Body mass index and human sperm quality: Neither one extreme nor the other
- Autores
- Luque, Eugenia Mercedes; Tissera, Andrea D.; Gaggino, M. P.; Molina, Rosa I.; Mangeaud, Adolfo; Vincenti, Laura María; Beltramone, Fernando; Sad Larcher, José; Estofán, Daniel; Fiol De Cuneo, Marta; Martini, Ana Carolina
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of the present study was to investigate the still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18-65 years; non-smokers and non-drinkers), were classified according to BMI as either underweight (UW; BMI <20kgm-2; n≤45), normal weight (NW; BMI 20-24.9kgm-2; n≤1330), overweight (OW; BMI 25-29.9kgm-2; n≤2493), obese (OB; BMI 30-39.9kgm-2; n≤926) or morbidly obese (MOB; BMI ≥40kgm-2; n≤57). Conventional semen parameters and seminal concentrations of fructose, citric acid and neutral -glucosidase (NAG) were evaluated. The four parameters that reflect epididymal maturation were significantly lower in the UW and MOB groups compared with NW, OW and OB groups: sperm concentration, total sperm count (103.3±11.4 and 121.5±20.6 and vs 157.9±3.6, 152.4±2.7 or 142.1±4.3 spermatozoa ejaculate-1 respectively, P<0.05), motility (41.8±2.5 and 42.6±2.6 vs 47.8±0.5, 48.0±0.4 or 46.3±0.6 % of motile spermatozoa respectively, P<0.05) and NAG (45.2±6.6 and 60.1±7.9 vs 71.5±1.9, 64.7±1.3 or 63.1±2.1 mU ejaculate-1 respectively, P<0.05). Moreover, the percentage of morphologically normal spermatozoa was decreased in the MOB group compared with the UW, NW, OW and OB groups (4.8±0.6% vs 6.0±0.8%, 6.9±0.1%, 6.8±0.1 and 6.4±0.2%, respectively; P<0.05). In addition, men in the MOB group had an increased risk (2.3-to 4.9-fold greater) of suffering oligospermia and teratospermia (P<0.05). Both morbid obesity and being underweight have a negative effect on sperm quality, particularly epididymal maturation. These results show the importance of an adequate or normal bodyweight as the natural best option for fertility, with both extremes of the BMI scale as negative prognostic factors.
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Tissera, Andrea D.. Laboratorio de Andrología y Reproducción; Argentina
Fil: Gaggino, M. P.. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina
Fil: Molina, Rosa I.. Laboratorio de Andrología y Reproducción (lar); Argentina
Fil: Mangeaud, Adolfo. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Matemáticas. Cátedra de Estadística y Biometria; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Fisiología Humana; Argentina
Fil: Beltramone, Fernando. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina
Fil: Sad Larcher, José. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina
Fil: Estofán, Daniel. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina
Fil: Fiol De Cuneo, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina - Materia
-
Asthenozoospermia
Epididymal Maturation
Epididymis
Morbid Obesity
Obesity
Oligozoospermia
Teratozoospermia
Underweight - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/57673
Ver los metadatos del registro completo
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Body mass index and human sperm quality: Neither one extreme nor the otherLuque, Eugenia MercedesTissera, Andrea D.Gaggino, M. P.Molina, Rosa I.Mangeaud, AdolfoVincenti, Laura MaríaBeltramone, FernandoSad Larcher, JoséEstofán, DanielFiol De Cuneo, MartaMartini, Ana CarolinaAsthenozoospermiaEpididymal MaturationEpididymisMorbid ObesityObesityOligozoospermiaTeratozoospermiaUnderweighthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The aim of the present study was to investigate the still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18-65 years; non-smokers and non-drinkers), were classified according to BMI as either underweight (UW; BMI <20kgm-2; n≤45), normal weight (NW; BMI 20-24.9kgm-2; n≤1330), overweight (OW; BMI 25-29.9kgm-2; n≤2493), obese (OB; BMI 30-39.9kgm-2; n≤926) or morbidly obese (MOB; BMI ≥40kgm-2; n≤57). Conventional semen parameters and seminal concentrations of fructose, citric acid and neutral -glucosidase (NAG) were evaluated. The four parameters that reflect epididymal maturation were significantly lower in the UW and MOB groups compared with NW, OW and OB groups: sperm concentration, total sperm count (103.3±11.4 and 121.5±20.6 and vs 157.9±3.6, 152.4±2.7 or 142.1±4.3 spermatozoa ejaculate-1 respectively, P<0.05), motility (41.8±2.5 and 42.6±2.6 vs 47.8±0.5, 48.0±0.4 or 46.3±0.6 % of motile spermatozoa respectively, P<0.05) and NAG (45.2±6.6 and 60.1±7.9 vs 71.5±1.9, 64.7±1.3 or 63.1±2.1 mU ejaculate-1 respectively, P<0.05). Moreover, the percentage of morphologically normal spermatozoa was decreased in the MOB group compared with the UW, NW, OW and OB groups (4.8±0.6% vs 6.0±0.8%, 6.9±0.1%, 6.8±0.1 and 6.4±0.2%, respectively; P<0.05). In addition, men in the MOB group had an increased risk (2.3-to 4.9-fold greater) of suffering oligospermia and teratospermia (P<0.05). Both morbid obesity and being underweight have a negative effect on sperm quality, particularly epididymal maturation. These results show the importance of an adequate or normal bodyweight as the natural best option for fertility, with both extremes of the BMI scale as negative prognostic factors.Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Tissera, Andrea D.. Laboratorio de Andrología y Reproducción; ArgentinaFil: Gaggino, M. P.. Centro Integral de Ginecología, Obstetricia y Reproducc; ArgentinaFil: Molina, Rosa I.. Laboratorio de Andrología y Reproducción (lar); ArgentinaFil: Mangeaud, Adolfo. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Matemáticas. Cátedra de Estadística y Biometria; ArgentinaFil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Fisiología Humana; ArgentinaFil: Beltramone, Fernando. Centro Integral de Ginecología, Obstetricia y Reproducc; ArgentinaFil: Sad Larcher, José. Centro Integral de Ginecología, Obstetricia y Reproducc; ArgentinaFil: Estofán, Daniel. Centro Integral de Ginecología, Obstetricia y Reproducc; ArgentinaFil: Fiol De Cuneo, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaCsiro Publishing2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57673Luque, Eugenia Mercedes; Tissera, Andrea D.; Gaggino, M. P.; Molina, Rosa I.; Mangeaud, Adolfo; et al.; Body mass index and human sperm quality: Neither one extreme nor the other; Csiro Publishing; Reproduction Fertility and Development; 29; 4; 12-2015; 731-7391031-36131448-5990CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26678380info:eu-repo/semantics/altIdentifier/doi/10.1071/RD15351info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:01:26Zoai:ri.conicet.gov.ar:11336/57673instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:01:26.48CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Body mass index and human sperm quality: Neither one extreme nor the other |
| title |
Body mass index and human sperm quality: Neither one extreme nor the other |
| spellingShingle |
Body mass index and human sperm quality: Neither one extreme nor the other Luque, Eugenia Mercedes Asthenozoospermia Epididymal Maturation Epididymis Morbid Obesity Obesity Oligozoospermia Teratozoospermia Underweight |
| title_short |
Body mass index and human sperm quality: Neither one extreme nor the other |
| title_full |
Body mass index and human sperm quality: Neither one extreme nor the other |
| title_fullStr |
Body mass index and human sperm quality: Neither one extreme nor the other |
| title_full_unstemmed |
Body mass index and human sperm quality: Neither one extreme nor the other |
| title_sort |
Body mass index and human sperm quality: Neither one extreme nor the other |
| dc.creator.none.fl_str_mv |
Luque, Eugenia Mercedes Tissera, Andrea D. Gaggino, M. P. Molina, Rosa I. Mangeaud, Adolfo Vincenti, Laura María Beltramone, Fernando Sad Larcher, José Estofán, Daniel Fiol De Cuneo, Marta Martini, Ana Carolina |
| author |
Luque, Eugenia Mercedes |
| author_facet |
Luque, Eugenia Mercedes Tissera, Andrea D. Gaggino, M. P. Molina, Rosa I. Mangeaud, Adolfo Vincenti, Laura María Beltramone, Fernando Sad Larcher, José Estofán, Daniel Fiol De Cuneo, Marta Martini, Ana Carolina |
| author_role |
author |
| author2 |
Tissera, Andrea D. Gaggino, M. P. Molina, Rosa I. Mangeaud, Adolfo Vincenti, Laura María Beltramone, Fernando Sad Larcher, José Estofán, Daniel Fiol De Cuneo, Marta Martini, Ana Carolina |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Asthenozoospermia Epididymal Maturation Epididymis Morbid Obesity Obesity Oligozoospermia Teratozoospermia Underweight |
| topic |
Asthenozoospermia Epididymal Maturation Epididymis Morbid Obesity Obesity Oligozoospermia Teratozoospermia Underweight |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
