The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas

Autores
Caraballo, Diego Alfredo; Sabio, Maria Soledad; Colombo, Valeria Carolina; Piccirilli, María Guadalupe; Vico, Lorena; Hirmas Riade, Stella Maris; Campos, Josefina; Martínez, Gustavo; Beltrán, Fernando; Baumeister, Elsa; Cisterna, Daniel Marcelo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bats are reservoirs of diverse coronaviruses (CoVs), including progenitors of severe acute respiratory syndrome CoV (SARS-CoV) and SARS-CoV-2. In the Americas, there is a contrast between alphacoronaviruses (alphaCoVs) and betaCoVs: while cospeciation prevails in the latter, alphaCoV evolution is dominated by deep and recent host switches. AlphaCoV lineages are maintained by two different bat family groups, Phyllostomidae and Vespertilionidae plus Molossidae. In this study, we used a Bayesian framework to analyze the process of diversification of the lineages maintained by Molossidae and Vespertilionidae, adding novel CoV sequences from Argentina. We provide evidence that the observed CoV diversity in these two bat families is shaped by their geographic distribution and that CoVs exhibit clustering at the level of bat genera. We discuss the causes of the cocirculation of two independent clades in Molossus and Tadarida as well as the role of Myotis as the ancestral host and a major evolutionary reservoir of alphaCoVs across the continent. Although more CoV sampling efforts are needed, these findings contribute to a better knowledge of the diversity of alphaCoVs and the links between bat host species.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Sabio, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Colombo, Valeria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Vico, Lorena. No especifíca;
Fil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Campos, Josefina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Martínez, Gustavo. No especifíca;
Fil: Beltrán, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Materia
BATS
CORONAVIRUS
CROSS-SPECIES TRANSMISSION
HOST SHIFT
MOLOSSIDAE
PHYLOGENY
SPILLOVER
VESPERTILIONIDAE
VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/213744
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/213744
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the AmericasCaraballo, Diego AlfredoSabio, Maria SoledadColombo, Valeria CarolinaPiccirilli, María GuadalupeVico, LorenaHirmas Riade, Stella MarisCampos, JosefinaMartínez, GustavoBeltrán, FernandoBaumeister, ElsaCisterna, Daniel MarceloBATSCORONAVIRUSCROSS-SPECIES TRANSMISSIONHOST SHIFTMOLOSSIDAEPHYLOGENYSPILLOVERVESPERTILIONIDAEVIRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Bats are reservoirs of diverse coronaviruses (CoVs), including progenitors of severe acute respiratory syndrome CoV (SARS-CoV) and SARS-CoV-2. In the Americas, there is a contrast between alphacoronaviruses (alphaCoVs) and betaCoVs: while cospeciation prevails in the latter, alphaCoV evolution is dominated by deep and recent host switches. AlphaCoV lineages are maintained by two different bat family groups, Phyllostomidae and Vespertilionidae plus Molossidae. In this study, we used a Bayesian framework to analyze the process of diversification of the lineages maintained by Molossidae and Vespertilionidae, adding novel CoV sequences from Argentina. We provide evidence that the observed CoV diversity in these two bat families is shaped by their geographic distribution and that CoVs exhibit clustering at the level of bat genera. We discuss the causes of the cocirculation of two independent clades in Molossus and Tadarida as well as the role of Myotis as the ancestral host and a major evolutionary reservoir of alphaCoVs across the continent. Although more CoV sampling efforts are needed, these findings contribute to a better knowledge of the diversity of alphaCoVs and the links between bat host species.Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Sabio, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Colombo, Valeria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Vico, Lorena. No especifíca;Fil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Campos, Josefina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Martínez, Gustavo. No especifíca;Fil: Beltrán, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaAmerican Society for Microbiology2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/213744Caraballo, Diego Alfredo; Sabio, Maria Soledad; Colombo, Valeria Carolina; Piccirilli, María Guadalupe; Vico, Lorena; et al.; The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas; American Society for Microbiology; Microbiology Spectrum; 10; 6; 10-2022; 1-122165-0497CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/spectrum.03143-22info:eu-repo/semantics/altIdentifier/doi/10.1128/spectrum.03143-22info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:08Zoai:ri.conicet.gov.ar:11336/213744instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:08.793CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
title The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
spellingShingle The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
Caraballo, Diego Alfredo
BATS
CORONAVIRUS
CROSS-SPECIES TRANSMISSION
HOST SHIFT
MOLOSSIDAE
PHYLOGENY
SPILLOVER
VESPERTILIONIDAE
