In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
- Autores
- Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; Bombicino, Karina; Radice, Marcela Alejandra; Gutkind, Gabriel Osvaldo; Vay, Carlos; Famiglietti, Ángela
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.
Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina - Materia
-
Acinetobacter baumannii
Antimicrobials activity
Antimicrobial resistance
Time-kill assay
Colistin-Heteroresistance
Rifampicin
Imipenem - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/16481
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In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clonesRodríguez, Carlos HernánDe Ambrosio, AlejandraBajuk, MilenaSpinozzi, MarielaNastro, MarcelaBombicino, KarinaRadice, Marcela AlejandraGutkind, Gabriel OsvaldoVay, CarlosFamiglietti, ÁngelaAcinetobacter baumanniiAntimicrobials activityAntimicrobial resistanceTime-kill assayColistin-HeteroresistanceRifampicinImipenemhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaOpen Learning on Enteric Pathogens2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16481Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-1672036-65901972-2680enginfo:eu-repo/semantics/altIdentifier/url/https://jidc.org/index.php/journal/article/view/20351457info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.604info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:11Zoai:ri.conicet.gov.ar:11336/16481instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:11.827CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
title |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
spellingShingle |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones Rodríguez, Carlos Hernán Acinetobacter baumannii Antimicrobials activity Antimicrobial resistance Time-kill assay Colistin-Heteroresistance Rifampicin Imipenem |
title_short |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
title_full |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
title_fullStr |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
title_full_unstemmed |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
title_sort |
In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones |
dc.creator.none.fl_str_mv |
Rodríguez, Carlos Hernán De Ambrosio, Alejandra Bajuk, Milena Spinozzi, Mariela Nastro, Marcela Bombicino, Karina Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Vay, Carlos Famiglietti, Ángela |
author |
Rodríguez, Carlos Hernán |
author_facet |
Rodríguez, Carlos Hernán De Ambrosio, Alejandra Bajuk, Milena Spinozzi, Mariela Nastro, Marcela Bombicino, Karina Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Vay, Carlos Famiglietti, Ángela |
author_role |
author |
author2 |
De Ambrosio, Alejandra Bajuk, Milena Spinozzi, Mariela Nastro, Marcela Bombicino, Karina Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Vay, Carlos Famiglietti, Ángela |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Acinetobacter baumannii Antimicrobials activity Antimicrobial resistance Time-kill assay Colistin-Heteroresistance Rifampicin Imipenem |
topic |
Acinetobacter baumannii Antimicrobials activity Antimicrobial resistance Time-kill assay Colistin-Heteroresistance Rifampicin Imipenem |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced. Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina |
description |
BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/16481 Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-167 2036-6590 1972-2680 |
url |
http://hdl.handle.net/11336/16481 |
identifier_str_mv |
Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-167 2036-6590 1972-2680 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://jidc.org/index.php/journal/article/view/20351457 info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.604 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Open Learning on Enteric Pathogens |
publisher.none.fl_str_mv |
Open Learning on Enteric Pathogens |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |