Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm

Autores
Suhaiman, Laila; Belmonte, Silvia Alejandra
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It has long been thought that exocytosis was driven exclusively by well-studiedfusion proteins. Some decades ago, the role of lipids became evident andescalated interest in the field. Our laboratory chose a particular cell to facethis issue: the human sperm. What makes this cell special? Sperm, as terminalcells, are characterized by their scarcity of organelles and the complete absenceof transcriptional and translational activities. They are specialized for a singularmembrane fusion occurrence: the exocytosis of the acrosome. This unique traitmakes them invaluable for the study of exocytosis in isolation. We will discuss thelipids’ role in human sperm acrosome exocytosis from various perspectives, witha primary emphasis on our contributions to the field. Sperm cells have a uniquelipid composition, very rare and not observed in many cell types, comprising ahigh content of plasmalogens, long-chain, and very-long-chain polyunsaturatedfatty acids that are particular constituents of some sphingolipids. This reviewendeavors to unravel the impact of membrane lipid composition on the properfunctioning of the exocytic pathway in human sperm and how this lipid dynamicinfluences its fertilizing capability. Evidence from our and other laboratoriesallowed unveiling the role and importance of multiple lipids that driveexocytosis. This review highlights the role of cholesterol, diacylglycerol, andparticular phospholipids like phosphatidic acid, phosphatidylinositol 4,5-bisphosphate, and sphingolipids in driving sperm acrosome exocytosis.Furthermore, we provide a comprehensive overview of the factors and enzymesthat regulate lipid turnover during the exocytic course. A more thorough grasp ofthe role played by lipids transferred from sperm can provide insights into certaincauses of male infertility. It may lead to enhancements in diagnosing infertility andtechniques like assisted reproductive technology (ART).
Fil: Suhaiman, Laila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Belmonte, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Materia
ACROSOME EXOCYTOSIS
HUMAN SPERM
LIPIDS
CHOLESTEROL
SPHINGOLIPIDS
PHOSPHOLIPIDS
MEMBRANE FUSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/259608
Acceder
id CONICETDig_790390c85e351393d2b9ec87f9a6b201
oai_identifier_str oai:ri.conicet.gov.ar:11336/259608
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lipid remodeling in acrosome exocytosis: unraveling key players in the human spermSuhaiman, LailaBelmonte, Silvia AlejandraACROSOME EXOCYTOSISHUMAN SPERMLIPIDSCHOLESTEROLSPHINGOLIPIDSPHOSPHOLIPIDSMEMBRANE FUSIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It has long been thought that exocytosis was driven exclusively by well-studiedfusion proteins. Some decades ago, the role of lipids became evident andescalated interest in the field. Our laboratory chose a particular cell to facethis issue: the human sperm. What makes this cell special? Sperm, as terminalcells, are characterized by their scarcity of organelles and the complete absenceof transcriptional and translational activities. They are specialized for a singularmembrane fusion occurrence: the exocytosis of the acrosome. This unique traitmakes them invaluable for the study of exocytosis in isolation. We will discuss thelipids’ role in human sperm acrosome exocytosis from various perspectives, witha primary emphasis on our contributions to the field. Sperm cells have a uniquelipid composition, very rare and not observed in many cell types, comprising ahigh content of plasmalogens, long-chain, and very-long-chain polyunsaturatedfatty acids that are particular constituents of some sphingolipids. This reviewendeavors to unravel the impact of membrane lipid composition on the properfunctioning of the exocytic pathway in human sperm and how this lipid dynamicinfluences its fertilizing capability. Evidence from our and other laboratoriesallowed unveiling the role and importance of multiple lipids that driveexocytosis. This review highlights the role of cholesterol, diacylglycerol, andparticular phospholipids like phosphatidic acid, phosphatidylinositol 4,5-bisphosphate, and sphingolipids in driving sperm acrosome exocytosis.Furthermore, we provide a comprehensive overview of the factors and enzymesthat regulate lipid turnover during the exocytic course. A more thorough grasp ofthe role played by lipids transferred from sperm can provide insights into certaincauses of male infertility. It may lead to enhancements in diagnosing infertility andtechniques like assisted reproductive technology (ART).Fil: Suhaiman, Laila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Belmonte, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFrontiers Media2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/259608Suhaiman, Laila; Belmonte, Silvia Alejandra; Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm; Frontiers Media; Frontiers in Cell and Developmental Biology; 12; 9-2024; 1-162296-634XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2024.1457638/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2024.1457638info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:20Zoai:ri.conicet.gov.ar:11336/259608instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:20.636CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
title Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
spellingShingle Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
Suhaiman, Laila
ACROSOME EXOCYTOSIS
HUMAN SPERM
LIPIDS
CHOLESTEROL
