Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine

Autores
Lima, Beatriz Viviana; Coirini, Hector; Tapia, Alejandro; Feresin, Gabriela Egly
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Plants are a source of bioactive metabolites; the ability to act in multiple signalling pathways characteristic of inflammatory processes has been reported. The aim is to obtain alternative drugs with higher potency and lower undesirable effects. The species Azorella cryptantha, Oxalis erythrorhiza, Pachylaena atriplicifolia and Tetraglochin ameghinoi that grow in Andes scopes from San Juan, Argentine, are used to treat illness related to inflammatory processes in traditional medicine. The dry aerial parts were used to prepare decoctions (DC) (10% w/v), and were assayed to inhibit cyclooxygenase enzymes (COX-1 and COX-2). The effect was calculated the percent inhibition of COX isoforms measured by colorimetric assay (Kit No. 701050, Cayman Chemical), diclofenac sodium and etoricoxib were used as reference inhibitors (1-2 µg/ml). The DCs were evaluated at 18, 36 and 72 µg/ml. Regarding COX-2, DC from A. cryptantha and O. erythrorhiza were actives with inhibitory values of 82.10 and 86.97% respectively, to a concentration of the 72 µg/ml. On the other hand, all DCs were not selective to inhibit COX-2, the percentage of inhibition in COX-1 was lower. These results showed that A. cryptantha and O. erythrorhiza are consistent with the traditional use of these species in phytotherapic preparations with a potential anti-inflammatory effect, by blocking the COX-2 proinflammatory enzyme pathway.
Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicas
San Luis
Argentina
Sociedad de Biología de Cuyo
Materia
CICLOOXYGENASES
AZORELLA CRYPTANTHA
OXALIS ERYTRORHIZA
PACHYLAENA ATRIPLICIFOLIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161511
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, ArgentineLima, Beatriz VivianaCoirini, HectorTapia, AlejandroFeresin, Gabriela EglyCICLOOXYGENASESAZORELLA CRYPTANTHAOXALIS ERYTRORHIZAPACHYLAENA ATRIPLICIFOLIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Plants are a source of bioactive metabolites; the ability to act in multiple signalling pathways characteristic of inflammatory processes has been reported. The aim is to obtain alternative drugs with higher potency and lower undesirable effects. The species Azorella cryptantha, Oxalis erythrorhiza, Pachylaena atriplicifolia and Tetraglochin ameghinoi that grow in Andes scopes from San Juan, Argentine, are used to treat illness related to inflammatory processes in traditional medicine. The dry aerial parts were used to prepare decoctions (DC) (10% w/v), and were assayed to inhibit cyclooxygenase enzymes (COX-1 and COX-2). The effect was calculated the percent inhibition of COX isoforms measured by colorimetric assay (Kit No. 701050, Cayman Chemical), diclofenac sodium and etoricoxib were used as reference inhibitors (1-2 µg/ml). The DCs were evaluated at 18, 36 and 72 µg/ml. Regarding COX-2, DC from A. cryptantha and O. erythrorhiza were actives with inhibitory values of 82.10 and 86.97% respectively, to a concentration of the 72 µg/ml. On the other hand, all DCs were not selective to inhibit COX-2, the percentage of inhibition in COX-1 was lower. These results showed that A. cryptantha and O. erythrorhiza are consistent with the traditional use of these species in phytotherapic preparations with a potential anti-inflammatory effect, by blocking the COX-2 proinflammatory enzyme pathway.Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaXXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicasSan LuisArgentinaSociedad de Biología de CuyoSociedad de Biología de Cuyo2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161511Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine; XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicas; San Luis; Argentina; 2019; 50-50CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://sbcuyo.org.ar/wp-content/uploads/2019/12/Libro-BIOCELL-2019.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:36Zoai:ri.conicet.gov.ar:11336/161511instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:36.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
title Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
spellingShingle Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
Lima, Beatriz Viviana
CICLOOXYGENASES
AZORELLA CRYPTANTHA
OXALIS ERYTRORHIZA
PACHYLAENA ATRIPLICIFOLIA
title_short Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
title_full Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
