AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia
- Autores
- Basmadjian, Osvaldo Martin; Montemerlo, Antonella Evelin; Rivas, Gustavo Adolfo; Baiardi, Gustavo Carlos; Rubianes, María Dolores; Bregonzio, Claudia
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Limbic dopamine (DA) hyperactivity, a hallmark of amphetamine (AMPH) exposure, it is considered as a neurochemical feature involved in the expression of schizophrenic positive symptoms. DA neurotransmission dynamics is regulated by the uptake of extracellular transmitter at presynaptic neurons through specific transporter. Angiotensin II, through AT1 receptors (AT1-R), modulates DA neurotransmission at limbic areas. Herein, we studied AT1-R involvement after AMPH exposure on: a) development and expression of behavioral sensitization, b) in vitro striatum DA uptake. To these purposes male Wistar rats (250-300 g) were daily administered with d-AMPH (2.5 mg/kg i.p.) for 5 days. After 3 weeks of withdrawal, the behavioral sensitization was evaluated measuring locomotor activity. The AT1-R blocker, Candesartan (CV 3 mg/kg p.o.), was administered daily for 10 days, starting 5 days prior to the first AMPH injection in the prevention sensitization protocol. In the reversion protocol, either, CV or aripiprazole (antipsychotic drug widely use partial agonist of D2 receptors), were administered for 5 days starting 2 weeks after the last AMPH injection. DA uptake was measured in homogenized striatum using an electrochemical sensor, based on glassy carbon electrode modified with carbon nanotubes and polyethylenimine by amperometry. The results were analyzed by 2-way ANOVA followed by Bonferroni test or t-test. We found that behavioral sensitization was prevented and reversed by AT1-R blockade more efficiently than aripiprazole. Moreover, 5 days of CV administration increased DA uptake fact that could account for the behavioral results. We conclude that the lesser DA signaling, as a result of the increasing of its uptake, would explain the beneficial effects of AT1-R blockade in the behavioral neuroadaptations induced by AMPH.
Fil: Basmadjian, Osvaldo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Montemerlo, Antonella Evelin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Reunión Anual de Sociedades de Biociencias
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Biología
Sociedad Argentina de Protozoología
Asociación Argentina de Nanomedicinas - Materia
-
AT1 receptors
Dopamine
Amphetamine
Schizophrenia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/154017
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AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of SchizophreniaBasmadjian, Osvaldo MartinMontemerlo, Antonella EvelinRivas, Gustavo AdolfoBaiardi, Gustavo CarlosRubianes, María DoloresBregonzio, ClaudiaAT1 receptorsDopamineAmphetamineSchizophreniahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Limbic dopamine (DA) hyperactivity, a hallmark of amphetamine (AMPH) exposure, it is considered as a neurochemical feature involved in the expression of schizophrenic positive symptoms. DA neurotransmission dynamics is regulated by the uptake of extracellular transmitter at presynaptic neurons through specific transporter. Angiotensin II, through AT1 receptors (AT1-R), modulates DA neurotransmission at limbic areas. Herein, we studied AT1-R involvement after AMPH exposure on: a) development and expression of behavioral sensitization, b) in vitro striatum DA uptake. To these purposes male Wistar rats (250-300 g) were daily administered with d-AMPH (2.5 mg/kg i.p.) for 5 days. After 3 weeks of withdrawal, the behavioral sensitization was evaluated measuring locomotor activity. The AT1-R blocker, Candesartan (CV 3 mg/kg p.o.), was administered daily for 10 days, starting 5 days prior to the first AMPH injection in the prevention sensitization protocol. In the reversion protocol, either, CV or aripiprazole (antipsychotic drug widely use partial agonist of D2 receptors), were administered for 5 days starting 2 weeks after the last AMPH injection. DA uptake was measured in homogenized striatum using an electrochemical sensor, based on glassy carbon electrode modified with carbon nanotubes and polyethylenimine by amperometry. The results were analyzed by 2-way ANOVA followed by Bonferroni test or t-test. We found that behavioral sensitization was prevented and reversed by AT1-R blockade more efficiently than aripiprazole. Moreover, 5 days of CV administration increased DA uptake fact that could account for the behavioral results. We conclude that the lesser DA signaling, as a result of the increasing of its uptake, would explain the beneficial effects of AT1-R blockade in the behavioral neuroadaptations induced by AMPH.Fil: Basmadjian, Osvaldo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Montemerlo, Antonella Evelin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaReunión Anual de Sociedades de BiocienciasMar del PlataArgentinaSociedad Argentina de Investigación ClínicaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de BiologíaSociedad Argentina de ProtozoologíaAsociación Argentina de NanomedicinasFundación Revista MedicinaCostas, Monica AlejandraMarino, Gabriela InésAzurmendi, Pablo Javier2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154017AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia; Reunión Anual de Sociedades de Biociencias; Mar del Plata; Argentina; 2019; 287-2870025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/indices-de-2010-a-2019/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:45Zoai:ri.conicet.gov.ar:11336/154017instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:45.947CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
title |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
spellingShingle |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia Basmadjian, Osvaldo Martin AT1 receptors Dopamine Amphetamine Schizophrenia |
title_short |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
