Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer

Autores
Sahasrabudhe, Ruta; Lott, Paul; Bohorquez, Mabel; Toal, Ted; Estrada, Ana P.; Suarez, John J.; Brea Fernández, Alejandro; Cameselle Teijeiro, José; Pinto, Carla; Ramos, Irma; Mantilla, Alejandra; Prieto, Rodrigo; Corvalan, Alejandro; Norero, Enrique; Alvarez, Carolina; Tapia, Teresa; Carvallo, Pilar; Gonzalez, Luz M.; Cock-Rada, Alicia; Solano, Angela Rosario; Neffa, Florencia; Della Valle, Adriana; Yau, Chris; Soares, Gabriela; Borowsky, Alexander; Hu, Nan; He, Li-Ji; Han, Xiao-You; Taylor, Philip R.; Goldstein, Alisa M.; Torres, Javier; Echeverry, Magdalena; Ruiz-Ponte, Clara; Teixeira, Manuel R.; Carvajal Carmona, Luis G.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination. We found these mutations in 2 of 31 patients with HDGC (6.5%) and 9 of 331 patients with sporadic gastric cancer (2.8%). Most of these mutations had been previously associated with other types of tumors and partially co-segregated with gastric cancer in our study. Tumors that developed in patients with these mutations had a mutation signature associated with somatic homologous recombination deficiency. Our findings indicate that defects in homologous recombination increase risk for gastric cancer.
Fil: Sahasrabudhe, Ruta. University of California at Davis; Estados Unidos
Fil: Lott, Paul. University of California at Davis; Estados Unidos
Fil: Bohorquez, Mabel. Universidad del Tolima; Colombia
Fil: Toal, Ted. University of California at Davis; Estados Unidos
Fil: Estrada, Ana P.. Universidad del Tolima; Colombia
Fil: Suarez, John J.. Universidad del Tolima; Colombia
Fil: Brea Fernández, Alejandro. Ciber Enfermedades Raras; España
Fil: Cameselle Teijeiro, José. Complejo Hospitalario Universitario de Santiago; España
Fil: Pinto, Carla. Instituto Portugues de Oncologia de Francisco Gentil Porto; Portugal
Fil: Ramos, Irma. Instituto Mexicano del Seguro Social; México
Fil: Mantilla, Alejandra. Departamento de Patologia la Unidad Medica Alta Especialidad Oncologia; México
Fil: Prieto, Rodrigo. Universidad del Tolima; Colombia
Fil: Corvalan, Alejandro. Pontificia Universidad Católica de Chile; Chile
Fil: Norero, Enrique. Pontificia Universidad Católica de Chile; Chile
Fil: Alvarez, Carolina. Universidad Católica de Chile; Chile
Fil: Tapia, Teresa. Pontificia Universidad Católica de Chile; Chile
Fil: Carvallo, Pilar. Pontificia Universidad Católica de Chile; Chile
Fil: Gonzalez, Luz M.. Instituto de Cancerologia, Las Americas; Colombia
Fil: Cock-Rada, Alicia. Instituto de Cancerologia, Las Americas; Colombia
Fil: Solano, Angela Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Universidad de Buenos Aires; Argentina
Fil: Neffa, Florencia. Laboratorio Genia; Uruguay
Fil: Della Valle, Adriana. Laboratorio Genia; Uruguay
Fil: Yau, Chris. University of Oxford; Reino Unido
Fil: Soares, Gabriela. Centro Hospitalar Do Porto; Portugal
Fil: Borowsky, Alexander. University of California at Davis; Estados Unidos
Fil: Hu, Nan. National Cancer Institute; Estados Unidos
Fil: He, Li-Ji. Yangcheng Cancer Hospital; China
Fil: Han, Xiao-You. Shanxi Cancer Hospital; China
Fil: Taylor, Philip R.. National Institutes of Health; Estados Unidos
Fil: Goldstein, Alisa M.. National Institutes of Health; Estados Unidos
Fil: Torres, Javier. Instituto Mexicano del Seguro Social; México
Fil: Echeverry, Magdalena. Universidad del Tolima; Colombia
Fil: Ruiz-Ponte, Clara. Centro de Investigación Biomédica en Red de Enfermedades Raras; España
Fil: Teixeira, Manuel R.. Universidad de Porto; Portugal
Fil: Carvajal Carmona, Luis G.. University of California at Davis; Estados Unidos
Materia
Interaction
Stomach
Tumor
Wes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41447

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric CancerSahasrabudhe, RutaLott, PaulBohorquez, MabelToal, TedEstrada, Ana P.Suarez, John J.Brea Fernández, AlejandroCameselle Teijeiro, JoséPinto, CarlaRamos, IrmaMantilla, AlejandraPrieto, RodrigoCorvalan, AlejandroNorero, EnriqueAlvarez, CarolinaTapia, TeresaCarvallo, PilarGonzalez, Luz M.Cock-Rada, AliciaSolano, Angela RosarioNeffa, FlorenciaDella Valle, AdrianaYau, ChrisSoares, GabrielaBorowsky, AlexanderHu, NanHe, Li-JiHan, Xiao-YouTaylor, Philip R.Goldstein, Alisa M.Torres, JavierEcheverry, MagdalenaRuiz-Ponte, ClaraTeixeira, Manuel R.Carvajal Carmona, Luis G.InteractionStomachTumorWeshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination. We found these mutations in 2 of 31 patients with HDGC (6.5%) and 9 of 331 patients with sporadic gastric cancer (2.8%). Most of these mutations had been previously associated with other types of tumors and partially co-segregated with gastric cancer in our study. Tumors that developed in patients with these mutations had a mutation signature associated with somatic homologous recombination deficiency. Our findings indicate that defects in homologous recombination increase risk for gastric cancer.Fil: Sahasrabudhe, Ruta. University of California at Davis; Estados UnidosFil: Lott, Paul. University of California at Davis; Estados UnidosFil: Bohorquez, Mabel. Universidad del Tolima; ColombiaFil: Toal, Ted. University of California at Davis; Estados UnidosFil: Estrada, Ana P.. Universidad del Tolima; ColombiaFil: Suarez, John J.. Universidad del Tolima; ColombiaFil: Brea Fernández, Alejandro. Ciber Enfermedades Raras; EspañaFil: Cameselle Teijeiro, José. Complejo Hospitalario Universitario de Santiago; EspañaFil: Pinto, Carla. Instituto Portugues de Oncologia de Francisco Gentil Porto; PortugalFil: Ramos, Irma. Instituto Mexicano del Seguro Social; MéxicoFil: Mantilla, Alejandra. Departamento de Patologia la Unidad Medica Alta Especialidad Oncologia; MéxicoFil: Prieto, Rodrigo. Universidad del Tolima; ColombiaFil: Corvalan, Alejandro. Pontificia Universidad Católica de Chile; ChileFil: Norero, Enrique. Pontificia Universidad Católica de Chile; ChileFil: Alvarez, Carolina. Universidad Católica de Chile; ChileFil: Tapia, Teresa. Pontificia Universidad Católica de Chile; ChileFil: Carvallo, Pilar. Pontificia Universidad Católica de Chile; ChileFil: Gonzalez, Luz M.. Instituto de Cancerologia, Las Americas; ColombiaFil: Cock-Rada, Alicia. Instituto de Cancerologia, Las Americas; ColombiaFil: Solano, Angela Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Universidad de Buenos Aires; ArgentinaFil: Neffa, Florencia. Laboratorio Genia; UruguayFil: Della Valle, Adriana. Laboratorio Genia; UruguayFil: Yau, Chris. University of Oxford; Reino UnidoFil: Soares, Gabriela. Centro Hospitalar Do Porto; PortugalFil: Borowsky, Alexander. University of California at Davis; Estados