Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties

Autores
Caracciolo, Pablo Christian; de Queiroz, A. A. A.; Higa, O. Z.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(ε-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: de Queiroz, A. A. A.. Universidade Federal de Itajubá; Brasil
Fil: Higa, O. Z.. Universidade Federal de Itajubá; Brasil
Fil: Buffa, Fabián Alejandro. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Blood Compatibility
Chain Extender
Cytotoxicity
Segmented Poly(Esterurethane Urea)S
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67983
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67983
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological propertiesCaracciolo, Pablo Christiande Queiroz, A. A. A.Higa, O. Z.Buffa, Fabián AlejandroAbraham, Gustavo AbelBlood CompatibilityChain ExtenderCytotoxicitySegmented Poly(Esterurethane Urea)Shttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(ε-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: de Queiroz, A. A. A.. Universidade Federal de Itajubá; BrasilFil: Higa, O. Z.. Universidade Federal de Itajubá; BrasilFil: Buffa, Fabián Alejandro. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67983Caracciolo, Pablo Christian; de Queiroz, A. A. A.; Higa, O. Z.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel; Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties; Elsevier; Acta Biomaterialia; 4; 4; 7-2008; 976-9881742-7061CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1742706108000494info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2008.02.016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:08:18Zoai:ri.conicet.gov.ar:11336/67983instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:08:18.353CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
title Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
spellingShingle Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
Caracciolo, Pablo Christian
Blood Compatibility
Chain Extender
Cytotoxicity
Segmented Poly(Esterurethane Urea)S
title_short Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
title_full Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
title_fullStr Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
title_full_unstemmed Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
title_sort Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
dc.creator.none.fl_str_mv Caracciolo, Pablo Christian
de Queiroz, A. A. A.
Higa, O. Z.
Buffa, Fabián Alejandro
Abraham, Gustavo Abel
author Caracciolo, Pablo Christian
author_facet Caracciolo, Pablo Christian
de Queiroz, A. A. A.
Higa, O. Z.
Buffa, Fabián Alejandro
Abraham, Gustavo Abel
author_role author
author2 de Queiroz, A. A. A.
Higa, O. Z.
Buffa, Fabián Alejandro
Abraham, Gustavo Abel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Blood Compatibility
Chain Extender
Cytotoxicity
Segmented Poly(Esterurethane Urea)S
topic Blood Compatibility
Chain Extender
Cytotoxicity
Segmented Poly(Esterurethane Urea)S
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(ε-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: de Queiroz, A. A. A.. Universidade Federal de Itajubá; Brasil
Fil: Higa, O. Z.. Universidade Federal de Itajubá; Brasil
Fil: Buffa, Fabián Alejandro. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(ε-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67983
Caracciolo, Pablo Christian; de Queiroz, A. A. A.; Higa, O. Z.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel; Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties; Elsevier; Acta Biomaterialia; 4; 4; 7-2008; 976-988
1742-7061
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67983
identifier_str_mv Caracciolo, Pablo Christian; de Queiroz, A. A. A.; Higa, O. Z.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel; Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties; Elsevier; Acta Biomaterialia; 4; 4; 7-2008; 976-988
1742-7061
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1742706108000494
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2008.02.016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782453186822144
score 12.982451

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