Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity

Autores
Di Muzio, Laura; Cairone, Francesco; Cesa, Stefania; Sergi, Claudia; Tirillò, Jacopo; Angiolella, Letizia; Giammarino, Andrea; Giusiano, Gustavo Emilio; Petralito, Stefania; Casadei, Maria Antonietta; Paolicelli, Patrizia
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to develop and characterise nanocomposite thin films containing silver nanoparticles (AgNPs), as wound dressings and antifungal materials, using a green process for the nanoparticles’ synthesis and a single step procedure for the preparation of the nanocomposite films. To this end, polyphenol-rich extracts obtained from kiwi peels, an agri-food industrial by-product, were used as a reducing agent of silver nitrate salt. The AgNPs were let form within the film-forming solution, which was composed by low acyl gellan gum and a plasticising agent (glycerol or PEG 400 g/mol) and the corresponding nanocomposite films were deposited by the solvent casting technique. The plasticising agent affected the AgNPs distribution within the films, as observed by SEM and EDS analyses, and consequently their tensile behaviour. In specific, AgNPs act as stress intensifiers in the presence of glycerol, whereas they act as film reinforcement with PEG400. However, both glycerol-plasticised and PEG400-plasticised films exhibited similar antifungal efficacy against 16 clinical isolates of 5 different Candida spp (C. albicans, C. lusitaniae, C. haemulonii, C. krusei and C. glabrata). Globally, the present study provides a green and single-step procedure to develop nanocomposite films embedding AgNPs obtained by in situ reduction of silver ions with polyphenol-rich extracts.
Fil: Di Muzio, Laura. Università degli studi di Roma "La Sapienza"; Italia
Fil: Cairone, Francesco. Università degli studi di Roma "La Sapienza"; Italia
Fil: Cesa, Stefania. Università degli studi di Roma "La Sapienza"; Italia
Fil: Sergi, Claudia. Università degli studi di Roma "La Sapienza"; Italia
Fil: Tirillò, Jacopo. Università degli studi di Roma "La Sapienza"; Italia
Fil: Angiolella, Letizia. Università degli studi di Roma "La Sapienza"; Italia
Fil: Giammarino, Andrea. Università degli studi di Roma "La Sapienza"; Italia
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Petralito, Stefania. Università degli studi di Roma "La Sapienza"; Italia
Fil: Casadei, Maria Antonietta. Università degli studi di Roma "La Sapienza"; Italia
Fil: Paolicelli, Patrizia. Università degli studi di Roma "La Sapienza"; Italia
Materia
Film morphology
Silver nanoparticles
Low acyl gellan gum
Antifungal activity
Candida spp
Kiwi peels extract
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/232100
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/232100
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activityDi Muzio, LauraCairone, FrancescoCesa, StefaniaSergi, ClaudiaTirillò, JacopoAngiolella, LetiziaGiammarino, AndreaGiusiano, Gustavo EmilioPetralito, StefaniaCasadei, Maria AntoniettaPaolicelli, PatriziaFilm morphologySilver nanoparticlesLow acyl gellan gumAntifungal activityCandida sppKiwi peels extracthttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The aim of this work was to develop and characterise nanocomposite thin films containing silver nanoparticles (AgNPs), as wound dressings and antifungal materials, using a green process for the nanoparticles’ synthesis and a single step procedure for the preparation of the nanocomposite films. To this end, polyphenol-rich extracts obtained from kiwi peels, an agri-food industrial by-product, were used as a reducing agent of silver nitrate salt. The AgNPs were let form within the film-forming solution, which was composed by low acyl gellan gum and a plasticising agent (glycerol or PEG 400 g/mol) and the corresponding nanocomposite films were deposited by the solvent casting technique. The plasticising agent affected the AgNPs distribution within the films, as observed by SEM and EDS analyses, and consequently their tensile behaviour. In specific, AgNPs act as stress intensifiers in the presence of glycerol, whereas they act as film reinforcement with PEG400. However, both glycerol-plasticised and PEG400-plasticised films exhibited similar antifungal efficacy against 16 clinical isolates of 5 different Candida spp (C. albicans, C. lusitaniae, C. haemulonii, C. krusei and C. glabrata). Globally, the present study provides a green and single-step procedure to develop nanocomposite films embedding AgNPs obtained by in situ reduction of silver ions with polyphenol-rich extracts.Fil: Di Muzio, Laura. Università degli studi di Roma "La Sapienza"; ItaliaFil: Cairone, Francesco. Università degli studi di Roma "La Sapienza"; ItaliaFil: Cesa, Stefania. Università degli studi di Roma "La Sapienza"; ItaliaFil: Sergi, Claudia. Università degli studi di Roma "La Sapienza"; ItaliaFil: Tirillò, Jacopo. Università degli studi di Roma "La Sapienza"; ItaliaFil: Angiolella, Letizia. Università degli studi di Roma "La Sapienza"; ItaliaFil: Giammarino, Andrea. Università degli studi di Roma "La Sapienza"; ItaliaFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Petralito, Stefania. Università degli studi di Roma "La Sapienza"; ItaliaFil: Casadei, Maria Antonietta. Università degli studi di Roma "La Sapienza"; ItaliaFil: Paolicelli, Patrizia. Università degli studi di Roma "La Sapienza"; ItaliaElsevier2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/232100Di Muzio, Laura; Cairone, Francesco; Cesa, Stefania; Sergi, Claudia; Tirillò, Jacopo; et al.; Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity; Elsevier; Carbohydrate Polymer Technologies and Applications; 7; 100485; 6-2024; 1-122666-8939CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.carpta.2024.100485info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2666893924000653info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:49Zoai:ri.conicet.gov.ar:11336/232100instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:49.782CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
title Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
