Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum

Autores
Simao Gurge, Raquel; Cricco, Julia Alejandra; Wunderlich, Gerhard; Kimura, Emilia; Cirulli, Brenda Analía; Katzin, Alejandro
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase? (HOS or Cox10) and ?heme A synthase? (HAS or Cox15). The identification of heme O and heme A and characterization of enzymes involved in their synthesis are important for exploring the possible products biosynthesized by the parasite derived from the MEP pathway. Importantly, hemes A and O are essential molecules for numerous living organisms, since they are critical components of the mitochondrial electron transport chain, catalyzing the reduction of O2 to H2O. Additionally, the heme group is an important target of drugs such as artemisinin and quinolines.
Fil: Simao Gurge, Raquel. Universidade de Sao Paulo; Brasil
Fil: Cricco, Julia Alejandra. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wunderlich, Gerhard. Universidade de Sao Paulo; Brasil
Fil: Kimura, Emilia. Universidade de Sao Paulo; Brasil
Fil: Cirulli, Brenda Analía. Universidad Nacional de Rosario; Argentina
Fil: Katzin, Alejandro. Universidade de Sao Paulo; Brasil
Materia
PLASMODIUM FALCIPARUM
HEME A SINTHESIS
HEME O SINTHESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29622
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparumSimao Gurge, RaquelCricco, Julia AlejandraWunderlich, GerhardKimura, EmiliaCirulli, Brenda AnalíaKatzin, AlejandroPLASMODIUM FALCIPARUMHEME A SINTHESISHEME O SINTHESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase? (HOS or Cox10) and ?heme A synthase? (HAS or Cox15). The identification of heme O and heme A and characterization of enzymes involved in their synthesis are important for exploring the possible products biosynthesized by the parasite derived from the MEP pathway. Importantly, hemes A and O are essential molecules for numerous living organisms, since they are critical components of the mitochondrial electron transport chain, catalyzing the reduction of O2 to H2O. Additionally, the heme group is an important target of drugs such as artemisinin and quinolines.Fil: Simao Gurge, Raquel. Universidade de Sao Paulo; BrasilFil: Cricco, Julia Alejandra. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wunderlich, Gerhard. Universidade de Sao Paulo; BrasilFil: Kimura, Emilia. Universidade de Sao Paulo; BrasilFil: Cirulli, Brenda Analía. Universidad Nacional de Rosario; ArgentinaFil: Katzin, Alejandro. Universidade de Sao Paulo; BrasilBioMed Central2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29622Simao Gurge, Raquel; Cricco, Julia Alejandra; Wunderlich, Gerhard; Kimura, Emilia; Cirulli, Brenda Analía; et al.; Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum; BioMed Central; Malaria Journal; 13; 1; 9-2014; 82-821475-2875CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/1475-2875-13-S1-P82info:eu-repo/semantics/altIdentifier/url/https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-S1-P82info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:53Zoai:ri.conicet.gov.ar:11336/29622instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:54.281CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
title Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
spellingShingle Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
Simao Gurge, Raquel
PLASMODIUM FALCIPARUM
HEME A SINTHESIS
HEME O SINTHESIS
title_short Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
title_full Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
title_fullStr Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
title_full_unstemmed Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
title_sort Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum
dc.creator.none.fl_str_mv Simao Gurge, Raquel
Cricco, Julia Alejandra
Wunderlich, Gerhard
Kimura, Emilia
Cirulli, Brenda Analía
Katzin, Alejandro
author Simao Gurge, Raquel
author_facet Simao Gurge, Raquel
Cricco, Julia Alejandra
Wunderlich, Gerhard
Kimura, Emilia
Cirulli, Brenda Analía
Katzin, Alejandro
author_role author
author2 Cricco, Julia Alejandra
Wunderlich, Gerhard
Kimura, Emilia
Cirulli, Brenda Analía
Katzin, Alejandro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv PLASMODIUM FALCIPARUM
HEME A SINTHESIS
HEME O SINTHESIS
topic PLASMODIUM FALCIPARUM
HEME A SINTHESIS
HEME O SINTHESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase? (HOS or Cox10) and ?heme A synthase? (HAS or Cox15). The identification of heme O and heme A and characterization of enzymes involved in their synthesis are important for exploring the possible products biosynthesized by the parasite derived from the MEP pathway. Importantly, hemes A and O are essential molecules for numerous living organisms, since they are critical components of the mitochondrial electron transport chain, catalyzing the reduction of O2 to H2O. Additionally, the heme group is an important target of drugs such as artemisinin and quinolines.
Fil: Simao Gurge, Raquel. Universidade de Sao Paulo; Brasil
Fil: Cricco, Julia Alejandra. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wunderlich, Gerhard. Universidade de Sao Paulo; Brasil
Fil: Kimura, Emilia. Universidade de Sao Paulo; Brasil
Fil: Cirulli, Brenda Analía. Universidad Nacional de Rosario; Argentina
Fil: Katzin, Alejandro. Universidade de Sao Paulo; Brasil
description Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase? (HOS or Cox10) and ?heme A synthase? (HAS or Cox15). The identification of heme O and heme A and characterization of enzymes involved in their synthesis are important for exploring the possible products biosynthesized by the parasite derived from the MEP pathway. Importantly, hemes A and O are essential molecules for numerous living organisms, since they are critical components of the mitochondrial electron transport chain, catalyzing the reduction of O2 to H2O. Additionally, the heme group is an important target of drugs such as artemisinin and quinolines.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29622
Simao Gurge, Raquel; Cricco, Julia Alejandra; Wunderlich, Gerhard; Kimura, Emilia; Cirulli, Brenda Analía; et al.; Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum; BioMed Central; Malaria Journal; 13; 1; 9-2014; 82-82
1475-2875
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29622
identifier_str_mv Simao Gurge, Raquel; Cricco, Julia Alejandra; Wunderlich, Gerhard; Kimura, Emilia; Cirulli, Brenda Analía; et al.; Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum; BioMed Central; Malaria Journal; 13; 1; 9-2014; 82-82
1475-2875
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/1475-2875-13-S1-P82
info:eu-repo/semantics/altIdentifier/url/https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-S1-P82
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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