Cobalt chloride protects the heart after a global ischemic insult
- Autores
- Gutierrez, Christopher; Farcy, Nicole; Bonazzola, Patricia; Castilla, Rocio Soledad
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Introduction: Ischemia-reperfusion (I/R) is one of the main cardiovascular risk factors and leads to heart contractile and energy dysfunction. I/R-induced damage is reduced by ischemic postconditioning. CoCl₂ has properties to function as a postconditioning agent, since it can trigger transcriptional changes that resemble the response to a hypoxic event under normoxic conditions.Objectives: To evaluate CoCl₂ as a postconditioning therapeutic tool after a myocardial and arterial I/R.Materials and Methods: Isolated adult Wistar rats hearts were arterially perfused at 37ºC by Langendorff method, paced at 3 Hz, exposed to 30 min ischemia followed by 45 min reperfusion (R) in the presence or absence of 0.23 mM CoCl2 which was maintained or removed after 20 min of R.Aortic contractility was evaluated in an isolated organ bath trough incubation with cumulative noradrenaline (NA) doses. After NA washing, 20 min of simulated arterial ischemia (SI) and R with or without CoCl₂ was performed, and NA response was re-evaluated.Results: During R, the presence of CoCl₂ did not alter the cardiac resting pressure, nor the perfusion pressure, but increased the developed pressure (p<0.05) until 20 min which then descend reaching controls values. This decrease was prevented when CoCl₂ was eliminated at 20 min of R. CoCl₂ in R increased the contractile economy (P/Ht) and decreased the cardiac damaged area (p<0.05) and the incidence of arrhythmias (p<0.001).Post-SI arterial contractility increased at the lowest NA dose but not at higher ones. CoCl₂ in post ?SI R did not affect arterial force, but decreased NA sensitivity (EC 50: control: 10-7.5, CoCl2: 10-6.5 M) and the maximum contractile response.Conclusion: The use of CoCl₂ after an ischemic event attenuates the cardiac damage produced at least during the first 25 min of R and reduces the arterial adrenergic contractile response. These results support the use of CoCl₂ as a potential cardioprotective tool of clinical relevance.
Fil: Gutierrez, Christopher. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina
Fil: Farcy, Nicole. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina
Fil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina
Fil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina
LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología - Materia
-
POSTCONDICIONAMIENTO
CLORURO DE COBALTO
CARDIOPROTECCION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/198974
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Cobalt chloride protects the heart after a global ischemic insultGutierrez, ChristopherFarcy, NicoleBonazzola, PatriciaCastilla, Rocio SoledadPOSTCONDICIONAMIENTOCLORURO DE COBALTOCARDIOPROTECCIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Introduction: Ischemia-reperfusion (I/R) is one of the main cardiovascular risk factors and leads to heart contractile and energy dysfunction. I/R-induced damage is reduced by ischemic postconditioning. CoCl₂ has properties to function as a postconditioning agent, since it can trigger transcriptional changes that resemble the response to a hypoxic event under normoxic conditions.Objectives: To evaluate CoCl₂ as a postconditioning therapeutic tool after a myocardial and arterial I/R.Materials and Methods: Isolated adult Wistar rats hearts were arterially perfused at 37ºC by Langendorff method, paced at 3 Hz, exposed to 30 min ischemia followed by 45 min reperfusion (R) in the presence or absence of 0.23 mM CoCl2 which was maintained or removed after 20 min of R.Aortic contractility was evaluated in an isolated organ bath trough incubation with cumulative noradrenaline (NA) doses. After NA washing, 20 min of simulated arterial ischemia (SI) and R with or without CoCl₂ was performed, and NA response was re-evaluated.Results: During R, the presence of CoCl₂ did not alter the cardiac resting pressure, nor the perfusion pressure, but increased the developed pressure (p<0.05) until 20 min which then descend reaching controls values. This decrease was prevented when CoCl₂ was eliminated at 20 min of R. CoCl₂ in R increased the contractile economy (P/Ht) and decreased the cardiac damaged area (p<0.05) and the incidence of arrhythmias (p<0.001).Post-SI arterial contractility increased at the lowest NA dose but not at higher ones. CoCl₂ in post ?SI R did not affect arterial force, but decreased NA sensitivity (EC 50: control: 10-7.5, CoCl2: 10-6.5 M) and the maximum contractile response.Conclusion: The use of CoCl₂ after an ischemic event attenuates the cardiac damage produced at least during the first 25 min of R and reduces the arterial adrenergic contractile response. These results support the use of CoCl₂ as a potential cardioprotective tool of clinical relevance.Fil: Gutierrez, Christopher. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; ArgentinaFil: Farcy, Nicole. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; ArgentinaFil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; ArgentinaFil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; ArgentinaLXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de FisiologíaArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/198974Cobalt chloride protects the heart after a global ischemic insult; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-54CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/reunion-anualNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:34Zoai:ri.conicet.gov.ar:11336/198974instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:34.285CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cobalt chloride protects the heart after a global ischemic insult |
title |
Cobalt chloride protects the heart after a global ischemic insult |
spellingShingle |
Cobalt chloride protects the heart after a global ischemic insult Gutierrez, Christopher POSTCONDICIONAMIENTO CLORURO DE COBALTO CARDIOPROTECCION |
title_short |
Cobalt chloride protects the heart after a global ischemic insult |
title_full |
