Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers

Autores
Schattner, Mirta; Rivadeneyra, Leonardo; Pozner, Roberto G.; Gómez, Ricardo Martín
Año de publicación
2013
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
Instituto de Biotecnologia y Biologia Molecular
Materia
Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85432
Acceder
id SEDICI_ffe70ca1c13d986c5827cfa6529aa601
oai_identifier_str oai:sedici.unlp.edu.ar:10915/85432
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic feversSchattner, MirtaRivadeneyra, LeonardoPozner, Roberto G.Gómez, Ricardo MartínBiologíaCoagulationEndotheliumHemostasisInterferonMegakaryocytesNitric oxidePlateletsThrombocytopeniaViral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.Instituto de Biotecnologia y Biologia Molecular2013info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf340-351http://sedici.unlp.edu.ar/handle/10915/85432enginfo:eu-repo/semantics/altIdentifier/issn/1999-4915info:eu-repo/semantics/altIdentifier/doi/10.3390/v5010340info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:48:50Zoai:sedici.unlp.edu.ar:10915/85432Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:48:51.029SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
spellingShingle Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
Schattner, Mirta
Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
title_short Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_full Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_fullStr Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_full_unstemmed Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_sort Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
dc.creator.none.fl_str_mv Schattner, Mirta
Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
author Schattner, Mirta
author_facet Schattner, Mirta
Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
author_role author
author2 Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
author2_role author
author
author
dc.subject.none.fl_str_mv Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
topic Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
dc.description.none.fl_txt_mv Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
Instituto de Biotecnologia y Biologia Molecular
description Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85432
url http://sedici.unlp.edu.ar/handle/10915/85432
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1999-4915
info:eu-repo/semantics/altIdentifier/doi/10.3390/v5010340
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
340-351
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1842260364385845248
score 13.13397

Publicaciones similares