The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer

Autores
Díaz Bessone, María Inés; Gattás, Maria Jose; Laporte, Fernando Tomás; Tanaka, Max; Simian, Marina
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Estrogen receptor positive breast neoplasias represent over 70% of diagnosed breast cancers. Depending on the stage at which the tumor is detected, HER2 status and genomic risk, endocrine therapy is combined with either radio, chemo and/or targeted therapy. A growing amount of evidence supports the notion that components of the tumor microenvironment play specific roles in response to treatment and that strategies targeting these key interactions with tumor cells could pave the way to a new generation of therapies. In this review, we analyze the evidence suggesting different components of the tumor microenvironment play a role in hormone receptor positive breast cancer progression. In particular we focus on the immune system, carcinoma associated fibroblasts and the extracellular matrix. Further insight into the cross talk between these constituents of the microenvironment and the tumor cells may lead to therapies that eliminate disseminated metastatic cells early on, and thus reduce distant disease relapse which is the leading cause of death for patients who are diagnosed with this illness.
Fil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Gattás, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Laporte, Fernando Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Tanaka, Max. Vrije Universiteit Amsterdam; Países Bajos. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Simian, Marina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BREAST CANCER
CARCINOMA ASSOCIATED FIBROBLASTS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
EXTRACELLULAR MATRIX
IMMUNE SYSTEM
MICROENVIRONMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/174852
Acceder
id CONICETDig_3e7a0fe0296073147a8b4f822b9c6040
oai_identifier_str oai:ri.conicet.gov.ar:11336/174852
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast CancerDíaz Bessone, María InésGattás, Maria JoseLaporte, Fernando TomásTanaka, MaxSimian, MarinaBREAST CANCERCARCINOMA ASSOCIATED FIBROBLASTSENDOCRINE RESISTANCEESTROGEN RECEPTOREXTRACELLULAR MATRIXIMMUNE SYSTEMMICROENVIRONMENThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Estrogen receptor positive breast neoplasias represent over 70% of diagnosed breast cancers. Depending on the stage at which the tumor is detected, HER2 status and genomic risk, endocrine therapy is combined with either radio, chemo and/or targeted therapy. A growing amount of evidence supports the notion that components of the tumor microenvironment play specific roles in response to treatment and that strategies targeting these key interactions with tumor cells could pave the way to a new generation of therapies. In this review, we analyze the evidence suggesting different components of the tumor microenvironment play a role in hormone receptor positive breast cancer progression. In particular we focus on the immune system, carcinoma associated fibroblasts and the extracellular matrix. Further insight into the cross talk between these constituents of the microenvironment and the tumor cells may lead to therapies that eliminate disseminated metastatic cells early on, and thus reduce distant disease relapse which is the leading cause of death for patients who are diagnosed with this illness.Fil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Gattás, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Laporte, Fernando Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Tanaka, Max. Vrije Universiteit Amsterdam; Países Bajos. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Simian, Marina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174852Díaz Bessone, María Inés; Gattás, Maria Jose; Laporte, Fernando Tomás; Tanaka, Max; Simian, Marina; The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer; Frontiers Media; Frontiers in Endocrinology; 10; 547; 8-2019; 1-101664-2392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2019.00547info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2019.00547/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:24Zoai:ri.conicet.gov.ar:11336/174852instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:25.663CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
title The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
spellingShingle The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
Díaz Bessone, María Inés
BREAST CANCER
CARCINOMA ASSOCIATED FIBROBLASTS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
EXTRACELLULAR MATRIX
IMMUNE SYSTEM
MICROENVIRONMENT
title_short The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
title_full The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
title_fullStr The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
title_full_unstemmed The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
title_sort The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
dc.creator.none.fl_str_mv Díaz Bessone, María Inés
Gattás, Maria Jose
Laporte, Fernando Tomás
Tanaka, Max
Simian, Marina
author Díaz Bessone, María Inés
author_facet Díaz Bessone, María Inés
Gattás, Maria Jose
Laporte, Fernando Tomás
Tanaka, Max
Simian, Marina
author_role author
author2 Gattás, Maria Jose
Laporte, Fernando Tomás
Tanaka, Max
Simian, Marina
author2_role author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
CARCINOMA ASSOCIATED FIBROBLASTS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
EXTRACELLULAR MATRIX
IMMUNE SYSTEM
MICROENVIRONMENT
topic BREAST CANCER
CARCINOMA ASSOCIATED FIBROBLASTS
ENDOCRINE RESISTANCE
ESTROGEN RECEPTOR
EXTRACELLULAR MATRIX
IMMUNE SYSTEM
MICROENVIRONMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Estrogen receptor positive breast neoplasias represent over 70% of diagnosed breast cancers. Depending on the stage at which the tumor is detected, HER2 status and genomic risk, endocrine therapy is combined with either radio, chemo and/or targeted therapy. A growing amount of evidence supports the notion that components of the tumor microenvironment play specific roles in response to treatment and that strategies targeting these key interactions with tumor cells could pave the way to a new generation of therapies. In this review, we analyze the evidence suggesting different components of the tumor microenvironment play a role in hormone receptor positive breast cancer progression. In particular we focus on the immune system, carcinoma associated fibroblasts and the extracellular matrix. Further insight into the cross talk between these constituents of the microenvironment and the tumor cells may lead to therapies that eliminate disseminated metastatic cells early on, and thus reduce distant disease relapse which is the leading cause of death for patients who are diagnosed with this illness.
Fil: Díaz Bessone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Gattás, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Laporte, Fernando Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Tanaka, Max. Vrije Universiteit Amsterdam; Países Bajos. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Simian, Marina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Estrogen receptor positive breast neoplasias represent over 70% of diagnosed breast cancers. Depending on the stage at which the tumor is detected, HER2 status and genomic risk, endocrine therapy is combined with either radio, chemo and/or targeted therapy. A growing amount of evidence supports the notion that components of the tumor microenvironment play specific roles in response to treatment and that strategies targeting these key interactions with tumor cells could pave the way to a new generation of therapies. In this review, we analyze the evidence suggesting different components of the tumor microenvironment play a role in hormone receptor positive breast cancer progression. In particular we focus on the immune system, carcinoma associated fibroblasts and the extracellular matrix. Further insight into the cross talk between these constituents of the microenvironment and the tumor cells may lead to therapies that eliminate disseminated metastatic cells early on, and thus reduce distant disease relapse which is the leading cause of death for patients who are diagnosed with this illness.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174852
Díaz Bessone, María Inés; Gattás, Maria Jose; Laporte, Fernando Tomás; Tanaka, Max; Simian, Marina; The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer; Frontiers Media; Frontiers in Endocrinology; 10; 547; 8-2019; 1-10
1664-2392
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174852
identifier_str_mv Díaz Bessone, María Inés; Gattás, Maria Jose; Laporte, Fernando Tomás; Tanaka, Max; Simian, Marina; The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer; Frontiers Media; Frontiers in Endocrinology; 10; 547; 8-2019; 1-10
1664-2392
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2019.00547
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2019.00547/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269754422722560
score 13.13397

Publicaciones similares