Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis

Autores
Pou, Sonia Alejandra; Osella, Alberto Rubén; Eynard, Aldo Renato; Diaz, Maria del Pilar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims and background. Cancer is the second main cause of death in Argentina, surpassed only by cardiovascular disease. However, analytical approaches isolating some of the known effects, such as age at death, period of death and birth cohort, have never been performed in cancer mortality studies in Argentina. The aim of this study was to analyze cancer mortality trends in a representative region of the country, the Córdoba province (1986-2006). Methods and study design. Overall age-standardized (world population) mortality rates for cancer (all sites) were computed by a direct method. Joinpoint regression was fitted to the age-standardized mortality rates for both sexes to provide estimated and 95% confidence intervals of the annual percentage changes. The effects of age (15 age groups), period of death (1986-90, 1991-95, 1996-00 or 2001-06), and birth cohort (18 overlapping 10-year birth cohorts) covariates on mortality rates were estimated using a sequentially fitted Poisson regression model. Results. During the study period, 102,737 people died of cancer in Córdoba, with the age-standardized mortality rates decreasing from 139.3 to 118.7/100,000 personyears. Although this reduction was more noticeable in men, the joinpoint regression model showed a significant change of the age-standardized mortality rates after 1996 in both sexes. Age-period-cohort analysis suggested that the cancer mortality trends may be linked with a strong age effect and a moderate or mild period and cohort effect, related to sex and place of residence. Conclusions.Based on the observed cohort effect, it may be argued that there has been a lower exposure level to some risk factors, such as diet and other environmental factors, in Cordoba over the last decades. Free full text available at www.tumorionline.it
Fil: Pou, Sonia Alejandra. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Osella, Alberto Rubén. Istituto Nazionale Di Ricovero E Cura A Carattere Scientifico "saverio de Bellis". Laboratorio Di Epidemiologia E Biostatistica.; Italia
Fil: Eynard, Aldo Renato. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Biología Celular; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición. Cátedra de Estadística y Bioestadística; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
AGE-PERIOD-COHORT MODEL
ARGENTINA
CANCER MORTALITY
CORDOBA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130487
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort AnalysisPou, Sonia AlejandraOsella, Alberto RubénEynard, Aldo RenatoDiaz, Maria del PilarAGE-PERIOD-COHORT MODELARGENTINACANCER MORTALITYCORDOBAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aims and background. Cancer is the second main cause of death in Argentina, surpassed only by cardiovascular disease. However, analytical approaches isolating some of the known effects, such as age at death, period of death and birth cohort, have never been performed in cancer mortality studies in Argentina. The aim of this study was to analyze cancer mortality trends in a representative region of the country, the Córdoba province (1986-2006). Methods and study design. Overall age-standardized (world population) mortality rates for cancer (all sites) were computed by a direct method. Joinpoint regression was fitted to the age-standardized mortality rates for both sexes to provide estimated and 95% confidence intervals of the annual percentage changes. The effects of age (15 age groups), period of death (1986-90, 1991-95, 1996-00 or 2001-06), and birth cohort (18 overlapping 10-year birth cohorts) covariates on mortality rates were estimated using a sequentially fitted Poisson regression model. Results. During the study period, 102,737 people died of cancer in Córdoba, with the age-standardized mortality rates decreasing from 139.3 to 118.7/100,000 personyears. Although this reduction was more noticeable in men, the joinpoint regression model showed a significant change of the age-standardized mortality rates after 1996 in both sexes. Age-period-cohort analysis suggested that the cancer mortality trends may be linked with a strong age effect and a moderate or mild period and cohort effect, related to sex and place of residence. Conclusions.Based on the observed cohort effect, it may be argued that there has been a lower exposure level to some risk factors, such as diet and other environmental factors, in Cordoba over the last decades. Free full text available at www.tumorionline.itFil: Pou, Sonia Alejandra. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Osella, Alberto Rubén. Istituto Nazionale Di Ricovero E Cura A Carattere Scientifico "saverio de Bellis". Laboratorio Di Epidemiologia E Biostatistica.; ItaliaFil: Eynard, Aldo Renato. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Biología Celular; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición. Cátedra de Estadística y Bioestadística; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaPensiero Scientifico Editor2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130487Pou, Sonia Alejandra; Osella, Alberto Rubén; Eynard, Aldo Renato; Diaz, Maria del Pilar; Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis; Pensiero Scientifico Editor; Tumori; 96; 2; 1-2018; 202-2120300-8916CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/030089161009600204info:eu-repo/semantics/altIdentifier/doi/10.1177%2F030089161009600204info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:12Zoai:ri.conicet.gov.ar:11336/130487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:12.687CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
title Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
spellingShingle Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
Pou, Sonia Alejandra
AGE-PERIOD-COHORT MODEL
ARGENTINA
