Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila

• Autores: Huetteroth, Wolf; Perisse, Emmanuel; Lin, Suewei; Klappenbach, Martín; Burke, Christopher; Waddell, Scott
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Dopamine; Reward; Drosophila
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.
Fil: Huetteroth, Wolf. University of Oxford; Reino Unido. University of Konstanz; Alemania
Fil: Perisse, Emmanuel. University of Oxford; Reino Unido
Fil: Lin, Suewei. University of Oxford; Reino Unido
Fil: Klappenbach, Martín. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Burke, Christopher. University of Oxford; Reino Unido
Fil: Waddell, Scott. University of Oxford; Reino Unido