Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload
- Autores
- Sánchez Campos, Sofía; Salvador, Gabriela Alejandra
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors for pathological α-syn aggregation. In this work, we characterized the phospholipid remodeling pathways that regulate FA availability in dopaminergic neurons overexpressing α-syn variants (WT and A53T) and exposed to iron-overload. Increased cellular oxidant and lipid peroxidation levels were observed in dopaminergic neurons exposed to iron-overload. The inhibition of calcium-independent phospholipase A2 (deacylation pathway) provoked an increase in the extent of cellular damage induced by iron-overload. In this connection, phospholipid acylation was differentially affected by iron overload and the presence of α- syn variants. FA incorporation into phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was increased in dopaminergic neurons harboring WT α-syn. This acylation profile was not altered by iron-overload. Neurons expressing A53T α-syn (a variant present in autosomic dominant PD and with high iron affinity) showed a diminished FA esterification in PC and PE. This effect was enhanced in iron overloaded neurons. Our results show that FA availability is differentially regulated by α-syn variants and iron overload in this in vitro model of PD
Fil: Sánchez Campos, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expression
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular - Materia
-
NEURODEGENERATION
OXIDATIVE STRESS
IRON
ACYLTRANSFERASE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/246944
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Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overloadSánchez Campos, SofíaSalvador, Gabriela AlejandraNEURODEGENERATIONOXIDATIVE STRESSIRONACYLTRANSFERASEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors for pathological α-syn aggregation. In this work, we characterized the phospholipid remodeling pathways that regulate FA availability in dopaminergic neurons overexpressing α-syn variants (WT and A53T) and exposed to iron-overload. Increased cellular oxidant and lipid peroxidation levels were observed in dopaminergic neurons exposed to iron-overload. The inhibition of calcium-independent phospholipase A2 (deacylation pathway) provoked an increase in the extent of cellular damage induced by iron-overload. In this connection, phospholipid acylation was differentially affected by iron overload and the presence of α- syn variants. FA incorporation into phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was increased in dopaminergic neurons harboring WT α-syn. This acylation profile was not altered by iron-overload. Neurons expressing A53T α-syn (a variant present in autosomic dominant PD and with high iron affinity) showed a diminished FA esterification in PC and PE. This effect was enhanced in iron overloaded neurons. Our results show that FA availability is differentially regulated by α-syn variants and iron overload in this in vitro model of PDFil: Sánchez Campos, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaSociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expressionBuenos AiresArgentinaSociedad Argentina de Investigación en Bioquímica y Biología MolecularInstituto de Histología y Embriología “Dr. Mario H. Burgos”2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246944Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload; Sociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expression; Buenos Aires; Argentina; 2013; 40-400327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.saib.org.ar/sites/default/files/BIOCELL-SAIB-2013.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:00:31Zoai:ri.conicet.gov.ar:11336/246944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:00:32.043CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
title |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
spellingShingle |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload Sánchez Campos, Sofía NEURODEGENERATION OXIDATIVE STRESS IRON ACYLTRANSFERASE |
title_short |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
title_full |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
title_fullStr |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
title_full_unstemmed |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
title_sort |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload |
dc.creator.none.fl_str_mv |
Sánchez Campos, Sofía Salvador, Gabriela Alejandra |
author |
Sánchez Campos, Sofía |
author_facet |
Sánchez Campos, Sofía Salvador, Gabriela Alejandra |
author_role |
author |
author2 |
Salvador, Gabriela Alejandra |
author2_role |
author |
dc.subject.none.fl_str_mv |
NEURODEGENERATION OXIDATIVE STRESS IRON ACYLTRANSFERASE |
topic |
NEURODEGENERATION OXIDATIVE STRESS IRON ACYLTRANSFERASE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors for pathological α-syn aggregation. In this work, we characterized the phospholipid remodeling pathways that regulate FA availability in dopaminergic neurons overexpressing α-syn variants (WT and A53T) and exposed to iron-overload. Increased cellular oxidant and lipid peroxidation levels were observed in dopaminergic neurons exposed to iron-overload. The inhibition of calcium-independent phospholipase A2 (deacylation pathway) provoked an increase in the extent of cellular damage induced by iron-overload. In this connection, phospholipid acylation was differentially affected by iron overload and the presence of α- syn variants. FA incorporation into phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was increased in dopaminergic neurons harboring WT α-syn. This acylation profile was not altered by iron-overload. Neurons expressing A53T α-syn (a variant present in autosomic dominant PD and with high iron affinity) showed a diminished FA esterification in PC and PE. This effect was enhanced in iron overloaded neurons. Our results show that FA availability is differentially regulated by α-syn variants and iron overload in this in vitro model of PD Fil: Sánchez Campos, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Sociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expression Buenos Aires Argentina Sociedad Argentina de Investigación en Bioquímica y Biología Molecular |
description |
Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors for pathological α-syn aggregation. In this work, we characterized the phospholipid remodeling pathways that regulate FA availability in dopaminergic neurons overexpressing α-syn variants (WT and A53T) and exposed to iron-overload. Increased cellular oxidant and lipid peroxidation levels were observed in dopaminergic neurons exposed to iron-overload. The inhibition of calcium-independent phospholipase A2 (deacylation pathway) provoked an increase in the extent of cellular damage induced by iron-overload. In this connection, phospholipid acylation was differentially affected by iron overload and the presence of α- syn variants. FA incorporation into phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was increased in dopaminergic neurons harboring WT α-syn. This acylation profile was not altered by iron-overload. Neurons expressing A53T α-syn (a variant present in autosomic dominant PD and with high iron affinity) showed a diminished FA esterification in PC and PE. This effect was enhanced in iron overloaded neurons. Our results show that FA availability is differentially regulated by α-syn variants and iron overload in this in vitro model of PD |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/246944 Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload; Sociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expression; Buenos Aires; Argentina; 2013; 40-40 0327-9545 1667-5746 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/246944 |
identifier_str_mv |
Phospholipid remodeling in dopaminergic neurons: role of α-synuclein variants and iron overload; Sociedad Argentina de Investigación en Bioquímica y Biología Molecular. Molecular mechanisms in cell signaling and gene expression; Buenos Aires; Argentina; 2013; 40-40 0327-9545 1667-5746 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.saib.org.ar/sites/default/files/BIOCELL-SAIB-2013.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Nacional |
dc.publisher.none.fl_str_mv |
Instituto de Histología y Embriología “Dr. Mario H. Burgos” |
publisher.none.fl_str_mv |
Instituto de Histología y Embriología “Dr. Mario H. Burgos” |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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12.8982525 |