CANCER MORTALITY
CORDOBA
title_short Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
title_full Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
title_fullStr Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
title_full_unstemmed Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
title_sort Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis
dc.creator.none.fl_str_mv Pou, Sonia Alejandra
Osella, Alberto Rubén
Eynard, Aldo Renato
Diaz, Maria del Pilar
author Pou, Sonia Alejandra
author_facet Pou, Sonia Alejandra
Osella, Alberto Rubén
Eynard, Aldo Renato
Diaz, Maria del Pilar
author_role author
author2 Osella, Alberto Rubén
Eynard, Aldo Renato
Diaz, Maria del Pilar
author2_role author
author
author
dc.subject.none.fl_str_mv AGE-PERIOD-COHORT MODEL
ARGENTINA
CANCER MORTALITY
CORDOBA
topic AGE-PERIOD-COHORT MODEL
ARGENTINA
CANCER MORTALITY
CORDOBA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims and background. Cancer is the second main cause of death in Argentina, surpassed only by cardiovascular disease. However, analytical approaches isolating some of the known effects, such as age at death, period of death and birth cohort, have never been performed in cancer mortality studies in Argentina. The aim of this study was to analyze cancer mortality trends in a representative region of the country, the Córdoba province (1986-2006). Methods and study design. Overall age-standardized (world population) mortality rates for cancer (all sites) were computed by a direct method. Joinpoint regression was fitted to the age-standardized mortality rates for both sexes to provide estimated and 95% confidence intervals of the annual percentage changes. The effects of age (15 age groups), period of death (1986-90, 1991-95, 1996-00 or 2001-06), and birth cohort (18 overlapping 10-year birth cohorts) covariates on mortality rates were estimated using a sequentially fitted Poisson regression model. Results. During the study period, 102,737 people died of cancer in Córdoba, with the age-standardized mortality rates decreasing from 139.3 to 118.7/100,000 personyears. Although this reduction was more noticeable in men, the joinpoint regression model showed a significant change of the age-standardized mortality rates after 1996 in both sexes. Age-period-cohort analysis suggested that the cancer mortality trends may be linked with a strong age effect and a moderate or mild period and cohort effect, related to sex and place of residence. Conclusions.Based on the observed cohort effect, it may be argued that there has been a lower exposure level to some risk factors, such as diet and other environmental factors, in Cordoba over the last decades. Free full text available at www.tumorionline.it
Fil: Pou, Sonia Alejandra. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Osella, Alberto Rubén. Istituto Nazionale Di Ricovero E Cura A Carattere Scientifico "saverio de Bellis". Laboratorio Di Epidemiologia E Biostatistica.; Italia
Fil: Eynard, Aldo Renato. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Biología Celular; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición. Cátedra de Estadística y Bioestadística; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Aims and background. Cancer is the second main cause of death in Argentina, surpassed only by cardiovascular disease. However, analytical approaches isolating some of the known effects, such as age at death, period of death and birth cohort, have never been performed in cancer mortality studies in Argentina. The aim of this study was to analyze cancer mortality trends in a representative region of the country, the Córdoba province (1986-2006). Methods and study design. Overall age-standardized (world population) mortality rates for cancer (all sites) were computed by a direct method. Joinpoint regression was fitted to the age-standardized mortality rates for both sexes to provide estimated and 95% confidence intervals of the annual percentage changes. The effects of age (15 age groups), period of death (1986-90, 1991-95, 1996-00 or 2001-06), and birth cohort (18 overlapping 10-year birth cohorts) covariates on mortality rates were estimated using a sequentially fitted Poisson regression model. Results. During the study period, 102,737 people died of cancer in Córdoba, with the age-standardized mortality rates decreasing from 139.3 to 118.7/100,000 personyears. Although this reduction was more noticeable in men, the joinpoint regression model showed a significant change of the age-standardized mortality rates after 1996 in both sexes. Age-period-cohort analysis suggested that the cancer mortality trends may be linked with a strong age effect and a moderate or mild period and cohort effect, related to sex and place of residence. Conclusions.Based on the observed cohort effect, it may be argued that there has been a lower exposure level to some risk factors, such as diet and other environmental factors, in Cordoba over the last decades. Free full text available at www.tumorionline.it
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130487
Pou, Sonia Alejandra; Osella, Alberto Rubén; Eynard, Aldo Renato; Diaz, Maria del Pilar; Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis; Pensiero Scientifico Editor; Tumori; 96; 2; 1-2018; 202-212
0300-8916
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130487
identifier_str_mv Pou, Sonia Alejandra; Osella, Alberto Rubén; Eynard, Aldo Renato; Diaz, Maria del Pilar; Cancer Mortality in Córdoba, Argentina, 1986–2006: An Age-Period-Cohort Analysis; Pensiero Scientifico Editor; Tumori; 96; 2; 1-2018; 202-212
0300-8916
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/030089161009600204
info:eu-repo/semantics/altIdentifier/doi/10.1177%2F030089161009600204
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pensiero Scientifico Editor
publisher.none.fl_str_mv Pensiero Scientifico Editor
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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