The aim of the present study was to investigate the still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18-65 years; non-smokers and non-drinkers), were classified according to BMI as either underweight (UW; BMI <20kgm-2; n≤45), normal weight (NW; BMI 20-24.9kgm-2; n≤1330), overweight (OW; BMI 25-29.9kgm-2; n≤2493), obese (OB; BMI 30-39.9kgm-2; n≤926) or morbidly obese (MOB; BMI ≥40kgm-2; n≤57). Conventional semen parameters and seminal concentrations of fructose, citric acid and neutral -glucosidase (NAG) were evaluated. The four parameters that reflect epididymal maturation were significantly lower in the UW and MOB groups compared with NW, OW and OB groups: sperm concentration, total sperm count (103.3±11.4 and 121.5±20.6 and vs 157.9±3.6, 152.4±2.7 or 142.1±4.3 spermatozoa ejaculate-1 respectively, P<0.05), motility (41.8±2.5 and 42.6±2.6 vs 47.8±0.5, 48.0±0.4 or 46.3±0.6 % of motile spermatozoa respectively, P<0.05) and NAG (45.2±6.6 and 60.1±7.9 vs 71.5±1.9, 64.7±1.3 or 63.1±2.1 mU ejaculate-1 respectively, P<0.05). Moreover, the percentage of morphologically normal spermatozoa was decreased in the MOB group compared with the UW, NW, OW and OB groups (4.8±0.6% vs 6.0±0.8%, 6.9±0.1%, 6.8±0.1 and 6.4±0.2%, respectively; P<0.05). In addition, men in the MOB group had an increased risk (2.3-to 4.9-fold greater) of suffering oligospermia and teratospermia (P<0.05). Both morbid obesity and being underweight have a negative effect on sperm quality, particularly epididymal maturation. These results show the importance of an adequate or normal bodyweight as the natural best option for fertility, with both extremes of the BMI scale as negative prognostic factors. Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Tissera, Andrea D.. Laboratorio de Andrología y Reproducción; Argentina Fil: Gaggino, M. P.. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina Fil: Molina, Rosa I.. Laboratorio de Andrología y Reproducción (lar); Argentina Fil: Mangeaud, Adolfo. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Matemáticas. Cátedra de Estadística y Biometria; Argentina Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomedica. Cátedra de Fisiología Humana; Argentina Fil: Beltramone, Fernando. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina Fil: Sad Larcher, José. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina Fil: Estofán, Daniel. Centro Integral de Ginecología, Obstetricia y Reproducc; Argentina Fil: Fiol De Cuneo, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina |
| description |
The aim of the present study was to investigate the still contentious association between body mass index (BMI) and seminal quality. To this end, 4860 male patients (aged 18-65 years; non-smokers and non-drinkers), were classified according to BMI as either underweight (UW; BMI <20kgm-2; n≤45), normal weight (NW; BMI 20-24.9kgm-2; n≤1330), overweight (OW; BMI 25-29.9kgm-2; n≤2493), obese (OB; BMI 30-39.9kgm-2; n≤926) or morbidly obese (MOB; BMI ≥40kgm-2; n≤57). Conventional semen parameters and seminal concentrations of fructose, citric acid and neutral -glucosidase (NAG) were evaluated. The four parameters that reflect epididymal maturation were significantly lower in the UW and MOB groups compared with NW, OW and OB groups: sperm concentration, total sperm count (103.3±11.4 and 121.5±20.6 and vs 157.9±3.6, 152.4±2.7 or 142.1±4.3 spermatozoa ejaculate-1 respectively, P<0.05), motility (41.8±2.5 and 42.6±2.6 vs 47.8±0.5, 48.0±0.4 or 46.3±0.6 % of motile spermatozoa respectively, P<0.05) and NAG (45.2±6.6 and 60.1±7.9 vs 71.5±1.9, 64.7±1.3 or 63.1±2.1 mU ejaculate-1 respectively, P<0.05). Moreover, the percentage of morphologically normal spermatozoa was decreased in the MOB group compared with the UW, NW, OW and OB groups (4.8±0.6% vs 6.0±0.8%, 6.9±0.1%, 6.8±0.1 and 6.4±0.2%, respectively; P<0.05). In addition, men in the MOB group had an increased risk (2.3-to 4.9-fold greater) of suffering oligospermia and teratospermia (P<0.05). Both morbid obesity and being underweight have a negative effect on sperm quality, particularly epididymal maturation. These results show the importance of an adequate or normal bodyweight as the natural best option for fertility, with both extremes of the BMI scale as negative prognostic factors. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-12 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/57673 Luque, Eugenia Mercedes; Tissera, Andrea D.; Gaggino, M. P.; Molina, Rosa I.; Mangeaud, Adolfo; et al.; Body mass index and human sperm quality: Neither one extreme nor the other; Csiro Publishing; Reproduction Fertility and Development; 29; 4; 12-2015; 731-739 1031-3613 1448-5990 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/57673 |
| identifier_str_mv |
Luque, Eugenia Mercedes; Tissera, Andrea D.; Gaggino, M. P.; Molina, Rosa I.; Mangeaud, Adolfo; et al.; Body mass index and human sperm quality: Neither one extreme nor the other; Csiro Publishing; Reproduction Fertility and Development; 29; 4; 12-2015; 731-739 1031-3613 1448-5990 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26678380 info:eu-repo/semantics/altIdentifier/doi/10.1071/RD15351 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Csiro Publishing |
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Csiro Publishing |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |