The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
- Autores
- Naipauer, Julian; Mesri, Enrique Alfredo
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Mesri, Enrique Alfredo. University of Miami; Estados Unidos - Materia
-
ANGIOGENESIS
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
KAPOSI´S SARCOMA HERPESVIRUS
SARCOMAGENESIS
VIRUS ONCOGENESIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/225598
Ver los metadatos del registro completo
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The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axisNaipauer, JulianMesri, Enrique AlfredoANGIOGENESISENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXISKAPOSI´S SARCOMA HERPESVIRUSSARCOMAGENESISVIRUS ONCOGENESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Mesri, Enrique Alfredo. University of Miami; Estados UnidosElsevier2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225598Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-2001471-4914CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2022.12.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:48Zoai:ri.conicet.gov.ar:11336/225598instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:49.292CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
title |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
spellingShingle |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis Naipauer, Julian ANGIOGENESIS ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS KAPOSI´S SARCOMA HERPESVIRUS SARCOMAGENESIS VIRUS ONCOGENESIS |
title_short |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
title_full |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
title_fullStr |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
title_full_unstemmed |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
title_sort |
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis |
dc.creator.none.fl_str_mv |
Naipauer, Julian Mesri, Enrique Alfredo |
author |
Naipauer, Julian |
author_facet |
Naipauer, Julian Mesri, Enrique Alfredo |
author_role |
author |
author2 |
Mesri, Enrique Alfredo |
author2_role |
author |
dc.subject.none.fl_str_mv |
ANGIOGENESIS ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS KAPOSI´S SARCOMA HERPESVIRUS SARCOMAGENESIS VIRUS ONCOGENESIS |
topic |
ANGIOGENESIS ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS KAPOSI´S SARCOMA HERPESVIRUS SARCOMAGENESIS VIRUS ONCOGENESIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS. Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Mesri, Enrique Alfredo. University of Miami; Estados Unidos |
description |
Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/225598 Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200 1471-4914 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/225598 |
identifier_str_mv |
Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200 1471-4914 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2022.12.003 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |