Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris

Autores
Espinoza Monje, Marcela; Campos, Jorge; Alvarez Villamil, Eduardo Gaspar; Jerez, Alonso; Dentice Maidana, Stefania; Elean, Mariano Daniel; Salva, Maria Susana; Kitazawa, Haruki; Villena, Julio Cesar; García Cancino, Apolinaria
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.
Fil: Espinoza Monje, Marcela. Universidad de Concepción; Chile
Fil: Campos, Jorge. Universidad de Concepción; Chile
Fil: Alvarez Villamil, Eduardo Gaspar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Jerez, Alonso. Universidad de Concepción; Chile
Fil: Dentice Maidana, Stefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
Fil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: García Cancino, Apolinaria. Universidad de Concepción; Chile
Materia
ACNE VULGARIS
CUTIBACTERIUM ACNES
IMMUNOBIOTIC
PROBIOTIC
SKIN IMMUNITY
SKIN INFLAMMATION
STAPHYLOCOCCUS AUREUS
WEISSELLA VIRIDESCENS UCO-SMC3
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/159966
Acceder
id CONICETDig_856925e215660db0919df334fa15fea3
oai_identifier_str oai:ri.conicet.gov.ar:11336/159966
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgarisEspinoza Monje, MarcelaCampos, JorgeAlvarez Villamil, Eduardo GasparJerez, AlonsoDentice Maidana, StefaniaElean, Mariano DanielSalva, Maria SusanaKitazawa, HarukiVillena, Julio CesarGarcía Cancino, ApolinariaACNE VULGARISCUTIBACTERIUM ACNESIMMUNOBIOTICPROBIOTICSKIN IMMUNITYSKIN INFLAMMATIONSTAPHYLOCOCCUS AUREUSWEISSELLA VIRIDESCENS UCO-SMC3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.Fil: Espinoza Monje, Marcela. Universidad de Concepción; ChileFil: Campos, Jorge. Universidad de Concepción; ChileFil: Alvarez Villamil, Eduardo Gaspar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Jerez, Alonso. Universidad de Concepción; ChileFil: Dentice Maidana, Stefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; ArgentinaFil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kitazawa, Haruki. Tohoku University; JapónFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: García Cancino, Apolinaria. Universidad de Concepción; ChileMDPI AG2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/159966Espinoza Monje, Marcela; Campos, Jorge; Alvarez Villamil, Eduardo Gaspar; Jerez, Alonso; Dentice Maidana, Stefania; et al.; Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris; MDPI AG; Microorganisms; 9; 7; 7-2021; 1-242076-2607CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9071486info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/7/1486info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:18:18Zoai:ri.conicet.gov.ar:11336/159966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:18:18.382CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
title Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
spellingShingle Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
Espinoza Monje, Marcela
ACNE VULGARIS
CUTIBACTERIUM ACNES
IMMUNOBIOTIC
PROBIOTIC
SKIN IMMUNITY
SKIN INFLAMMATION
STAPHYLOCOCCUS AUREUS
WEISSELLA VIRIDESCENS UCO-SMC3
title_short Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
title_full Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
title_fullStr Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
title_full_unstemmed Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
title_sort Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris
dc.creator.none.fl_str_mv Espinoza Monje, Marcela
Campos, Jorge
Alvarez Villamil, Eduardo Gaspar
Jerez, Alonso
Dentice Maidana, Stefania
Elean, Mariano Daniel
Salva, Maria Susana
Kitazawa, Haruki
Villena, Julio Cesar
García Cancino, Apolinaria
author Espinoza Monje, Marcela
author_facet Espinoza Monje, Marcela
Campos, Jorge
Alvarez Villamil, Eduardo Gaspar
Jerez, Alonso
Dentice Maidana, Stefania
Elean, Mariano Daniel
Salva, Maria Susana
Kitazawa, Haruki
Villena, Julio Cesar
García Cancino, Apolinaria
author_role author
author2 Campos, Jorge
Alvarez Villamil, Eduardo Gaspar
Jerez, Alonso
Dentice Maidana, Stefania
Elean, Mariano Daniel
Salva, Maria Susana
Kitazawa, Haruki
Villena, Julio Cesar
García Cancino, Apolinaria
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACNE VULGARIS
CUTIBACTERIUM ACNES
IMMUNOBIOTIC
PROBIOTIC
SKIN IMMUNITY
SKIN INFLAMMATION
STAPHYLOCOCCUS AUREUS
WEISSELLA VIRIDESCENS UCO-SMC3
topic ACNE VULGARIS
CUTIBACTERIUM ACNES
IMMUNOBIOTIC
PROBIOTIC
SKIN IMMUNITY
SKIN INFLAMMATION
STAPHYLOCOCCUS AUREUS
WEISSELLA VIRIDESCENS UCO-SMC3
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.
Fil: Espinoza Monje, Marcela. Universidad de Concepción; Chile
Fil: Campos, Jorge. Universidad de Concepción; Chile
Fil: Alvarez Villamil, Eduardo Gaspar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Jerez, Alonso. Universidad de Concepción; Chile
Fil: Dentice Maidana, Stefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
Fil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: García Cancino, Apolinaria. Universidad de Concepción; Chile
description Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/159966
Espinoza Monje, Marcela; Campos, Jorge; Alvarez Villamil, Eduardo Gaspar; Jerez, Alonso; Dentice Maidana, Stefania; et al.; Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris; MDPI AG; Microorganisms; 9; 7; 7-2021; 1-24
2076-2607
CONICET Digital
CONICET
url http://hdl.handle.net/11336/159966
identifier_str_mv Espinoza Monje, Marcela; Campos, Jorge; Alvarez Villamil, Eduardo Gaspar; Jerez, Alonso; Dentice Maidana, Stefania; et al.; Characterization of weissella viridescens uco-smc3 as a potential probiotic for the skin: Its beneficial role in the pathogenesis of acne vulgaris; MDPI AG; Microorganisms; 9; 7; 7-2021; 1-24
2076-2607
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9071486
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/7/1486
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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