In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones

Autores
Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; Bombicino, Karina; Radice, Marcela Alejandra; Gutkind, Gabriel Osvaldo; Vay, Carlos; Famiglietti, Ángela
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.
Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Acinetobacter baumannii
Antimicrobials activity
Antimicrobial resistance
Time-kill assay
Colistin-Heteroresistance
Rifampicin
Imipenem
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16481

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clonesRodríguez, Carlos HernánDe Ambrosio, AlejandraBajuk, MilenaSpinozzi, MarielaNastro, MarcelaBombicino, KarinaRadice, Marcela AlejandraGutkind, Gabriel OsvaldoVay, CarlosFamiglietti, ÁngelaAcinetobacter baumanniiAntimicrobials activityAntimicrobial resistanceTime-kill assayColistin-HeteroresistanceRifampicinImipenemhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaOpen Learning on Enteric Pathogens2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16481Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-1672036-65901972-2680enginfo:eu-repo/semantics/altIdentifier/url/https://jidc.org/index.php/journal/article/view/20351457info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.604info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:11Zoai:ri.conicet.gov.ar:11336/16481instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:11.827CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
title In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
spellingShingle In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
Rodríguez, Carlos Hernán
Acinetobacter baumannii
Antimicrobials activity
Antimicrobial resistance
Time-kill assay
Colistin-Heteroresistance
Rifampicin
Imipenem
title_short In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
title_full In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
title_fullStr In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
title_full_unstemmed In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
title_sort In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones
dc.creator.none.fl_str_mv Rodríguez, Carlos Hernán
De Ambrosio, Alejandra
Bajuk, Milena
Spinozzi, Mariela
Nastro, Marcela
Bombicino, Karina
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Vay, Carlos
Famiglietti, Ángela
author Rodríguez, Carlos Hernán
author_facet Rodríguez, Carlos Hernán
De Ambrosio, Alejandra
Bajuk, Milena
Spinozzi, Mariela
Nastro, Marcela
Bombicino, Karina
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Vay, Carlos
Famiglietti, Ángela
author_role author
author2 De Ambrosio, Alejandra
Bajuk, Milena
Spinozzi, Mariela
Nastro, Marcela
Bombicino, Karina
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Vay, Carlos
Famiglietti, Ángela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acinetobacter baumannii
Antimicrobials activity
Antimicrobial resistance
Time-kill assay
Colistin-Heteroresistance
Rifampicin
Imipenem
topic Acinetobacter baumannii
Antimicrobials activity
Antimicrobial resistance
Time-kill assay
Colistin-Heteroresistance
Rifampicin
Imipenem
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.
Fil: Rodríguez, Carlos Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: De Ambrosio, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bajuk, Milena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Spinozzi, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Bombicino, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Famiglietti, Ángela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description BACKGROUND: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance. METHODOLOGY: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin. RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent. CONCLUSION: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16481
Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-167
2036-6590
1972-2680
url http://hdl.handle.net/11336/16481
identifier_str_mv Rodríguez, Carlos Hernán; De Ambrosio, Alejandra; Bajuk, Milena; Spinozzi, Mariela; Nastro, Marcela; et al.; In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones; Open Learning on Enteric Pathogens; Journal of Infection in Developing Countries; 4; 3; 3-2010; 164-167
2036-6590
1972-2680
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.604
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Open Learning on Enteric Pathogens
publisher.none.fl_str_mv Open Learning on Enteric Pathogens
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
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