Cobalt chloride protects the heart after a global ischemic insult |
title_fullStr |
Cobalt chloride protects the heart after a global ischemic insult |
title_full_unstemmed |
Cobalt chloride protects the heart after a global ischemic insult |
title_sort |
Cobalt chloride protects the heart after a global ischemic insult |
dc.creator.none.fl_str_mv |
Gutierrez, Christopher Farcy, Nicole Bonazzola, Patricia Castilla, Rocio Soledad |
author |
Gutierrez, Christopher |
author_facet |
Gutierrez, Christopher Farcy, Nicole Bonazzola, Patricia Castilla, Rocio Soledad |
author_role |
author |
author2 |
Farcy, Nicole Bonazzola, Patricia Castilla, Rocio Soledad |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
POSTCONDICIONAMIENTO CLORURO DE COBALTO CARDIOPROTECCION |
topic |
POSTCONDICIONAMIENTO CLORURO DE COBALTO CARDIOPROTECCION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Ischemia-reperfusion (I/R) is one of the main cardiovascular risk factors and leads to heart contractile and energy dysfunction. I/R-induced damage is reduced by ischemic postconditioning. CoCl₂ has properties to function as a postconditioning agent, since it can trigger transcriptional changes that resemble the response to a hypoxic event under normoxic conditions.Objectives: To evaluate CoCl₂ as a postconditioning therapeutic tool after a myocardial and arterial I/R.Materials and Methods: Isolated adult Wistar rats hearts were arterially perfused at 37ºC by Langendorff method, paced at 3 Hz, exposed to 30 min ischemia followed by 45 min reperfusion (R) in the presence or absence of 0.23 mM CoCl2 which was maintained or removed after 20 min of R.Aortic contractility was evaluated in an isolated organ bath trough incubation with cumulative noradrenaline (NA) doses. After NA washing, 20 min of simulated arterial ischemia (SI) and R with or without CoCl₂ was performed, and NA response was re-evaluated.Results: During R, the presence of CoCl₂ did not alter the cardiac resting pressure, nor the perfusion pressure, but increased the developed pressure (p<0.05) until 20 min which then descend reaching controls values. This decrease was prevented when CoCl₂ was eliminated at 20 min of R. CoCl₂ in R increased the contractile economy (P/Ht) and decreased the cardiac damaged area (p<0.05) and the incidence of arrhythmias (p<0.001).Post-SI arterial contractility increased at the lowest NA dose but not at higher ones. CoCl₂ in post ?SI R did not affect arterial force, but decreased NA sensitivity (EC 50: control: 10-7.5, CoCl2: 10-6.5 M) and the maximum contractile response.Conclusion: The use of CoCl₂ after an ischemic event attenuates the cardiac damage produced at least during the first 25 min of R and reduces the arterial adrenergic contractile response. These results support the use of CoCl₂ as a potential cardioprotective tool of clinical relevance. Fil: Gutierrez, Christopher. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina Fil: Farcy, Nicole. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina Fil: Bonazzola, Patricia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina Fil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional. - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiologicas "prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones En Medicina Traslacional.; Argentina LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología Argentina Sociedad Argentina de Investigación Clínica Sociedad Argentina de Inmunología Sociedad Argentina de Fisiología |
description |
Introduction: Ischemia-reperfusion (I/R) is one of the main cardiovascular risk factors and leads to heart contractile and energy dysfunction. I/R-induced damage is reduced by ischemic postconditioning. CoCl₂ has properties to function as a postconditioning agent, since it can trigger transcriptional changes that resemble the response to a hypoxic event under normoxic conditions.Objectives: To evaluate CoCl₂ as a postconditioning therapeutic tool after a myocardial and arterial I/R.Materials and Methods: Isolated adult Wistar rats hearts were arterially perfused at 37ºC by Langendorff method, paced at 3 Hz, exposed to 30 min ischemia followed by 45 min reperfusion (R) in the presence or absence of 0.23 mM CoCl2 which was maintained or removed after 20 min of R.Aortic contractility was evaluated in an isolated organ bath trough incubation with cumulative noradrenaline (NA) doses. After NA washing, 20 min of simulated arterial ischemia (SI) and R with or without CoCl₂ was performed, and NA response was re-evaluated.Results: During R, the presence of CoCl₂ did not alter the cardiac resting pressure, nor the perfusion pressure, but increased the developed pressure (p<0.05) until 20 min which then descend reaching controls values. This decrease was prevented when CoCl₂ was eliminated at 20 min of R. CoCl₂ in R increased the contractile economy (P/Ht) and decreased the cardiac damaged area (p<0.05) and the incidence of arrhythmias (p<0.001).Post-SI arterial contractility increased at the lowest NA dose but not at higher ones. CoCl₂ in post ?SI R did not affect arterial force, but decreased NA sensitivity (EC 50: control: 10-7.5, CoCl2: 10-6.5 M) and the maximum contractile response.Conclusion: The use of CoCl₂ after an ischemic event attenuates the cardiac damage produced at least during the first 25 min of R and reduces the arterial adrenergic contractile response. These results support the use of CoCl₂ as a potential cardioprotective tool of clinical relevance. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
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http://hdl.handle.net/11336/198974 Cobalt chloride protects the heart after a global ischemic insult; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-54 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/198974 |
identifier_str_mv |
Cobalt chloride protects the heart after a global ischemic insult; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-54 CONICET Digital CONICET |
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eng |
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Fundación Revista Medicina |
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