The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis

Autores
Naipauer, Julian; Mesri, Enrique Alfredo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Mesri, Enrique Alfredo. University of Miami; Estados Unidos
Materia
ANGIOGENESIS
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
KAPOSI´S SARCOMA HERPESVIRUS
SARCOMAGENESIS
VIRUS ONCOGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225598
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axisNaipauer, JulianMesri, Enrique AlfredoANGIOGENESISENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXISKAPOSI´S SARCOMA HERPESVIRUSSARCOMAGENESISVIRUS ONCOGENESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Mesri, Enrique Alfredo. University of Miami; Estados UnidosElsevier2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225598Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-2001471-4914CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2022.12.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:58Zoai:ri.conicet.gov.ar:11336/225598instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:59.214CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
title The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
spellingShingle The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
Naipauer, Julian
ANGIOGENESIS
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
KAPOSI´S SARCOMA HERPESVIRUS
SARCOMAGENESIS
VIRUS ONCOGENESIS
title_short The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
title_full The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
title_fullStr The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
title_full_unstemmed The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
title_sort The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
dc.creator.none.fl_str_mv Naipauer, Julian
Mesri, Enrique Alfredo
author Naipauer, Julian
author_facet Naipauer, Julian
Mesri, Enrique Alfredo
author_role author
author2 Mesri, Enrique Alfredo
author2_role author
dc.subject.none.fl_str_mv ANGIOGENESIS
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
KAPOSI´S SARCOMA HERPESVIRUS
SARCOMAGENESIS
VIRUS ONCOGENESIS
topic ANGIOGENESIS
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
KAPOSI´S SARCOMA HERPESVIRUS
SARCOMAGENESIS
VIRUS ONCOGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Mesri, Enrique Alfredo. University of Miami; Estados Unidos
description Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225598
Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200
1471-4914
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225598
identifier_str_mv Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200
1471-4914
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2022.12.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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