spellingShingle Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
Di Muzio, Laura
Film morphology
Silver nanoparticles
Low acyl gellan gum
Antifungal activity
Candida spp
Kiwi peels extract
title_short Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
title_full Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
title_fullStr Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
title_full_unstemmed Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
title_sort Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity
dc.creator.none.fl_str_mv Di Muzio, Laura
Cairone, Francesco
Cesa, Stefania
Sergi, Claudia
Tirillò, Jacopo
Angiolella, Letizia
Giammarino, Andrea
Giusiano, Gustavo Emilio
Petralito, Stefania
Casadei, Maria Antonietta
Paolicelli, Patrizia
author Di Muzio, Laura
author_facet Di Muzio, Laura
Cairone, Francesco
Cesa, Stefania
Sergi, Claudia
Tirillò, Jacopo
Angiolella, Letizia
Giammarino, Andrea
Giusiano, Gustavo Emilio
Petralito, Stefania
Casadei, Maria Antonietta
Paolicelli, Patrizia
author_role author
author2 Cairone, Francesco
Cesa, Stefania
Sergi, Claudia
Tirillò, Jacopo
Angiolella, Letizia
Giammarino, Andrea
Giusiano, Gustavo Emilio
Petralito, Stefania
Casadei, Maria Antonietta
Paolicelli, Patrizia
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Film morphology
Silver nanoparticles
Low acyl gellan gum
Antifungal activity
Candida spp
Kiwi peels extract
topic Film morphology
Silver nanoparticles
Low acyl gellan gum
Antifungal activity
Candida spp
Kiwi peels extract
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this work was to develop and characterise nanocomposite thin films containing silver nanoparticles (AgNPs), as wound dressings and antifungal materials, using a green process for the nanoparticles’ synthesis and a single step procedure for the preparation of the nanocomposite films. To this end, polyphenol-rich extracts obtained from kiwi peels, an agri-food industrial by-product, were used as a reducing agent of silver nitrate salt. The AgNPs were let form within the film-forming solution, which was composed by low acyl gellan gum and a plasticising agent (glycerol or PEG 400 g/mol) and the corresponding nanocomposite films were deposited by the solvent casting technique. The plasticising agent affected the AgNPs distribution within the films, as observed by SEM and EDS analyses, and consequently their tensile behaviour. In specific, AgNPs act as stress intensifiers in the presence of glycerol, whereas they act as film reinforcement with PEG400. However, both glycerol-plasticised and PEG400-plasticised films exhibited similar antifungal efficacy against 16 clinical isolates of 5 different Candida spp (C. albicans, C. lusitaniae, C. haemulonii, C. krusei and C. glabrata). Globally, the present study provides a green and single-step procedure to develop nanocomposite films embedding AgNPs obtained by in situ reduction of silver ions with polyphenol-rich extracts.
Fil: Di Muzio, Laura. Università degli studi di Roma "La Sapienza"; Italia
Fil: Cairone, Francesco. Università degli studi di Roma "La Sapienza"; Italia
Fil: Cesa, Stefania. Università degli studi di Roma "La Sapienza"; Italia
Fil: Sergi, Claudia. Università degli studi di Roma "La Sapienza"; Italia
Fil: Tirillò, Jacopo. Università degli studi di Roma "La Sapienza"; Italia
Fil: Angiolella, Letizia. Università degli studi di Roma "La Sapienza"; Italia
Fil: Giammarino, Andrea. Università degli studi di Roma "La Sapienza"; Italia
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Petralito, Stefania. Università degli studi di Roma "La Sapienza"; Italia
Fil: Casadei, Maria Antonietta. Università degli studi di Roma "La Sapienza"; Italia
Fil: Paolicelli, Patrizia. Università degli studi di Roma "La Sapienza"; Italia
description The aim of this work was to develop and characterise nanocomposite thin films containing silver nanoparticles (AgNPs), as wound dressings and antifungal materials, using a green process for the nanoparticles’ synthesis and a single step procedure for the preparation of the nanocomposite films. To this end, polyphenol-rich extracts obtained from kiwi peels, an agri-food industrial by-product, were used as a reducing agent of silver nitrate salt. The AgNPs were let form within the film-forming solution, which was composed by low acyl gellan gum and a plasticising agent (glycerol or PEG 400 g/mol) and the corresponding nanocomposite films were deposited by the solvent casting technique. The plasticising agent affected the AgNPs distribution within the films, as observed by SEM and EDS analyses, and consequently their tensile behaviour. In specific, AgNPs act as stress intensifiers in the presence of glycerol, whereas they act as film reinforcement with PEG400. However, both glycerol-plasticised and PEG400-plasticised films exhibited similar antifungal efficacy against 16 clinical isolates of 5 different Candida spp (C. albicans, C. lusitaniae, C. haemulonii, C. krusei and C. glabrata). Globally, the present study provides a green and single-step procedure to develop nanocomposite films embedding AgNPs obtained by in situ reduction of silver ions with polyphenol-rich extracts.
publishDate 2024
dc.date.none.fl_str_mv 2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/232100
Di Muzio, Laura; Cairone, Francesco; Cesa, Stefania; Sergi, Claudia; Tirillò, Jacopo; et al.; Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity; Elsevier; Carbohydrate Polymer Technologies and Applications; 7; 100485; 6-2024; 1-12
2666-8939
CONICET Digital
CONICET
url http://hdl.handle.net/11336/232100
identifier_str_mv Di Muzio, Laura; Cairone, Francesco; Cesa, Stefania; Sergi, Claudia; Tirillò, Jacopo; et al.; Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles: Synthesis, characterisation and antifungal activity; Elsevier; Carbohydrate Polymer Technologies and Applications; 7; 100485; 6-2024; 1-12
2666-8939
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carpta.2024.100485
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2666893924000653
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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