Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum

Autores
Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.
Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Lacey, Eileen Anne. University of California at Berkeley; Estados Unidos
Materia
IMMUNOCOMPETENCE
MATE CHOICE
MHC
PARASITE LOAD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105884

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network_name_str CONICET Digital (CONICET)
spelling Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarumCutrera, Ana PaulaZenuto, Roxana RitaLacey, Eileen AnneIMMUNOCOMPETENCEMATE CHOICEMHCPARASITE LOADhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Lacey, Eileen Anne. University of California at Berkeley; Estados UnidosAlliance Communications Group Division Allen Press2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105884Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-6950022-2372CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1644/13-MAMM-A-120info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jmammal/article/95/4/679/881818info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:48Zoai:ri.conicet.gov.ar:11336/105884instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:48.432CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
title Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
spellingShingle Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
Cutrera, Ana Paula
IMMUNOCOMPETENCE
MATE CHOICE
MHC
PARASITE LOAD
title_short Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
title_full Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
title_fullStr Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
title_full_unstemmed Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
title_sort Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum
dc.creator.none.fl_str_mv Cutrera, Ana Paula
Zenuto, Roxana Rita
Lacey, Eileen Anne
author Cutrera, Ana Paula
author_facet Cutrera, Ana Paula
Zenuto, Roxana Rita
Lacey, Eileen Anne
author_role author
author2 Zenuto, Roxana Rita
Lacey, Eileen Anne
author2_role author
author
dc.subject.none.fl_str_mv IMMUNOCOMPETENCE
MATE CHOICE
MHC
PARASITE LOAD
topic IMMUNOCOMPETENCE
MATE CHOICE
MHC
PARASITE LOAD
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.
Fil: Cutrera, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Zenuto, Roxana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Lacey, Eileen Anne. University of California at Berkeley; Estados Unidos
description We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses. As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105884
Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-695
0022-2372
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105884
identifier_str_mv Cutrera, Ana Paula; Zenuto, Roxana Rita; Lacey, Eileen Anne; Interpopulation differences in parasite load and variable selective pressures on MHC genes in Ctenomys talarum; Alliance Communications Group Division Allen Press; Journal of Mammalogy; 95; 4; 8-2014; 679-695
0022-2372
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1644/13-MAMM-A-120
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jmammal/article/95/4/679/881818
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Alliance Communications Group Division Allen Press
publisher.none.fl_str_mv Alliance Communications Group Division Allen Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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