Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies...

Autores: Ponce, Ivana Tamara; Coria Lucero, Cinthia Daiana; Lacoste, Maria Gabriela; Della Vedova, Maria Cecilia; Devia, Cristina Mabel; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Delgado, Silvia Marcela; Anzulovich Miranda, Ana Cecilia
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Age impairs cognitive functions and antioxidant defenses, for example, by increasing oxidative stress and inflammation in the brain. However, to date, there are no reports on the consequences of aging on temporal patterns of lipid and protein oxidation, antioxidant enzymes activity, the endogenous clock, and proinflammatory cytokines in the prefrontal cortex (PFC). Therefore, our objectives were 1) to investigate the endogenous nature of 24-h rhythms of lipid peroxidation, protein carbonyl levels, catalase (CAT) and glutathione peroxidase (GPX) activity as well as retinoic acid-related orphan receptor a (RORa) and tumor necrosis factor alpha (TNF-α) levels, in the rat PFC, and 2) to study the consequences of aging on the circadian organization of these factors in this area. To do that, we used male Holtzman rats, maintained under constant darkness conditions for 15 days before reaching 3- and 22-mo-old, respectively. PFC samples were isolatedevery 4 h under dim-red light for a 24 h period. Our results revealed circadian patterns of antioxidant enzymes activity, oxidative stress, RORa and TNF-α protein levels in the PFC of young rats. The circadian distribution of the rhythms’ acrophases suggests reciprocal communicationamong antioxidant defenses, endogenous clock, and inflammation. Such circadian organization disappears in the PFC of aged rats. Increased oxidative stress modifies the cellular redox environment and, consequently, alters the endogenous clock activity and disrupts the circadianorganization of antioxidant defenses and TNF-α in the PFC. These results might highlight novel chronobiological targets for the design of therapeutic strategies for healthy aging patients.
Fil: Ponce, Ivana Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Coria Lucero, Cinthia Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Della Vedova, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Devia, Cristina Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia: CIRCADIAN RHYTHM
OXIDATIVE STRESS
RETINOIC ACID-RELATED ORPHAN RECEPTOR A
TUMOR NECROSIS FACTOR ALPHA
PREFRONTAL CORTEX
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/266588

