Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?

Autores
Ojeda, Diego Sebastian; Till, Andreas; Quarleri, Jorge Fabian
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associated with neuroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled (Rawat et al., 2019).
Fil: Ojeda, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina
Fil: Till, Andreas. Universitat Bonn; Alemania
Fil: Quarleri, Jorge Fabian. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
HIV
ASTROCITOS
INFLAMASOMA
PIROPTOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112181
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?Ojeda, Diego SebastianTill, AndreasQuarleri, Jorge FabianHIVASTROCITOSINFLAMASOMAPIROPTOSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associated with neuroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled (Rawat et al., 2019).Fil: Ojeda, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; ArgentinaFil: Till, Andreas. Universitat Bonn; AlemaniaFil: Quarleri, Jorge Fabian. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaShenyang Editorial Dept Neural Regeneration Res2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112181Ojeda, Diego Sebastian; Till, Andreas; Quarleri, Jorge Fabian; Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 10; 10-2019; 1707-17081673-5374CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.257519info:eu-repo/semantics/altIdentifier/url/http://www.nrronline.org/text.asp?2019/14/10/1707/257519info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585541/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:12Zoai:ri.conicet.gov.ar:11336/112181instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:12.653CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
title Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
spellingShingle Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
Ojeda, Diego Sebastian
HIV
ASTROCITOS
INFLAMASOMA
PIROPTOSIS
title_short Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
title_full Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
title_fullStr Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
title_full_unstemmed Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
title_sort Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
dc.creator.none.fl_str_mv Ojeda, Diego Sebastian
Till, Andreas
Quarleri, Jorge Fabian
author Ojeda, Diego Sebastian
author_facet Ojeda, Diego Sebastian
Till, Andreas
Quarleri, Jorge Fabian
author_role author
author2 Till, Andreas
Quarleri, Jorge Fabian
author2_role author
author
dc.subject.none.fl_str_mv HIV
ASTROCITOS
INFLAMASOMA
PIROPTOSIS
topic HIV
ASTROCITOS
INFLAMASOMA
PIROPTOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associated with neuroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled (Rawat et al., 2019).
Fil: Ojeda, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires; Argentina
Fil: Till, Andreas. Universitat Bonn; Alemania
Fil: Quarleri, Jorge Fabian. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associated with neuroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled (Rawat et al., 2019).
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112181
Ojeda, Diego Sebastian; Till, Andreas; Quarleri, Jorge Fabian; Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 10; 10-2019; 1707-1708
1673-5374
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112181
identifier_str_mv Ojeda, Diego Sebastian; Till, Andreas; Quarleri, Jorge Fabian; Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 10; 10-2019; 1707-1708
1673-5374
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.257519
info:eu-repo/semantics/altIdentifier/url/http://www.nrronline.org/text.asp?2019/14/10/1707/257519
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585541/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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