Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia

Autores
Lev, Paola Roxana; Goette, Nora Paula; Marta, Rosana Fernanda
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the decrease in peripheral blood platelet count below 100 x 109/L, and an increased bleeding risk when thrombocytopenia drops below 30 x 109/L. The mechanisms leading to ITP in adults, although not completely elucidated, involves an imbalance between effector and regulatory cells that results in a breakdown of the immune tolerance. Autoantibodies are considered the main responsible for thrombocytopenia, although direct T-cell cytotoxic effect and lysis by Complement attachment and activation could also contribute to platelet elimination from circulation. In addition to increased peripheral clearance, abnormalities in platelet production also favors platelet count reduction. This review is intended to describe some specific knowledge about peripheral and bone marrow mechanisms leading to thrombocytopenia in adult ITP.
Fil: Lev, Paola Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Goette, Nora Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Marta, Rosana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
IMMUNE THROMBOCYTOPENIA
PLATELETS
MEGAKARYOCYTES
AUTOANTIBODIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130454
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Pathophysiological mechanisms leading to low platelet count in immune thrombocytopeniaLev, Paola RoxanaGoette, Nora PaulaMarta, Rosana FernandaIMMUNE THROMBOCYTOPENIAPLATELETSMEGAKARYOCYTESAUTOANTIBODIEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the decrease in peripheral blood platelet count below 100 x 109/L, and an increased bleeding risk when thrombocytopenia drops below 30 x 109/L. The mechanisms leading to ITP in adults, although not completely elucidated, involves an imbalance between effector and regulatory cells that results in a breakdown of the immune tolerance. Autoantibodies are considered the main responsible for thrombocytopenia, although direct T-cell cytotoxic effect and lysis by Complement attachment and activation could also contribute to platelet elimination from circulation. In addition to increased peripheral clearance, abnormalities in platelet production also favors platelet count reduction. This review is intended to describe some specific knowledge about peripheral and bone marrow mechanisms leading to thrombocytopenia in adult ITP.Fil: Lev, Paola Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Goette, Nora Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Marta, Rosana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaJournal of Immunological Science2020-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130454Lev, Paola Roxana; Goette, Nora Paula; Marta, Rosana Fernanda; Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia; Journal of Immunological Science; Journal of Immunological Science; 4; 2; 1-7-2020; 1-72578-3009CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.29245/2578-3009/2020/2.1185info:eu-repo/semantics/altIdentifier/url/https://www.immunologyresearchjournal.com/articles/pathophysiological-mechanisms-leading-to-low-platelet-count-in-immune-thrombocytopenia.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:21Zoai:ri.conicet.gov.ar:11336/130454instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:21.585CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
title Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
spellingShingle Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
Lev, Paola Roxana
IMMUNE THROMBOCYTOPENIA
PLATELETS
MEGAKARYOCYTES
AUTOANTIBODIES
title_short Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
title_full Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
title_fullStr Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
title_full_unstemmed Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
title_sort Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
dc.creator.none.fl_str_mv Lev, Paola Roxana
Goette, Nora Paula
Marta, Rosana Fernanda
author Lev, Paola Roxana
author_facet Lev, Paola Roxana
Goette, Nora Paula
Marta, Rosana Fernanda
author_role author
author2 Goette, Nora Paula
Marta, Rosana Fernanda
author2_role author
author
dc.subject.none.fl_str_mv IMMUNE THROMBOCYTOPENIA
PLATELETS
MEGAKARYOCYTES
AUTOANTIBODIES
topic IMMUNE THROMBOCYTOPENIA
PLATELETS
MEGAKARYOCYTES
AUTOANTIBODIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the decrease in peripheral blood platelet count below 100 x 109/L, and an increased bleeding risk when thrombocytopenia drops below 30 x 109/L. The mechanisms leading to ITP in adults, although not completely elucidated, involves an imbalance between effector and regulatory cells that results in a breakdown of the immune tolerance. Autoantibodies are considered the main responsible for thrombocytopenia, although direct T-cell cytotoxic effect and lysis by Complement attachment and activation could also contribute to platelet elimination from circulation. In addition to increased peripheral clearance, abnormalities in platelet production also favors platelet count reduction. This review is intended to describe some specific knowledge about peripheral and bone marrow mechanisms leading to thrombocytopenia in adult ITP.
Fil: Lev, Paola Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Goette, Nora Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Marta, Rosana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the decrease in peripheral blood platelet count below 100 x 109/L, and an increased bleeding risk when thrombocytopenia drops below 30 x 109/L. The mechanisms leading to ITP in adults, although not completely elucidated, involves an imbalance between effector and regulatory cells that results in a breakdown of the immune tolerance. Autoantibodies are considered the main responsible for thrombocytopenia, although direct T-cell cytotoxic effect and lysis by Complement attachment and activation could also contribute to platelet elimination from circulation. In addition to increased peripheral clearance, abnormalities in platelet production also favors platelet count reduction. This review is intended to describe some specific knowledge about peripheral and bone marrow mechanisms leading to thrombocytopenia in adult ITP.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130454
Lev, Paola Roxana; Goette, Nora Paula; Marta, Rosana Fernanda; Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia; Journal of Immunological Science; Journal of Immunological Science; 4; 2; 1-7-2020; 1-7
2578-3009
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130454
identifier_str_mv Lev, Paola Roxana; Goette, Nora Paula; Marta, Rosana Fernanda; Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia; Journal of Immunological Science; Journal of Immunological Science; 4; 2; 1-7-2020; 1-7
2578-3009
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.29245/2578-3009/2020/2.1185
info:eu-repo/semantics/altIdentifier/url/https://www.immunologyresearchjournal.com/articles/pathophysiological-mechanisms-leading-to-low-platelet-count-in-immune-thrombocytopenia.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Immunological Science
publisher.none.fl_str_mv Journal of Immunological Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269798085427200
score 13.13397

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