Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex

Autores
Carboni, Ezio; Barros, Virginia Gabriela; Ibba, Marcello; Silvagni, Alessandra; Mura, Cristina; Antonelli, Marta Cristina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is substantial evidence that prenatal exposure to adverse environmental conditions might lead to the psychiatric disorders that can appear in adolescence or in adulthood; vulnerability to drug addiction may increase as well. It is currently accepted that the alteration of catecholamine transmission in the prefrontal cortex plays a prominent role in the etiology of psychiatric disorders. We assessed basal and stimulated dopamine and noradrenaline extracellular concentration in the medial prefrontal cortex by means of microdialysis in awake male adolescent and young adult offspring of rats exposed to restraint stress in the last week of pregnancy. Catecholamine stimulation was obtained by amphetamine or nicotine. We observed that prenatal stress (PNS) did not change dopamine but decreased noradrenaline basal output in both adolescents and adults. Moreover, it decreased amphetamine stimulated dopamine output and increased amphetamine stimulated noradrenaline output. PNS decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. These data show that PNS stress modifies prefrontal cortex catecholamine transmission in a complex and age dependent manner. Our results support the view that prenatal stress may be a contributing factor for the development of psychiatric disorders and that its effect may augment drug addiction vulnerability.
Fil: Carboni, Ezio. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Barros, Virginia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Ibba, Marcello. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Silvagni, Alessandra. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Mura, Cristina. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Materia
Adolescence
Amphetamine
Dopamine
Nicotine
Noradrenaline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67580
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67580
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortexCarboni, EzioBarros, Virginia GabrielaIbba, MarcelloSilvagni, AlessandraMura, CristinaAntonelli, Marta CristinaAdolescenceAmphetamineDopamineNicotineNoradrenalinehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There is substantial evidence that prenatal exposure to adverse environmental conditions might lead to the psychiatric disorders that can appear in adolescence or in adulthood; vulnerability to drug addiction may increase as well. It is currently accepted that the alteration of catecholamine transmission in the prefrontal cortex plays a prominent role in the etiology of psychiatric disorders. We assessed basal and stimulated dopamine and noradrenaline extracellular concentration in the medial prefrontal cortex by means of microdialysis in awake male adolescent and young adult offspring of rats exposed to restraint stress in the last week of pregnancy. Catecholamine stimulation was obtained by amphetamine or nicotine. We observed that prenatal stress (PNS) did not change dopamine but decreased noradrenaline basal output in both adolescents and adults. Moreover, it decreased amphetamine stimulated dopamine output and increased amphetamine stimulated noradrenaline output. PNS decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. These data show that PNS stress modifies prefrontal cortex catecholamine transmission in a complex and age dependent manner. Our results support the view that prenatal stress may be a contributing factor for the development of psychiatric disorders and that its effect may augment drug addiction vulnerability.Fil: Carboni, Ezio. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; ItaliaFil: Barros, Virginia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Ibba, Marcello. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; ItaliaFil: Silvagni, Alessandra. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; ItaliaFil: Mura, Cristina. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; ItaliaFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaPergamon-Elsevier Science Ltd2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67580Carboni, Ezio; Barros, Virginia Gabriela; Ibba, Marcello; Silvagni, Alessandra; Mura, Cristina; et al.; Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex; Pergamon-Elsevier Science Ltd; Neuroscience; 168; 1; 6-2010; 156-1660306-4522CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2010.03.046info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306452210004392info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:35Zoai:ri.conicet.gov.ar:11336/67580instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:36.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
title Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
spellingShingle Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
Carboni, Ezio
Adolescence
Amphetamine
Dopamine
Nicotine
Noradrenaline
title_short Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
title_full Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
title_fullStr Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
title_full_unstemmed Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
title_sort Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
dc.creator.none.fl_str_mv Carboni, Ezio
Barros, Virginia Gabriela
Ibba, Marcello
Silvagni, Alessandra
Mura, Cristina
Antonelli, Marta Cristina
author Carboni, Ezio
author_facet Carboni, Ezio
Barros, Virginia Gabriela
Ibba, Marcello
Silvagni, Alessandra
Mura, Cristina
Antonelli, Marta Cristina
author_role author
author2 Barros, Virginia Gabriela
Ibba, Marcello
Silvagni, Alessandra
Mura, Cristina
Antonelli, Marta Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adolescence
Amphetamine
Dopamine
Nicotine
Noradrenaline
topic Adolescence
Amphetamine
Dopamine
Nicotine
Noradrenaline
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is substantial evidence that prenatal exposure to adverse environmental conditions might lead to the psychiatric disorders that can appear in adolescence or in adulthood; vulnerability to drug addiction may increase as well. It is currently accepted that the alteration of catecholamine transmission in the prefrontal cortex plays a prominent role in the etiology of psychiatric disorders. We assessed basal and stimulated dopamine and noradrenaline extracellular concentration in the medial prefrontal cortex by means of microdialysis in awake male adolescent and young adult offspring of rats exposed to restraint stress in the last week of pregnancy. Catecholamine stimulation was obtained by amphetamine or nicotine. We observed that prenatal stress (PNS) did not change dopamine but decreased noradrenaline basal output in both adolescents and adults. Moreover, it decreased amphetamine stimulated dopamine output and increased amphetamine stimulated noradrenaline output. PNS decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. These data show that PNS stress modifies prefrontal cortex catecholamine transmission in a complex and age dependent manner. Our results support the view that prenatal stress may be a contributing factor for the development of psychiatric disorders and that its effect may augment drug addiction vulnerability.
Fil: Carboni, Ezio. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Barros, Virginia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Ibba, Marcello. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Silvagni, Alessandra. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Mura, Cristina. Consiglio Nazionale delle Ricerche; Italia. Università di Cagliari; Italia
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
description There is substantial evidence that prenatal exposure to adverse environmental conditions might lead to the psychiatric disorders that can appear in adolescence or in adulthood; vulnerability to drug addiction may increase as well. It is currently accepted that the alteration of catecholamine transmission in the prefrontal cortex plays a prominent role in the etiology of psychiatric disorders. We assessed basal and stimulated dopamine and noradrenaline extracellular concentration in the medial prefrontal cortex by means of microdialysis in awake male adolescent and young adult offspring of rats exposed to restraint stress in the last week of pregnancy. Catecholamine stimulation was obtained by amphetamine or nicotine. We observed that prenatal stress (PNS) did not change dopamine but decreased noradrenaline basal output in both adolescents and adults. Moreover, it decreased amphetamine stimulated dopamine output and increased amphetamine stimulated noradrenaline output. PNS decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. These data show that PNS stress modifies prefrontal cortex catecholamine transmission in a complex and age dependent manner. Our results support the view that prenatal stress may be a contributing factor for the development of psychiatric disorders and that its effect may augment drug addiction vulnerability.
publishDate 2010
dc.date.none.fl_str_mv 2010-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67580
Carboni, Ezio; Barros, Virginia Gabriela; Ibba, Marcello; Silvagni, Alessandra; Mura, Cristina; et al.; Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex; Pergamon-Elsevier Science Ltd; Neuroscience; 168; 1; 6-2010; 156-166
0306-4522
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67580
identifier_str_mv Carboni, Ezio; Barros, Virginia Gabriela; Ibba, Marcello; Silvagni, Alessandra; Mura, Cristina; et al.; Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex; Pergamon-Elsevier Science Ltd; Neuroscience; 168; 1; 6-2010; 156-166
0306-4522
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2010.03.046
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306452210004392
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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