title_fullStr Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
title_full_unstemmed Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
title_sort Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine
dc.creator.none.fl_str_mv Lima, Beatriz Viviana
Coirini, Hector
Tapia, Alejandro
Feresin, Gabriela Egly
author Lima, Beatriz Viviana
author_facet Lima, Beatriz Viviana
Coirini, Hector
Tapia, Alejandro
Feresin, Gabriela Egly
author_role author
author2 Coirini, Hector
Tapia, Alejandro
Feresin, Gabriela Egly
author2_role author
author
author
dc.subject.none.fl_str_mv CICLOOXYGENASES
AZORELLA CRYPTANTHA
OXALIS ERYTRORHIZA
PACHYLAENA ATRIPLICIFOLIA
topic CICLOOXYGENASES
AZORELLA CRYPTANTHA
OXALIS ERYTRORHIZA
PACHYLAENA ATRIPLICIFOLIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Plants are a source of bioactive metabolites; the ability to act in multiple signalling pathways characteristic of inflammatory processes has been reported. The aim is to obtain alternative drugs with higher potency and lower undesirable effects. The species Azorella cryptantha, Oxalis erythrorhiza, Pachylaena atriplicifolia and Tetraglochin ameghinoi that grow in Andes scopes from San Juan, Argentine, are used to treat illness related to inflammatory processes in traditional medicine. The dry aerial parts were used to prepare decoctions (DC) (10% w/v), and were assayed to inhibit cyclooxygenase enzymes (COX-1 and COX-2). The effect was calculated the percent inhibition of COX isoforms measured by colorimetric assay (Kit No. 701050, Cayman Chemical), diclofenac sodium and etoricoxib were used as reference inhibitors (1-2 µg/ml). The DCs were evaluated at 18, 36 and 72 µg/ml. Regarding COX-2, DC from A. cryptantha and O. erythrorhiza were actives with inhibitory values of 82.10 and 86.97% respectively, to a concentration of the 72 µg/ml. On the other hand, all DCs were not selective to inhibit COX-2, the percentage of inhibition in COX-1 was lower. These results showed that A. cryptantha and O. erythrorhiza are consistent with the traditional use of these species in phytotherapic preparations with a potential anti-inflammatory effect, by blocking the COX-2 proinflammatory enzyme pathway.
Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicas
San Luis
Argentina
Sociedad de Biología de Cuyo
description Plants are a source of bioactive metabolites; the ability to act in multiple signalling pathways characteristic of inflammatory processes has been reported. The aim is to obtain alternative drugs with higher potency and lower undesirable effects. The species Azorella cryptantha, Oxalis erythrorhiza, Pachylaena atriplicifolia and Tetraglochin ameghinoi that grow in Andes scopes from San Juan, Argentine, are used to treat illness related to inflammatory processes in traditional medicine. The dry aerial parts were used to prepare decoctions (DC) (10% w/v), and were assayed to inhibit cyclooxygenase enzymes (COX-1 and COX-2). The effect was calculated the percent inhibition of COX isoforms measured by colorimetric assay (Kit No. 701050, Cayman Chemical), diclofenac sodium and etoricoxib were used as reference inhibitors (1-2 µg/ml). The DCs were evaluated at 18, 36 and 72 µg/ml. Regarding COX-2, DC from A. cryptantha and O. erythrorhiza were actives with inhibitory values of 82.10 and 86.97% respectively, to a concentration of the 72 µg/ml. On the other hand, all DCs were not selective to inhibit COX-2, the percentage of inhibition in COX-1 was lower. These results showed that A. cryptantha and O. erythrorhiza are consistent with the traditional use of these species in phytotherapic preparations with a potential anti-inflammatory effect, by blocking the COX-2 proinflammatory enzyme pathway.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161511
Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine; XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicas; San Luis; Argentina; 2019; 50-50
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161511
identifier_str_mv Cox 1 and cox 2 inhibitions by a decoction of andean species from San Juan province, Argentine; XXXVII Reunión Científica Anual de la Sociedad de Biología de Cuyo: Educación, salud y ambiente: Los nuevos desafíos en las ciencias biológicas; San Luis; Argentina; 2019; 50-50
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://sbcuyo.org.ar/wp-content/uploads/2019/12/Libro-BIOCELL-2019.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad de Biología de Cuyo
publisher.none.fl_str_mv Sociedad de Biología de Cuyo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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