VIRUS
title_short The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
title_full The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
title_fullStr The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
title_full_unstemmed The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
title_sort The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas
dc.creator.none.fl_str_mv Caraballo, Diego Alfredo
Sabio, Maria Soledad
Colombo, Valeria Carolina
Piccirilli, María Guadalupe
Vico, Lorena
Hirmas Riade, Stella Maris
Campos, Josefina
Martínez, Gustavo
Beltrán, Fernando
Baumeister, Elsa
Cisterna, Daniel Marcelo
author Caraballo, Diego Alfredo
author_facet Caraballo, Diego Alfredo
Sabio, Maria Soledad
Colombo, Valeria Carolina
Piccirilli, María Guadalupe
Vico, Lorena
Hirmas Riade, Stella Maris
Campos, Josefina
Martínez, Gustavo
Beltrán, Fernando
Baumeister, Elsa
Cisterna, Daniel Marcelo
author_role author
author2 Sabio, Maria Soledad
Colombo, Valeria Carolina
Piccirilli, María Guadalupe
Vico, Lorena
Hirmas Riade, Stella Maris
Campos, Josefina
Martínez, Gustavo
Beltrán, Fernando
Baumeister, Elsa
Cisterna, Daniel Marcelo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BATS
CORONAVIRUS
CROSS-SPECIES TRANSMISSION
HOST SHIFT
MOLOSSIDAE
PHYLOGENY
SPILLOVER
VESPERTILIONIDAE
VIRUS
topic BATS
CORONAVIRUS
CROSS-SPECIES TRANSMISSION
HOST SHIFT
MOLOSSIDAE
PHYLOGENY
SPILLOVER
VESPERTILIONIDAE
VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Bats are reservoirs of diverse coronaviruses (CoVs), including progenitors of severe acute respiratory syndrome CoV (SARS-CoV) and SARS-CoV-2. In the Americas, there is a contrast between alphacoronaviruses (alphaCoVs) and betaCoVs: while cospeciation prevails in the latter, alphaCoV evolution is dominated by deep and recent host switches. AlphaCoV lineages are maintained by two different bat family groups, Phyllostomidae and Vespertilionidae plus Molossidae. In this study, we used a Bayesian framework to analyze the process of diversification of the lineages maintained by Molossidae and Vespertilionidae, adding novel CoV sequences from Argentina. We provide evidence that the observed CoV diversity in these two bat families is shaped by their geographic distribution and that CoVs exhibit clustering at the level of bat genera. We discuss the causes of the cocirculation of two independent clades in Molossus and Tadarida as well as the role of Myotis as the ancestral host and a major evolutionary reservoir of alphaCoVs across the continent. Although more CoV sampling efforts are needed, these findings contribute to a better knowledge of the diversity of alphaCoVs and the links between bat host species.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Sabio, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Colombo, Valeria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Vico, Lorena. No especifíca;
Fil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Campos, Josefina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Martínez, Gustavo. No especifíca;
Fil: Beltrán, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
description Bats are reservoirs of diverse coronaviruses (CoVs), including progenitors of severe acute respiratory syndrome CoV (SARS-CoV) and SARS-CoV-2. In the Americas, there is a contrast between alphacoronaviruses (alphaCoVs) and betaCoVs: while cospeciation prevails in the latter, alphaCoV evolution is dominated by deep and recent host switches. AlphaCoV lineages are maintained by two different bat family groups, Phyllostomidae and Vespertilionidae plus Molossidae. In this study, we used a Bayesian framework to analyze the process of diversification of the lineages maintained by Molossidae and Vespertilionidae, adding novel CoV sequences from Argentina. We provide evidence that the observed CoV diversity in these two bat families is shaped by their geographic distribution and that CoVs exhibit clustering at the level of bat genera. We discuss the causes of the cocirculation of two independent clades in Molossus and Tadarida as well as the role of Myotis as the ancestral host and a major evolutionary reservoir of alphaCoVs across the continent. Although more CoV sampling efforts are needed, these findings contribute to a better knowledge of the diversity of alphaCoVs and the links between bat host species.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/213744
Caraballo, Diego Alfredo; Sabio, Maria Soledad; Colombo, Valeria Carolina; Piccirilli, María Guadalupe; Vico, Lorena; et al.; The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas; American Society for Microbiology; Microbiology Spectrum; 10; 6; 10-2022; 1-12
2165-0497
CONICET Digital
CONICET
url http://hdl.handle.net/11336/213744
identifier_str_mv Caraballo, Diego Alfredo; Sabio, Maria Soledad; Colombo, Valeria Carolina; Piccirilli, María Guadalupe; Vico, Lorena; et al.; The Role of Molossidae and Vespertilionidae in Shaping the Diversity of Alphacoronaviruses in the Americas; American Society for Microbiology; Microbiology Spectrum; 10; 6; 10-2022; 1-12
2165-0497
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/spectrum.03143-22
info:eu-repo/semantics/altIdentifier/doi/10.1128/spectrum.03143-22
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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