SPHINGOLIPIDS
PHOSPHOLIPIDS
MEMBRANE FUSION
title_short Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
title_full Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
title_fullStr Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
title_full_unstemmed Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
title_sort Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm
dc.creator.none.fl_str_mv Suhaiman, Laila
Belmonte, Silvia Alejandra
author Suhaiman, Laila
author_facet Suhaiman, Laila
Belmonte, Silvia Alejandra
author_role author
author2 Belmonte, Silvia Alejandra
author2_role author
dc.subject.none.fl_str_mv ACROSOME EXOCYTOSIS
HUMAN SPERM
LIPIDS
CHOLESTEROL
SPHINGOLIPIDS
PHOSPHOLIPIDS
MEMBRANE FUSION
topic ACROSOME EXOCYTOSIS
HUMAN SPERM
LIPIDS
CHOLESTEROL
SPHINGOLIPIDS
PHOSPHOLIPIDS
MEMBRANE FUSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It has long been thought that exocytosis was driven exclusively by well-studiedfusion proteins. Some decades ago, the role of lipids became evident andescalated interest in the field. Our laboratory chose a particular cell to facethis issue: the human sperm. What makes this cell special? Sperm, as terminalcells, are characterized by their scarcity of organelles and the complete absenceof transcriptional and translational activities. They are specialized for a singularmembrane fusion occurrence: the exocytosis of the acrosome. This unique traitmakes them invaluable for the study of exocytosis in isolation. We will discuss thelipids’ role in human sperm acrosome exocytosis from various perspectives, witha primary emphasis on our contributions to the field. Sperm cells have a uniquelipid composition, very rare and not observed in many cell types, comprising ahigh content of plasmalogens, long-chain, and very-long-chain polyunsaturatedfatty acids that are particular constituents of some sphingolipids. This reviewendeavors to unravel the impact of membrane lipid composition on the properfunctioning of the exocytic pathway in human sperm and how this lipid dynamicinfluences its fertilizing capability. Evidence from our and other laboratoriesallowed unveiling the role and importance of multiple lipids that driveexocytosis. This review highlights the role of cholesterol, diacylglycerol, andparticular phospholipids like phosphatidic acid, phosphatidylinositol 4,5-bisphosphate, and sphingolipids in driving sperm acrosome exocytosis.Furthermore, we provide a comprehensive overview of the factors and enzymesthat regulate lipid turnover during the exocytic course. A more thorough grasp ofthe role played by lipids transferred from sperm can provide insights into certaincauses of male infertility. It may lead to enhancements in diagnosing infertility andtechniques like assisted reproductive technology (ART).
Fil: Suhaiman, Laila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Belmonte, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
description It has long been thought that exocytosis was driven exclusively by well-studiedfusion proteins. Some decades ago, the role of lipids became evident andescalated interest in the field. Our laboratory chose a particular cell to facethis issue: the human sperm. What makes this cell special? Sperm, as terminalcells, are characterized by their scarcity of organelles and the complete absenceof transcriptional and translational activities. They are specialized for a singularmembrane fusion occurrence: the exocytosis of the acrosome. This unique traitmakes them invaluable for the study of exocytosis in isolation. We will discuss thelipids’ role in human sperm acrosome exocytosis from various perspectives, witha primary emphasis on our contributions to the field. Sperm cells have a uniquelipid composition, very rare and not observed in many cell types, comprising ahigh content of plasmalogens, long-chain, and very-long-chain polyunsaturatedfatty acids that are particular constituents of some sphingolipids. This reviewendeavors to unravel the impact of membrane lipid composition on the properfunctioning of the exocytic pathway in human sperm and how this lipid dynamicinfluences its fertilizing capability. Evidence from our and other laboratoriesallowed unveiling the role and importance of multiple lipids that driveexocytosis. This review highlights the role of cholesterol, diacylglycerol, andparticular phospholipids like phosphatidic acid, phosphatidylinositol 4,5-bisphosphate, and sphingolipids in driving sperm acrosome exocytosis.Furthermore, we provide a comprehensive overview of the factors and enzymesthat regulate lipid turnover during the exocytic course. A more thorough grasp ofthe role played by lipids transferred from sperm can provide insights into certaincauses of male infertility. It may lead to enhancements in diagnosing infertility andtechniques like assisted reproductive technology (ART).
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/259608
Suhaiman, Laila; Belmonte, Silvia Alejandra; Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm; Frontiers Media; Frontiers in Cell and Developmental Biology; 12; 9-2024; 1-16
2296-634X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/259608
identifier_str_mv Suhaiman, Laila; Belmonte, Silvia Alejandra; Lipid remodeling in acrosome exocytosis: unraveling key players in the human sperm; Frontiers Media; Frontiers in Cell and Developmental Biology; 12; 9-2024; 1-16
2296-634X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2024.1457638/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2024.1457638
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844612986376814592
score 13.070432

Publicaciones similares