Molecular control of animal cell cytokinesis

Autores
Fededa, Juan Pablo; Gerlich, Daniel W.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
Fil: Fededa, Juan Pablo. Swiss Federal Institute Of Technology Zurich; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerlich, Daniel W.. Swiss Federal Institute Of Technology Zurich; Suiza
Materia
Cytokinesis
Anaphase Spindle Reorganization
Actomyosin Ring Assembly
Abscission
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20338
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/20338
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Molecular control of animal cell cytokinesisFededa, Juan PabloGerlich, Daniel W.CytokinesisAnaphase Spindle ReorganizationActomyosin Ring AssemblyAbscissionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.Fil: Fededa, Juan Pablo. Swiss Federal Institute Of Technology Zurich; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gerlich, Daniel W.. Swiss Federal Institute Of Technology Zurich; SuizaNature Publishing Group2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20338Fededa, Juan Pablo; Gerlich, Daniel W.; Molecular control of animal cell cytokinesis; Nature Publishing Group; Nature Cell Biology; 14; 5; 5-2012; 440-4471465-73921476-4679CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/ncb2482info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/ncb/journal/v14/n5/full/ncb2482.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:05Zoai:ri.conicet.gov.ar:11336/20338instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:06.219CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular control of animal cell cytokinesis
title Molecular control of animal cell cytokinesis
spellingShingle Molecular control of animal cell cytokinesis
Fededa, Juan Pablo
Cytokinesis
Anaphase Spindle Reorganization
Actomyosin Ring Assembly
Abscission
title_short Molecular control of animal cell cytokinesis
title_full Molecular control of animal cell cytokinesis
title_fullStr Molecular control of animal cell cytokinesis
title_full_unstemmed Molecular control of animal cell cytokinesis
title_sort Molecular control of animal cell cytokinesis
dc.creator.none.fl_str_mv Fededa, Juan Pablo
Gerlich, Daniel W.
author Fededa, Juan Pablo
author_facet Fededa, Juan Pablo
Gerlich, Daniel W.
author_role author
author2 Gerlich, Daniel W.
author2_role author
dc.subject.none.fl_str_mv Cytokinesis
Anaphase Spindle Reorganization
Actomyosin Ring Assembly
Abscission
topic Cytokinesis
Anaphase Spindle Reorganization
Actomyosin Ring Assembly
Abscission
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
Fil: Fededa, Juan Pablo. Swiss Federal Institute Of Technology Zurich; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerlich, Daniel W.. Swiss Federal Institute Of Technology Zurich; Suiza
description Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20338
Fededa, Juan Pablo; Gerlich, Daniel W.; Molecular control of animal cell cytokinesis; Nature Publishing Group; Nature Cell Biology; 14; 5; 5-2012; 440-447
1465-7392
1476-4679
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20338
identifier_str_mv Fededa, Juan Pablo; Gerlich, Daniel W.; Molecular control of animal cell cytokinesis; Nature Publishing Group; Nature Cell Biology; 14; 5; 5-2012; 440-447
1465-7392
1476-4679
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/ncb2482
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/ncb/journal/v14/n5/full/ncb2482.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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