Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
- Autores
- Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.
Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Lacey, Eileen Anne. University of California at Berkeley; Estados Unidos - Materia
-
IMMUNOCOMPETENCE
MATE CHOICE
MHC
PARASITE LOAD - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/105884
Ver los metadatos del registro completo
id |
CONICETDig_8231f7f1fc0ce27d55b35411666f0af0 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/105884 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarumCutrera, Ana PaulaZenuto, Roxana RitaLacey, Eileen AnneIMMUNOCOMPETENCEMATE CHOICEMHCPARASITE LOADhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Lacey, Eileen Anne. University of California at Berkeley; Estados UnidosAlliance Communications Group Division Allen Press2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105884Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-6950022-2372CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1644/13-MAMM-A-120info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jmammal/article/95/4/679/881818info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:48Zoai:ri.conicet.gov.ar:11336/105884instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:48.432CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
title |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
spellingShingle |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum Cutrera, Ana Paula IMMUNOCOMPETENCE MATE CHOICE MHC PARASITE LOAD |
title_short |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
title_full |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
title_fullStr |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
title_full_unstemmed |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
title_sort |
Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum |
dc.creator.none.fl_str_mv |
Cutrera, Ana Paula Zenuto, Roxana Rita Lacey, Eileen Anne |
author |
Cutrera, Ana Paula |
author_facet |
Cutrera, Ana Paula Zenuto, Roxana Rita Lacey, Eileen Anne |
author_role |
author |
author2 |
Zenuto, Roxana Rita Lacey, Eileen Anne |
author2_role |
author author |
dc.subject.none.fl_str_mv |
IMMUNOCOMPETENCE MATE CHOICE MHC PARASITE LOAD |
topic |
IMMUNOCOMPETENCE MATE CHOICE MHC PARASITE LOAD |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system. Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina Fil: Lacey, Eileen Anne. University of California at Berkeley; Estados Unidos |
description |
We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/105884 Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-695 0022-2372 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/105884 |
identifier_str_mv |
Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-695 0022-2372 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1644/13-MAMM-A-120 info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jmammal/article/95/4/679/881818 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Alliance Communications Group Division Allen Press |
publisher.none.fl_str_mv |
Alliance Communications Group Division Allen Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613877208186880 |
score |
13.070432 |