Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile

Autores
Diaz, Maria del Pilar; Icaza, Gloria; Nuñez, Loreto; Pou, Sonia Alejandra
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although Argentina and Chile are neighboring countries, gastric cancer (GC) is the first cancer death cause in the Chilean male population, while it is ranked in fifth place for Argentinean males. This study is the first to identify the differential time-patterns associated with the age-period-cohort effects for the last few decades (1990–2015) in these Southern Cone countries. Trends of age-standardized truncated mortality rates (ASMR) for GC were analyzed using log-linear Poisson age-period-cohort models, including cubic splines for each component. The ASMR trends for GC decreased in both sexes but more considerably in Chile and more favorably for males (annual percentage changes 2002–2015 = −3.5, 95%CI: −3.9 to −3.1). Moreover, GC age-specific mortality rates were noticeably higher in Chile. A favorable decreasing mortality risk throughout the periods (from 2000) and by cohort was observed for both countries; however, the risk reduction has stabilized in younger female cohorts since 1950-cohort. In conclusion, overall favorable decreasing trends for GC mortality were found; however, when age-period-cohort effects were disentangled, Chile and younger female cohorts showed a more unfavorable scenario. Obesity, lifestyles, and environmental conditions (like altitude) may explain country differences. This analytical approach may be a valuable tool to be replicated in other countries with no population-based cancer registries and acceptable mortality data quality.
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Icaza, Gloria. Universidad de Talca; Chile. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); Chile
Fil: Nuñez, Loreto. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); Chile. Universidad de Talca; Chile
Fil: Pou, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Materia
STOMACH NEOPLASMS
AGE-PERIOD-COHORT MODELS
ARGENTINA
CHILE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140518
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/140518
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and ChileDiaz, Maria del PilarIcaza, GloriaNuñez, LoretoPou, Sonia AlejandraSTOMACH NEOPLASMSAGE-PERIOD-COHORT MODELSARGENTINACHILEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Although Argentina and Chile are neighboring countries, gastric cancer (GC) is the first cancer death cause in the Chilean male population, while it is ranked in fifth place for Argentinean males. This study is the first to identify the differential time-patterns associated with the age-period-cohort effects for the last few decades (1990–2015) in these Southern Cone countries. Trends of age-standardized truncated mortality rates (ASMR) for GC were analyzed using log-linear Poisson age-period-cohort models, including cubic splines for each component. The ASMR trends for GC decreased in both sexes but more considerably in Chile and more favorably for males (annual percentage changes 2002–2015 = −3.5, 95%CI: −3.9 to −3.1). Moreover, GC age-specific mortality rates were noticeably higher in Chile. A favorable decreasing mortality risk throughout the periods (from 2000) and by cohort was observed for both countries; however, the risk reduction has stabilized in younger female cohorts since 1950-cohort. In conclusion, overall favorable decreasing trends for GC mortality were found; however, when age-period-cohort effects were disentangled, Chile and younger female cohorts showed a more unfavorable scenario. Obesity, lifestyles, and environmental conditions (like altitude) may explain country differences. This analytical approach may be a valuable tool to be replicated in other countries with no population-based cancer registries and acceptable mortality data quality.Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Icaza, Gloria. Universidad de Talca; Chile. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); ChileFil: Nuñez, Loreto. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); Chile. Universidad de Talca; ChileFil: Pou, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaNature Research2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140518Diaz, Maria del Pilar; Icaza, Gloria; Nuñez, Loreto; Pou, Sonia Alejandra; Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-82045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-58539-winfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-58539-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:14:28Zoai:ri.conicet.gov.ar:11336/140518instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:14:28.884CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
title Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
spellingShingle Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
Diaz, Maria del Pilar
STOMACH NEOPLASMS
AGE-PERIOD-COHORT MODELS
ARGENTINA
CHILE
title_short Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
title_full Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
title_fullStr Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
title_full_unstemmed Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
title_sort Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile
dc.creator.none.fl_str_mv Diaz, Maria del Pilar
Icaza, Gloria
Nuñez, Loreto
Pou, Sonia Alejandra
author Diaz, Maria del Pilar
author_facet Diaz, Maria del Pilar
Icaza, Gloria
Nuñez, Loreto
Pou, Sonia Alejandra
author_role author
author2 Icaza, Gloria
Nuñez, Loreto
Pou, Sonia Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv STOMACH NEOPLASMS
AGE-PERIOD-COHORT MODELS
ARGENTINA
CHILE
topic STOMACH NEOPLASMS
AGE-PERIOD-COHORT MODELS
ARGENTINA
CHILE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although Argentina and Chile are neighboring countries, gastric cancer (GC) is the first cancer death cause in the Chilean male population, while it is ranked in fifth place for Argentinean males. This study is the first to identify the differential time-patterns associated with the age-period-cohort effects for the last few decades (1990–2015) in these Southern Cone countries. Trends of age-standardized truncated mortality rates (ASMR) for GC were analyzed using log-linear Poisson age-period-cohort models, including cubic splines for each component. The ASMR trends for GC decreased in both sexes but more considerably in Chile and more favorably for males (annual percentage changes 2002–2015 = −3.5, 95%CI: −3.9 to −3.1). Moreover, GC age-specific mortality rates were noticeably higher in Chile. A favorable decreasing mortality risk throughout the periods (from 2000) and by cohort was observed for both countries; however, the risk reduction has stabilized in younger female cohorts since 1950-cohort. In conclusion, overall favorable decreasing trends for GC mortality were found; however, when age-period-cohort effects were disentangled, Chile and younger female cohorts showed a more unfavorable scenario. Obesity, lifestyles, and environmental conditions (like altitude) may explain country differences. This analytical approach may be a valuable tool to be replicated in other countries with no population-based cancer registries and acceptable mortality data quality.
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Icaza, Gloria. Universidad de Talca; Chile. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); Chile
Fil: Nuñez, Loreto. Programa de Investigación Asociativa En Cáncer Gástrico (pia-cg); Chile. Universidad de Talca; Chile
Fil: Pou, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
description Although Argentina and Chile are neighboring countries, gastric cancer (GC) is the first cancer death cause in the Chilean male population, while it is ranked in fifth place for Argentinean males. This study is the first to identify the differential time-patterns associated with the age-period-cohort effects for the last few decades (1990–2015) in these Southern Cone countries. Trends of age-standardized truncated mortality rates (ASMR) for GC were analyzed using log-linear Poisson age-period-cohort models, including cubic splines for each component. The ASMR trends for GC decreased in both sexes but more considerably in Chile and more favorably for males (annual percentage changes 2002–2015 = −3.5, 95%CI: −3.9 to −3.1). Moreover, GC age-specific mortality rates were noticeably higher in Chile. A favorable decreasing mortality risk throughout the periods (from 2000) and by cohort was observed for both countries; however, the risk reduction has stabilized in younger female cohorts since 1950-cohort. In conclusion, overall favorable decreasing trends for GC mortality were found; however, when age-period-cohort effects were disentangled, Chile and younger female cohorts showed a more unfavorable scenario. Obesity, lifestyles, and environmental conditions (like altitude) may explain country differences. This analytical approach may be a valuable tool to be replicated in other countries with no population-based cancer registries and acceptable mortality data quality.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140518
Diaz, Maria del Pilar; Icaza, Gloria; Nuñez, Loreto; Pou, Sonia Alejandra; Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140518
identifier_str_mv Diaz, Maria del Pilar; Icaza, Gloria; Nuñez, Loreto; Pou, Sonia Alejandra; Gastric cancer mortality Trends in the southern cone: Disentangling age, period and cohort patterns in Argentina and Chile; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-58539-w
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-58539-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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