Pulmonary surfactant is vital in human respiration. It maintains alveoli and terminal conducting airways open and therefore promotes an efficient gas exchange and low resistance in the airways during breathing dynamics. Lack or dysfunction of the pulmonary surfactant system is associated with severe lung disorders. Surfactant ability to maintain low surface tension at the respiratory air-liquid interface, with subsequent good compliance and low resistance in the airways, is extremely important for asthmatic patients. A growing series of experimental evidence indicates that surfactant dysfunction, either associated with the causes or as a consequence of asthma, can contribute to constriction of airways and exacerbation of asthma. Modulation by surfactant of the innate and induced immune response is also an important element defining propensity, but also the resolution of asthmatic crisis. Limited trials indicate that administration of exogenous therapeutic surfactant may offer favorable pharmacological effects to asthmatic patients, possibly by two different mechanisms. On the one hand, it can restore endogenous surface activity and, on the other hand, properly modulate the immune system. The objective of the present review has been to summarize and update available concepts and evidence that support the relationship between pulmonary surfactant and asthma, with particular attention to the role of pulmonary surfactant in the mechanisms of asthma manifestations as well as in the design of innovative future therapies.
publishDate 2025
dc.date.none.fl_str_mv 2025-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/281297
Blanco, Odalys; Díaz Reyes, Mercyleidi; Labrada, Alexis; Autilio, Chiara; Pérez Gil, Jesús; Pulmonary surfactant in asthma; Elsevier Science; European Journal of Pharmacology; 1005; 10-2025; 1-17
0014-2999
CONICET Digital
CONICET
url http://hdl.handle.net/11336/281297
identifier_str_mv Blanco, Odalys; Díaz Reyes, Mercyleidi; Labrada, Alexis; Autilio, Chiara; Pérez Gil, Jesús; Pulmonary surfactant in asthma; Elsevier Science; European Journal of Pharmacology; 1005; 10-2025; 1-17
0014-2999
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0014299925008180
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2025.178064
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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