Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs

Autores
Lima, Beatriz Viviana; Sortino, Maximiliano Andrés; Tapia, Alejandro; Feresin, Gabriela Egly
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fl uconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafi ne showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum(FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting fi ndings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum.
Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Materia
ANTIFUNGAL
ESSENTIAL OIL
SYNERGISM;
AZORELLA CRYPTANTHA
CANDIDA ALBICANS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/223819
Acceder
id CONICETDig_350e659d59192102431858b92d75460b
oai_identifier_str oai:ri.conicet.gov.ar:11336/223819
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugsLima, Beatriz VivianaSortino, Maximiliano AndrésTapia, AlejandroFeresin, Gabriela EglyANTIFUNGALESSENTIAL OILSYNERGISM;AZORELLA CRYPTANTHACANDIDA ALBICANShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fl uconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafi ne showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum(FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting fi ndings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum.Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaPeertechz Publications2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/223819Lima, Beatriz Viviana; Sortino, Maximiliano Andrés; Tapia, Alejandro; Feresin, Gabriela Egly; Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs; Peertechz Publications; International Journal of Pharmaceutical Sciences and Developmental Research; 8; 1; 8-2022; 23-312640-7760CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.peertechzpublications.com/articles/IJPSDR-8-139.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.17352/ijpsdr.000039info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:24Zoai:ri.conicet.gov.ar:11336/223819instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:24.491CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
title Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
spellingShingle Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
Lima, Beatriz Viviana
ANTIFUNGAL
ESSENTIAL OIL
SYNERGISM;
AZORELLA CRYPTANTHA
CANDIDA ALBICANS
title_short Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
title_full Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
title_fullStr Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
title_full_unstemmed Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
title_sort Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs
dc.creator.none.fl_str_mv Lima, Beatriz Viviana
Sortino, Maximiliano Andrés
Tapia, Alejandro
Feresin, Gabriela Egly
author Lima, Beatriz Viviana
author_facet Lima, Beatriz Viviana
Sortino, Maximiliano Andrés
Tapia, Alejandro
Feresin, Gabriela Egly
author_role author
author2 Sortino, Maximiliano Andrés
Tapia, Alejandro
Feresin, Gabriela Egly
author2_role author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL
ESSENTIAL OIL
SYNERGISM;
AZORELLA CRYPTANTHA
CANDIDA ALBICANS
topic ANTIFUNGAL
ESSENTIAL OIL
SYNERGISM;
AZORELLA CRYPTANTHA
CANDIDA ALBICANS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fl uconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafi ne showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum(FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting fi ndings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum.
Fil: Lima, Beatriz Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
description The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fl uconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafi ne showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum(FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting fi ndings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/223819
Lima, Beatriz Viviana; Sortino, Maximiliano Andrés; Tapia, Alejandro; Feresin, Gabriela Egly; Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs; Peertechz Publications; International Journal of Pharmaceutical Sciences and Developmental Research; 8; 1; 8-2022; 23-31
2640-7760
CONICET Digital
CONICET
url http://hdl.handle.net/11336/223819
identifier_str_mv Lima, Beatriz Viviana; Sortino, Maximiliano Andrés; Tapia, Alejandro; Feresin, Gabriela Egly; Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs; Peertechz Publications; International Journal of Pharmaceutical Sciences and Developmental Research; 8; 1; 8-2022; 23-31
2640-7760
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.peertechzpublications.com/articles/IJPSDR-8-139.pdf
info:eu-repo/semantics/altIdentifier/doi/10.17352/ijpsdr.000039
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Peertechz Publications
publisher.none.fl_str_mv Peertechz Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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