Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth

Autores
Fabris, Victoria Teresa; Sahores, Ana; Vanzulli, Silvia; Colombo, Lucas Luis; Molinolo, Alfredo; Lanari, Claudia Lee Malvina; Lamb, Caroline Ana
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We have developed a model in which murine metastatic ductal mammary carcinomas expressing estrogen and progesterone receptors transit through different stages of hormone dependency. Hormone dependent (HD) tumors grow only in the presence of progestins, whereas hormone independent (HI) variants grow without hormone supply. We demonstrated previously that CAF from HI tumors (CAF-HI) express high levels of FGF-2 and that FGF-2 induced HD tumor growth in vivo. Our main goal was to investigate whether inoculated CAF-HI combined with purified epithelial (EPI) HD cells can induce HD tumor growth.
Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Sahores, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molinolo, Alfredo. National Institute of Health. National Institute of Craniofacial and Dental Research. Oral and Pharingeal Cancer Branch; Estados Unidos
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
MAMMARY CARCINOMAS
ACQUISITION OF HORMONE INDEPENDENCE
MICE
FISH
CARCINOMA-ASSOCIATED FIBROBLASTS
STROMA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160111
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/160111
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growthFabris, Victoria TeresaSahores, AnaVanzulli, SilviaColombo, Lucas LuisMolinolo, AlfredoLanari, Claudia Lee MalvinaLamb, Caroline AnaMAMMARY CARCINOMASACQUISITION OF HORMONE INDEPENDENCEMICEFISHCARCINOMA-ASSOCIATED FIBROBLASTSSTROMAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We have developed a model in which murine metastatic ductal mammary carcinomas expressing estrogen and progesterone receptors transit through different stages of hormone dependency. Hormone dependent (HD) tumors grow only in the presence of progestins, whereas hormone independent (HI) variants grow without hormone supply. We demonstrated previously that CAF from HI tumors (CAF-HI) express high levels of FGF-2 and that FGF-2 induced HD tumor growth in vivo. Our main goal was to investigate whether inoculated CAF-HI combined with purified epithelial (EPI) HD cells can induce HD tumor growth.Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sahores, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Molinolo, Alfredo. National Institute of Health. National Institute of Craniofacial and Dental Research. Oral and Pharingeal Cancer Branch; Estados UnidosFil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaBioMed Central2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160111Fabris, Victoria Teresa; Sahores, Ana; Vanzulli, Silvia; Colombo, Lucas Luis; Molinolo, Alfredo; et al.; Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth; BioMed Central; BMC Cancer; 10; 293; 2010; 1-101471-2407CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-293info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2407-10-293info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:03Zoai:ri.conicet.gov.ar:11336/160111instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:04.05CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
title Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
spellingShingle Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
Fabris, Victoria Teresa
MAMMARY CARCINOMAS
ACQUISITION OF HORMONE INDEPENDENCE
MICE
FISH
CARCINOMA-ASSOCIATED FIBROBLASTS
STROMA
title_short Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
title_full Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
title_fullStr Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
title_full_unstemmed Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
title_sort Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
dc.creator.none.fl_str_mv Fabris, Victoria Teresa
Sahores, Ana
Vanzulli, Silvia
Colombo, Lucas Luis
Molinolo, Alfredo
Lanari, Claudia Lee Malvina
Lamb, Caroline Ana
author Fabris, Victoria Teresa
author_facet Fabris, Victoria Teresa
Sahores, Ana
Vanzulli, Silvia
Colombo, Lucas Luis
Molinolo, Alfredo
Lanari, Claudia Lee Malvina
Lamb, Caroline Ana
author_role author
author2 Sahores, Ana
Vanzulli, Silvia
Colombo, Lucas Luis
Molinolo, Alfredo
Lanari, Claudia Lee Malvina
Lamb, Caroline Ana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MAMMARY CARCINOMAS
ACQUISITION OF HORMONE INDEPENDENCE
MICE
FISH
CARCINOMA-ASSOCIATED FIBROBLASTS
STROMA
topic MAMMARY CARCINOMAS
ACQUISITION OF HORMONE INDEPENDENCE
MICE
FISH
CARCINOMA-ASSOCIATED FIBROBLASTS
STROMA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We have developed a model in which murine metastatic ductal mammary carcinomas expressing estrogen and progesterone receptors transit through different stages of hormone dependency. Hormone dependent (HD) tumors grow only in the presence of progestins, whereas hormone independent (HI) variants grow without hormone supply. We demonstrated previously that CAF from HI tumors (CAF-HI) express high levels of FGF-2 and that FGF-2 induced HD tumor growth in vivo. Our main goal was to investigate whether inoculated CAF-HI combined with purified epithelial (EPI) HD cells can induce HD tumor growth.
Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Sahores, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molinolo, Alfredo. National Institute of Health. National Institute of Craniofacial and Dental Research. Oral and Pharingeal Cancer Branch; Estados Unidos
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We have developed a model in which murine metastatic ductal mammary carcinomas expressing estrogen and progesterone receptors transit through different stages of hormone dependency. Hormone dependent (HD) tumors grow only in the presence of progestins, whereas hormone independent (HI) variants grow without hormone supply. We demonstrated previously that CAF from HI tumors (CAF-HI) express high levels of FGF-2 and that FGF-2 induced HD tumor growth in vivo. Our main goal was to investigate whether inoculated CAF-HI combined with purified epithelial (EPI) HD cells can induce HD tumor growth.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160111
Fabris, Victoria Teresa; Sahores, Ana; Vanzulli, Silvia; Colombo, Lucas Luis; Molinolo, Alfredo; et al.; Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth; BioMed Central; BMC Cancer; 10; 293; 2010; 1-10
1471-2407
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160111
identifier_str_mv Fabris, Victoria Teresa; Sahores, Ana; Vanzulli, Silvia; Colombo, Lucas Luis; Molinolo, Alfredo; et al.; Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth; BioMed Central; BMC Cancer; 10; 293; 2010; 1-10
1471-2407
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-293
info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2407-10-293
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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