Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse

Autores
Godoy, José Rodrigo; Funke, Maria; Ackermann, Waltraud; Haunhorst, Petra; Oesteritz, Sabrina; Capani, Francisco; Elsässer, Hans Peter; Lillig, Christopher Horst
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available. Methods: Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and --glutamyl cysteine synthetase (--GCS) in various tissues of the mouse using immunohistochemistry. Results: The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues. Conclusion: Our results imply more specific functions and interactions between the proteins of this family than previously assumed. General significance: Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases-the laboratory mouse. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
Fil: Godoy, José Rodrigo. Universitat Phillips; Alemania
Fil: Funke, Maria. Universitat Phillips; Alemania
Fil: Ackermann, Waltraud. Universitat Phillips; Alemania
Fil: Haunhorst, Petra. Universitat Phillips; Alemania
Fil: Oesteritz, Sabrina. Universitat Phillips; Alemania
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Elsässer, Hans Peter. Universitat Phillips; Alemania
Fil: Lillig, Christopher Horst. Universitat Phillips; Alemania
Materia
Glutaredoxin
Glutathione
Immunohistochemistry
Peroxiredoxin
Thioredoxin
Thioredoxin Reductase
Tissue Distribution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67575
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67575
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouseGodoy, José RodrigoFunke, MariaAckermann, WaltraudHaunhorst, PetraOesteritz, SabrinaCapani, FranciscoElsässer, Hans PeterLillig, Christopher HorstGlutaredoxinGlutathioneImmunohistochemistryPeroxiredoxinThioredoxinThioredoxin ReductaseTissue Distributionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available. Methods: Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and --glutamyl cysteine synthetase (--GCS) in various tissues of the mouse using immunohistochemistry. Results: The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues. Conclusion: Our results imply more specific functions and interactions between the proteins of this family than previously assumed. General significance: Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases-the laboratory mouse. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.Fil: Godoy, José Rodrigo. Universitat Phillips; AlemaniaFil: Funke, Maria. Universitat Phillips; AlemaniaFil: Ackermann, Waltraud. Universitat Phillips; AlemaniaFil: Haunhorst, Petra. Universitat Phillips; AlemaniaFil: Oesteritz, Sabrina. Universitat Phillips; AlemaniaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Elsässer, Hans Peter. Universitat Phillips; AlemaniaFil: Lillig, Christopher Horst. Universitat Phillips; AlemaniaElsevier Science2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67575Godoy, José Rodrigo; Funke, Maria; Ackermann, Waltraud; Haunhorst, Petra; Oesteritz, Sabrina; et al.; Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse; Elsevier Science; Biochimica et Biophysica Acta- General Subjects; 1810; 1; 1-2011; 2-920304-4165CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbagen.2010.05.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030441651000139Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:05Zoai:ri.conicet.gov.ar:11336/67575instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:05.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
title Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
spellingShingle Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
Godoy, José Rodrigo
Glutaredoxin
Glutathione
Immunohistochemistry
Peroxiredoxin
Thioredoxin
Thioredoxin Reductase
Tissue Distribution
title_short Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
title_full Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
title_fullStr Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
title_full_unstemmed Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
title_sort Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
dc.creator.none.fl_str_mv Godoy, José Rodrigo
Funke, Maria
Ackermann, Waltraud
Haunhorst, Petra
Oesteritz, Sabrina
Capani, Francisco
Elsässer, Hans Peter
Lillig, Christopher Horst
author Godoy, José Rodrigo
author_facet Godoy, José Rodrigo
Funke, Maria
Ackermann, Waltraud
Haunhorst, Petra
Oesteritz, Sabrina
Capani, Francisco
Elsässer, Hans Peter
Lillig, Christopher Horst
author_role author
author2 Funke, Maria
Ackermann, Waltraud
Haunhorst, Petra
Oesteritz, Sabrina
Capani, Francisco
Elsässer, Hans Peter
Lillig, Christopher Horst
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Glutaredoxin
Glutathione
Immunohistochemistry
Peroxiredoxin
Thioredoxin
Thioredoxin Reductase
Tissue Distribution
topic Glutaredoxin
Glutathione
Immunohistochemistry
Peroxiredoxin
Thioredoxin
Thioredoxin Reductase
Tissue Distribution
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available. Methods: Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and --glutamyl cysteine synthetase (--GCS) in various tissues of the mouse using immunohistochemistry. Results: The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues. Conclusion: Our results imply more specific functions and interactions between the proteins of this family than previously assumed. General significance: Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases-the laboratory mouse. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
Fil: Godoy, José Rodrigo. Universitat Phillips; Alemania
Fil: Funke, Maria. Universitat Phillips; Alemania
Fil: Ackermann, Waltraud. Universitat Phillips; Alemania
Fil: Haunhorst, Petra. Universitat Phillips; Alemania
Fil: Oesteritz, Sabrina. Universitat Phillips; Alemania
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Elsässer, Hans Peter. Universitat Phillips; Alemania
Fil: Lillig, Christopher Horst. Universitat Phillips; Alemania
description Background: Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease conditions, no systematic information on the presence of these proteins is available. Methods: Here, we have systematically analyzed the presence of some of the major constituents of the glutaredoxin (Grx)-, peroxiredoxin (Prx)-, and thioredoxin (Trx)-systems, i.e. Grx1, Grx2, Grx3 (TXNL-2/PICOT), Grx5, nucleoredoxin (Nrx), Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, thioredoxin reductase 1 (TrxR1), Trx2, TrxR2, and --glutamyl cysteine synthetase (--GCS) in various tissues of the mouse using immunohistochemistry. Results: The identification of the Trx family proteins in the central nervous system, sensory organs, digestive system, lymphatic system, reproductive system, urinary system, respiratory system, endocrine system, skin, heart, and muscle revealed a number of significant differences between these proteins with respect to their distribution in these tissues. Conclusion: Our results imply more specific functions and interactions between the proteins of this family than previously assumed. General significance: Crucial functions of Trx family proteins have been demonstrated in various disease conditions. A detailed overview on their distribution in various tissues will be helpful to fully comprehend their potential role and the interactions of these proteins in the most thoroughly studied model for human diseases-the laboratory mouse. This article is part of a Special Issue entitled Human and Murine Redox Protein Atlases.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67575
Godoy, José Rodrigo; Funke, Maria; Ackermann, Waltraud; Haunhorst, Petra; Oesteritz, Sabrina; et al.; Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse; Elsevier Science; Biochimica et Biophysica Acta- General Subjects; 1810; 1; 1-2011; 2-92
0304-4165
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67575
identifier_str_mv Godoy, José Rodrigo; Funke, Maria; Ackermann, Waltraud; Haunhorst, Petra; Oesteritz, Sabrina; et al.; Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse; Elsevier Science; Biochimica et Biophysica Acta- General Subjects; 1810; 1; 1-2011; 2-92
0304-4165
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbagen.2010.05.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030441651000139X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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