Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films

Autores
Adhikari, Kiran R.; Stanishevskaya, Inessa; Caracciolo, Pablo Christian; Abraham, Gustavo Abel; Thomas, Vinoy
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, we report the electrospinning and mechano-morphological characterizations of scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 ± 0.5 MPa), and maximum elongation (150% ± 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.
Fil: Adhikari, Kiran R.. University of Alabama at Birmingahm; Estados Unidos
Fil: Stanishevskaya, Inessa. Rensselaer Polytechnic Institute; Estados Unidos
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Thomas, Vinoy. University of Alabama at Birmingahm; Estados Unidos
Materia
ELECTROSPINNING
NANOSTRUCTURE
POLYURETHANE UREA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182982
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/182982
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and filmsAdhikari, Kiran R.Stanishevskaya, InessaCaracciolo, Pablo ChristianAbraham, Gustavo AbelThomas, VinoyELECTROSPINNINGNANOSTRUCTUREPOLYURETHANE UREAhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2In this work, we report the electrospinning and mechano-morphological characterizations of scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 ± 0.5 MPa), and maximum elongation (150% ± 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.Fil: Adhikari, Kiran R.. University of Alabama at Birmingahm; Estados UnidosFil: Stanishevskaya, Inessa. Rensselaer Polytechnic Institute; Estados UnidosFil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Thomas, Vinoy. University of Alabama at Birmingahm; Estados UnidosMolecular Diversity Preservation International2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182982Adhikari, Kiran R.; Stanishevskaya, Inessa; Caracciolo, Pablo Christian; Abraham, Gustavo Abel; Thomas, Vinoy; Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films; Molecular Diversity Preservation International; Molecules; 26; 13; 7-2021; 1-141420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/13/3847info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26133847info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:41Zoai:ri.conicet.gov.ar:11336/182982instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:41.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
title Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
spellingShingle Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
Adhikari, Kiran R.
ELECTROSPINNING
NANOSTRUCTURE
POLYURETHANE UREA
title_short Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
title_full Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
title_fullStr Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
title_full_unstemmed Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
title_sort Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films
dc.creator.none.fl_str_mv Adhikari, Kiran R.
Stanishevskaya, Inessa
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Thomas, Vinoy
author Adhikari, Kiran R.
author_facet Adhikari, Kiran R.
Stanishevskaya, Inessa
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Thomas, Vinoy
author_role author
author2 Stanishevskaya, Inessa
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Thomas, Vinoy
author2_role author
author
author
author
dc.subject.none.fl_str_mv ELECTROSPINNING
NANOSTRUCTURE
POLYURETHANE UREA
topic ELECTROSPINNING
NANOSTRUCTURE
POLYURETHANE UREA
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work, we report the electrospinning and mechano-morphological characterizations of scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 ± 0.5 MPa), and maximum elongation (150% ± 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.
Fil: Adhikari, Kiran R.. University of Alabama at Birmingahm; Estados Unidos
Fil: Stanishevskaya, Inessa. Rensselaer Polytechnic Institute; Estados Unidos
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Thomas, Vinoy. University of Alabama at Birmingahm; Estados Unidos
description In this work, we report the electrospinning and mechano-morphological characterizations of scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 ± 0.5 MPa), and maximum elongation (150% ± 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182982
Adhikari, Kiran R.; Stanishevskaya, Inessa; Caracciolo, Pablo Christian; Abraham, Gustavo Abel; Thomas, Vinoy; Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films; Molecular Diversity Preservation International; Molecules; 26; 13; 7-2021; 1-14
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182982
identifier_str_mv Adhikari, Kiran R.; Stanishevskaya, Inessa; Caracciolo, Pablo Christian; Abraham, Gustavo Abel; Thomas, Vinoy; Novel poly(Ester urethane urea)/polydioxanone blends: Electrospun fibrous meshes and films; Molecular Diversity Preservation International; Molecules; 26; 13; 7-2021; 1-14
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/13/3847
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26133847
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613287675691008
score 13.070432

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