Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer

Autores
Fozzatti, Laura; Cheng Sheue-yann
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thyroid cancer is the most common endocrine malignancy. Although most thyroid cancer patients are successfully treated and have an excellent prognosis, a percentage of these patients will develop aggressive disease and, eventually, progress to anaplastic thyroid cancer. Since most patients with this type of aggressive thyroid carcinoma will die from the disease, new treatment strategies are urgently needed. Tumor cells live in a complex and dynamic tumor microenvironment composed of different types of stromal cells. Cancer-associated fibroblasts (CAFs) are one of the most important cell components in the tumor microenvironment of most solid tumors, including thyroid cancer. CAFs originate mainly from mesenchymal cells and resident fibroblasts that are activated and reprogrammed in response to paracrine factors and cytokines produced and released by tumor cells. Upon reprogramming, which is distinguished by the expression of different marker proteins, CAFs synthesize and secret soluble factors. The secretome of CAFs directly impacts different functions of tumor cells. This bi-directional interplay between CAFs and tumor cells within the tumor microenvironment ends up fostering tumor cancer progression. CAFs are therefore key regulators of tumor progression and represent an under-explored therapeutic target in thyroid cancer.
Fil: Fozzatti, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cheng Sheue-yann. National Institutes of Health; Estados Unidos
Materia
CANCER-ASSOCIATED FIBROBLASTS
PARACRINE COMMUNICATION
THYROID CARCINOMA
TUMOR MICROENVIRONMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130086
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancerFozzatti, LauraCheng Sheue-yannCANCER-ASSOCIATED FIBROBLASTSPARACRINE COMMUNICATIONTHYROID CARCINOMATUMOR MICROENVIRONMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Thyroid cancer is the most common endocrine malignancy. Although most thyroid cancer patients are successfully treated and have an excellent prognosis, a percentage of these patients will develop aggressive disease and, eventually, progress to anaplastic thyroid cancer. Since most patients with this type of aggressive thyroid carcinoma will die from the disease, new treatment strategies are urgently needed. Tumor cells live in a complex and dynamic tumor microenvironment composed of different types of stromal cells. Cancer-associated fibroblasts (CAFs) are one of the most important cell components in the tumor microenvironment of most solid tumors, including thyroid cancer. CAFs originate mainly from mesenchymal cells and resident fibroblasts that are activated and reprogrammed in response to paracrine factors and cytokines produced and released by tumor cells. Upon reprogramming, which is distinguished by the expression of different marker proteins, CAFs synthesize and secret soluble factors. The secretome of CAFs directly impacts different functions of tumor cells. This bi-directional interplay between CAFs and tumor cells within the tumor microenvironment ends up fostering tumor cancer progression. CAFs are therefore key regulators of tumor progression and represent an under-explored therapeutic target in thyroid cancer.Fil: Fozzatti, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Cheng Sheue-yann. National Institutes of Health; Estados UnidosKorean Endocrine Society2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130086Fozzatti, Laura; Cheng Sheue-yann; Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer; Korean Endocrine Society; Endocrinology and Metabolism; 35; 4; 11-2020; 673-6802093-596X2093-5978CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3803/EnM.2020.401info:eu-repo/semantics/altIdentifier/url/https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2020.401info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:38Zoai:ri.conicet.gov.ar:11336/130086instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:38.472CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
title Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
spellingShingle Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
Fozzatti, Laura
CANCER-ASSOCIATED FIBROBLASTS
PARACRINE COMMUNICATION
THYROID CARCINOMA
TUMOR MICROENVIRONMENT
title_short Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
title_full Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
title_fullStr Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
title_full_unstemmed Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
title_sort Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer
dc.creator.none.fl_str_mv Fozzatti, Laura
Cheng Sheue-yann
author Fozzatti, Laura
author_facet Fozzatti, Laura
Cheng Sheue-yann
author_role author
author2 Cheng Sheue-yann
author2_role author
dc.subject.none.fl_str_mv CANCER-ASSOCIATED FIBROBLASTS
PARACRINE COMMUNICATION
THYROID CARCINOMA
TUMOR MICROENVIRONMENT
topic CANCER-ASSOCIATED FIBROBLASTS
PARACRINE COMMUNICATION
THYROID CARCINOMA
TUMOR MICROENVIRONMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Thyroid cancer is the most common endocrine malignancy. Although most thyroid cancer patients are successfully treated and have an excellent prognosis, a percentage of these patients will develop aggressive disease and, eventually, progress to anaplastic thyroid cancer. Since most patients with this type of aggressive thyroid carcinoma will die from the disease, new treatment strategies are urgently needed. Tumor cells live in a complex and dynamic tumor microenvironment composed of different types of stromal cells. Cancer-associated fibroblasts (CAFs) are one of the most important cell components in the tumor microenvironment of most solid tumors, including thyroid cancer. CAFs originate mainly from mesenchymal cells and resident fibroblasts that are activated and reprogrammed in response to paracrine factors and cytokines produced and released by tumor cells. Upon reprogramming, which is distinguished by the expression of different marker proteins, CAFs synthesize and secret soluble factors. The secretome of CAFs directly impacts different functions of tumor cells. This bi-directional interplay between CAFs and tumor cells within the tumor microenvironment ends up fostering tumor cancer progression. CAFs are therefore key regulators of tumor progression and represent an under-explored therapeutic target in thyroid cancer.
Fil: Fozzatti, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cheng Sheue-yann. National Institutes of Health; Estados Unidos
description Thyroid cancer is the most common endocrine malignancy. Although most thyroid cancer patients are successfully treated and have an excellent prognosis, a percentage of these patients will develop aggressive disease and, eventually, progress to anaplastic thyroid cancer. Since most patients with this type of aggressive thyroid carcinoma will die from the disease, new treatment strategies are urgently needed. Tumor cells live in a complex and dynamic tumor microenvironment composed of different types of stromal cells. Cancer-associated fibroblasts (CAFs) are one of the most important cell components in the tumor microenvironment of most solid tumors, including thyroid cancer. CAFs originate mainly from mesenchymal cells and resident fibroblasts that are activated and reprogrammed in response to paracrine factors and cytokines produced and released by tumor cells. Upon reprogramming, which is distinguished by the expression of different marker proteins, CAFs synthesize and secret soluble factors. The secretome of CAFs directly impacts different functions of tumor cells. This bi-directional interplay between CAFs and tumor cells within the tumor microenvironment ends up fostering tumor cancer progression. CAFs are therefore key regulators of tumor progression and represent an under-explored therapeutic target in thyroid cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130086
Fozzatti, Laura; Cheng Sheue-yann; Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer; Korean Endocrine Society; Endocrinology and Metabolism; 35; 4; 11-2020; 673-680
2093-596X
2093-5978
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130086
identifier_str_mv Fozzatti, Laura; Cheng Sheue-yann; Tumor cells and cancer-associated fibroblasts: A synergistic crosstalk to promote thyroid cancer; Korean Endocrine Society; Endocrinology and Metabolism; 35; 4; 11-2020; 673-680
2093-596X
2093-5978
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3803/EnM.2020.401
info:eu-repo/semantics/altIdentifier/url/https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2020.401
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Korean Endocrine Society
publisher.none.fl_str_mv Korean Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269967595077632
score 13.13397

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