Acceder

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network_name_str	CONICET Digital (CONICET)
spelling	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.Ponce, Ivana TamaraCoria Lucero, Cinthia DaianaLacoste, Maria GabrielaDella Vedova, Maria CeciliaDevia, Cristina MabelRamirez, DarioGomez Mejiba, Sandra EstherDelgado, Silvia MarcelaAnzulovich Miranda, Ana CeciliaCIRCADIAN RHYTHMOXIDATIVE STRESSRETINOIC ACID-RELATED ORPHAN RECEPTOR ATUMOR NECROSIS FACTOR ALPHAPREFRONTAL CORTEXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Age impairs cognitive functions and antioxidant defenses, for example, by increasing oxidative stress and inflammation in the brain. However, to date, there are no reports on the consequences of aging on temporal patterns of lipid and protein oxidation, antioxidant enzymes activity, the endogenous clock, and proinflammatory cytokines in the prefrontal cortex (PFC). Therefore, our objectives were 1) to investigate the endogenous nature of 24-h rhythms of lipid peroxidation, protein carbonyl levels, catalase (CAT) and glutathione peroxidase (GPX) activity as well as retinoic acid-related orphan receptor a (RORa) and tumor necrosis factor alpha (TNF-α) levels, in the rat PFC, and 2) to study the consequences of aging on the circadian organization of these factors in this area. To do that, we used male Holtzman rats, maintained under constant darkness conditions for 15 days before reaching 3- and 22-mo-old, respectively. PFC samples were isolatedevery 4 h under dim-red light for a 24 h period. Our results revealed circadian patterns of antioxidant enzymes activity, oxidative stress, RORa and TNF-α protein levels in the PFC of young rats. The circadian distribution of the rhythms’ acrophases suggests reciprocal communicationamong antioxidant defenses, endogenous clock, and inflammation. Such circadian organization disappears in the PFC of aged rats. Increased oxidative stress modifies the cellular redox environment and, consequently, alters the endogenous clock activity and disrupts the circadianorganization of antioxidant defenses and TNF-α in the PFC. These results might highlight novel chronobiological targets for the design of therapeutic strategies for healthy aging patients.Fil: Ponce, Ivana Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Coria Lucero, Cinthia Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Della Vedova, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Devia, Cristina Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaDogu Kampusu Suleyman Demirel University2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266588Ponce, Ivana Tamara; Coria Lucero, Cinthia Daiana; Lacoste, Maria Gabriela; Della Vedova, Maria Cecilia; Devia, Cristina Mabel; et al.; Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.; Dogu Kampusu Suleyman Demirel University; Journal of Cellular Neuroscience and Oxidative Stress; 16; 1; 7-2024; 1183-11942149-7222CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://dergipark.org.tr/en/doi/10.37212/jcnos.1460272info:eu-repo/semantics/altIdentifier/doi/10.37212/jcnos.1460272info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:23Zoai:ri.conicet.gov.ar:11336/266588instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:23.871CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
title	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
spellingShingle	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging. Ponce, Ivana Tamara CIRCADIAN RHYTHM OXIDATIVE STRESS RETINOIC ACID-RELATED ORPHAN RECEPTOR A TUMOR NECROSIS FACTOR ALPHA PREFRONTAL CORTEX
title_short	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
title_full	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
title_fullStr	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
title_full_unstemmed	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
title_sort	Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
dc.creator.none.fl_str_mv	Ponce, Ivana Tamara Coria Lucero, Cinthia Daiana Lacoste, Maria Gabriela Della Vedova, Maria Cecilia Devia, Cristina Mabel Ramirez, Dario Gomez Mejiba, Sandra Esther Delgado, Silvia Marcela Anzulovich Miranda, Ana Cecilia
author	Ponce, Ivana Tamara
author_facet	Ponce, Ivana Tamara Coria Lucero, Cinthia Daiana Lacoste, Maria Gabriela Della Vedova, Maria Cecilia Devia, Cristina Mabel Ramirez, Dario Gomez Mejiba, Sandra Esther Delgado, Silvia Marcela Anzulovich Miranda, Ana Cecilia
author_role	author
author2	Coria Lucero, Cinthia Daiana Lacoste, Maria Gabriela Della Vedova, Maria Cecilia Devia, Cristina Mabel Ramirez, Dario Gomez Mejiba, Sandra Esther Delgado, Silvia Marcela Anzulovich Miranda, Ana Cecilia
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	CIRCADIAN RHYTHM OXIDATIVE STRESS RETINOIC ACID-RELATED ORPHAN RECEPTOR A TUMOR NECROSIS FACTOR ALPHA PREFRONTAL CORTEX
topic	CIRCADIAN RHYTHM OXIDATIVE STRESS RETINOIC ACID-RELATED ORPHAN RECEPTOR A TUMOR NECROSIS FACTOR ALPHA PREFRONTAL CORTEX
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	Age impairs cognitive functions and antioxidant defenses, for example, by increasing oxidative stress and inflammation in the brain. However, to date, there are no reports on the consequences of aging on temporal patterns of lipid and protein oxidation, antioxidant enzymes activity, the endogenous clock, and proinflammatory cytokines in the prefrontal cortex (PFC). Therefore, our objectives were 1) to investigate the endogenous nature of 24-h rhythms of lipid peroxidation, protein carbonyl levels, catalase (CAT) and glutathione peroxidase (GPX) activity as well as retinoic acid-related orphan receptor a (RORa) and tumor necrosis factor alpha (TNF-α) levels, in the rat PFC, and 2) to study the consequences of aging on the circadian organization of these factors in this area. To do that, we used male Holtzman rats, maintained under constant darkness conditions for 15 days before reaching 3- and 22-mo-old, respectively. PFC samples were isolatedevery 4 h under dim-red light for a 24 h period. Our results revealed circadian patterns of antioxidant enzymes activity, oxidative stress, RORa and TNF-α protein levels in the PFC of young rats. The circadian distribution of the rhythms’ acrophases suggests reciprocal communicationamong antioxidant defenses, endogenous clock, and inflammation. Such circadian organization disappears in the PFC of aged rats. Increased oxidative stress modifies the cellular redox environment and, consequently, alters the endogenous clock activity and disrupts the circadianorganization of antioxidant defenses and TNF-α in the PFC. These results might highlight novel chronobiological targets for the design of therapeutic strategies for healthy aging patients. Fil: Ponce, Ivana Tamara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Coria Lucero, Cinthia Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Della Vedova, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Devia, Cristina Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Delgado, Silvia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description	Age impairs cognitive functions and antioxidant defenses, for example, by increasing oxidative stress and inflammation in the brain. However, to date, there are no reports on the consequences of aging on temporal patterns of lipid and protein oxidation, antioxidant enzymes activity, the endogenous clock, and proinflammatory cytokines in the prefrontal cortex (PFC). Therefore, our objectives were 1) to investigate the endogenous nature of 24-h rhythms of lipid peroxidation, protein carbonyl levels, catalase (CAT) and glutathione peroxidase (GPX) activity as well as retinoic acid-related orphan receptor a (RORa) and tumor necrosis factor alpha (TNF-α) levels, in the rat PFC, and 2) to study the consequences of aging on the circadian organization of these factors in this area. To do that, we used male Holtzman rats, maintained under constant darkness conditions for 15 days before reaching 3- and 22-mo-old, respectively. PFC samples were isolatedevery 4 h under dim-red light for a 24 h period. Our results revealed circadian patterns of antioxidant enzymes activity, oxidative stress, RORa and TNF-α protein levels in the PFC of young rats. The circadian distribution of the rhythms’ acrophases suggests reciprocal communicationamong antioxidant defenses, endogenous clock, and inflammation. Such circadian organization disappears in the PFC of aged rats. Increased oxidative stress modifies the cellular redox environment and, consequently, alters the endogenous clock activity and disrupts the circadianorganization of antioxidant defenses and TNF-α in the PFC. These results might highlight novel chronobiological targets for the design of therapeutic strategies for healthy aging patients.
publishDate	2024
dc.date.none.fl_str_mv	2024-07
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/266588 Ponce, Ivana Tamara; Coria Lucero, Cinthia Daiana; Lacoste, Maria Gabriela; Della Vedova, Maria Cecilia; Devia, Cristina Mabel; et al.; Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.; Dogu Kampusu Suleyman Demirel University; Journal of Cellular Neuroscience and Oxidative Stress; 16; 1; 7-2024; 1183-1194 2149-7222 CONICET Digital CONICET
url	http://hdl.handle.net/11336/266588
identifier_str_mv	Ponce, Ivana Tamara; Coria Lucero, Cinthia Daiana; Lacoste, Maria Gabriela; Della Vedova, Maria Cecilia; Devia, Cristina Mabel; et al.; Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.; Dogu Kampusu Suleyman Demirel University; Journal of Cellular Neuroscience and Oxidative Stress; 16; 1; 7-2024; 1183-1194 2149-7222 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://dergipark.org.tr/en/doi/10.37212/jcnos.1460272 info:eu-repo/semantics/altIdentifier/doi/10.37212/jcnos.1460272
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Dogu Kampusu Suleyman Demirel University
publisher.none.fl_str_mv	Dogu Kampusu Suleyman Demirel University
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repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies...

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