title_full |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
title_fullStr |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
title_full_unstemmed |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
title_sort |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia |
dc.creator.none.fl_str_mv |
Basmadjian, Osvaldo Martin Montemerlo, Antonella Evelin Rivas, Gustavo Adolfo Baiardi, Gustavo Carlos Rubianes, María Dolores Bregonzio, Claudia |
author |
Basmadjian, Osvaldo Martin |
author_facet |
Basmadjian, Osvaldo Martin Montemerlo, Antonella Evelin Rivas, Gustavo Adolfo Baiardi, Gustavo Carlos Rubianes, María Dolores Bregonzio, Claudia |
author_role |
author |
author2 |
Montemerlo, Antonella Evelin Rivas, Gustavo Adolfo Baiardi, Gustavo Carlos Rubianes, María Dolores Bregonzio, Claudia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Costas, Monica Alejandra Marino, Gabriela Inés Azurmendi, Pablo Javier |
dc.subject.none.fl_str_mv |
AT1 receptors Dopamine Amphetamine Schizophrenia |
topic |
AT1 receptors Dopamine Amphetamine Schizophrenia |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Limbic dopamine (DA) hyperactivity, a hallmark of amphetamine (AMPH) exposure, it is considered as a neurochemical feature involved in the expression of schizophrenic positive symptoms. DA neurotransmission dynamics is regulated by the uptake of extracellular transmitter at presynaptic neurons through specific transporter. Angiotensin II, through AT1 receptors (AT1-R), modulates DA neurotransmission at limbic areas. Herein, we studied AT1-R involvement after AMPH exposure on: a) development and expression of behavioral sensitization, b) in vitro striatum DA uptake. To these purposes male Wistar rats (250-300 g) were daily administered with d-AMPH (2.5 mg/kg i.p.) for 5 days. After 3 weeks of withdrawal, the behavioral sensitization was evaluated measuring locomotor activity. The AT1-R blocker, Candesartan (CV 3 mg/kg p.o.), was administered daily for 10 days, starting 5 days prior to the first AMPH injection in the prevention sensitization protocol. In the reversion protocol, either, CV or aripiprazole (antipsychotic drug widely use partial agonist of D2 receptors), were administered for 5 days starting 2 weeks after the last AMPH injection. DA uptake was measured in homogenized striatum using an electrochemical sensor, based on glassy carbon electrode modified with carbon nanotubes and polyethylenimine by amperometry. The results were analyzed by 2-way ANOVA followed by Bonferroni test or t-test. We found that behavioral sensitization was prevented and reversed by AT1-R blockade more efficiently than aripiprazole. Moreover, 5 days of CV administration increased DA uptake fact that could account for the behavioral results. We conclude that the lesser DA signaling, as a result of the increasing of its uptake, would explain the beneficial effects of AT1-R blockade in the behavioral neuroadaptations induced by AMPH. Fil: Basmadjian, Osvaldo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Montemerlo, Antonella Evelin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina Reunión Anual de Sociedades de Biociencias Mar del Plata Argentina Sociedad Argentina de Investigación Clínica Asociación Argentina de Farmacología Experimental Sociedad Argentina de Biología Sociedad Argentina de Protozoología Asociación Argentina de Nanomedicinas |
description |
Limbic dopamine (DA) hyperactivity, a hallmark of amphetamine (AMPH) exposure, it is considered as a neurochemical feature involved in the expression of schizophrenic positive symptoms. DA neurotransmission dynamics is regulated by the uptake of extracellular transmitter at presynaptic neurons through specific transporter. Angiotensin II, through AT1 receptors (AT1-R), modulates DA neurotransmission at limbic areas. Herein, we studied AT1-R involvement after AMPH exposure on: a) development and expression of behavioral sensitization, b) in vitro striatum DA uptake. To these purposes male Wistar rats (250-300 g) were daily administered with d-AMPH (2.5 mg/kg i.p.) for 5 days. After 3 weeks of withdrawal, the behavioral sensitization was evaluated measuring locomotor activity. The AT1-R blocker, Candesartan (CV 3 mg/kg p.o.), was administered daily for 10 days, starting 5 days prior to the first AMPH injection in the prevention sensitization protocol. In the reversion protocol, either, CV or aripiprazole (antipsychotic drug widely use partial agonist of D2 receptors), were administered for 5 days starting 2 weeks after the last AMPH injection. DA uptake was measured in homogenized striatum using an electrochemical sensor, based on glassy carbon electrode modified with carbon nanotubes and polyethylenimine by amperometry. The results were analyzed by 2-way ANOVA followed by Bonferroni test or t-test. We found that behavioral sensitization was prevented and reversed by AT1-R blockade more efficiently than aripiprazole. Moreover, 5 days of CV administration increased DA uptake fact that could account for the behavioral results. We conclude that the lesser DA signaling, as a result of the increasing of its uptake, would explain the beneficial effects of AT1-R blockade in the behavioral neuroadaptations induced by AMPH. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/154017 AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia; Reunión Anual de Sociedades de Biociencias; Mar del Plata; Argentina; 2019; 287-287 0025-7680 1669-9106 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/154017 |
identifier_str_mv |
AT1 receptors in striatum DA-uptake: Crucial role and relevance in an Amphetamine-sensitization model of Schizophrenia; Reunión Anual de Sociedades de Biociencias; Mar del Plata; Argentina; 2019; 287-287 0025-7680 1669-9106 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/indices-de-2010-a-2019/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Fundación Revista Medicina |
publisher.none.fl_str_mv |
Fundación Revista Medicina |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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