UnidosFil: Hu, Nan. National Cancer Institute; Estados UnidosFil: He, Li-Ji. Yangcheng Cancer Hospital; ChinaFil: Han, Xiao-You. Shanxi Cancer Hospital; ChinaFil: Taylor, Philip R.. National Institutes of Health; Estados UnidosFil: Goldstein, Alisa M.. National Institutes of Health; Estados UnidosFil: Torres, Javier. Instituto Mexicano del Seguro Social; MéxicoFil: Echeverry, Magdalena. Universidad del Tolima; ColombiaFil: Ruiz-Ponte, Clara. Centro de Investigación Biomédica en Red de Enfermedades Raras; EspañaFil: Teixeira, Manuel R.. Universidad de Porto; PortugalFil: Carvajal Carmona, Luis G.. University of California at Davis; Estados UnidosW B Saunders Co-Elsevier Inc2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41447Sahasrabudhe, Ruta; Lott, Paul; Bohorquez, Mabel; Toal, Ted; Estrada, Ana P.; et al.; Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer; W B Saunders Co-Elsevier Inc; Gastroenterology; 152; 5; 4-2017; 983-9860016-5085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1053/j.gastro.2016.12.010info:eu-repo/semantics/altIdentifier/url/http://www.gastrojournal.org/article/S0016-5085(16)35521-4/fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:05Zoai:ri.conicet.gov.ar:11336/41447instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:05.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
title Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
spellingShingle Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
Sahasrabudhe, Ruta
Interaction
Stomach
Tumor
Wes
title_short Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
title_full Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
title_fullStr Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
title_full_unstemmed Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
title_sort Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
dc.creator.none.fl_str_mv Sahasrabudhe, Ruta
Lott, Paul
Bohorquez, Mabel
Toal, Ted
Estrada, Ana P.
Suarez, John J.
Brea Fernández, Alejandro
Cameselle Teijeiro, José
Pinto, Carla
Ramos, Irma
Mantilla, Alejandra
Prieto, Rodrigo
Corvalan, Alejandro
Norero, Enrique
Alvarez, Carolina
Tapia, Teresa
Carvallo, Pilar
Gonzalez, Luz M.
Cock-Rada, Alicia
Solano, Angela Rosario
Neffa, Florencia
Della Valle, Adriana
Yau, Chris
Soares, Gabriela
Borowsky, Alexander
Hu, Nan
He, Li-Ji
Han, Xiao-You
Taylor, Philip R.
Goldstein, Alisa M.
Torres, Javier
Echeverry, Magdalena
Ruiz-Ponte, Clara
Teixeira, Manuel R.
Carvajal Carmona, Luis G.
author Sahasrabudhe, Ruta
author_facet Sahasrabudhe, Ruta
Lott, Paul
Bohorquez, Mabel
Toal, Ted
Estrada, Ana P.
Suarez, John J.
Brea Fernández, Alejandro
Cameselle Teijeiro, José
Pinto, Carla
Ramos, Irma
Mantilla, Alejandra
Prieto, Rodrigo
Corvalan, Alejandro
Norero, Enrique
Alvarez, Carolina
Tapia, Teresa
Carvallo, Pilar
Gonzalez, Luz M.
Cock-Rada, Alicia
Solano, Angela Rosario
Neffa, Florencia
Della Valle, Adriana
Yau, Chris
Soares, Gabriela
Borowsky, Alexander
Hu, Nan
He, Li-Ji
Han, Xiao-You
Taylor, Philip R.
Goldstein, Alisa M.
Torres, Javier
Echeverry, Magdalena
Ruiz-Ponte, Clara
Teixeira, Manuel R.
Carvajal Carmona, Luis G.
author_role author
author2 Lott, Paul
Bohorquez, Mabel
Toal, Ted
Estrada, Ana P.
Suarez, John J.
Brea Fernández, Alejandro
Cameselle Teijeiro, José
Pinto, Carla
Ramos, Irma
Mantilla, Alejandra
Prieto, Rodrigo
Corvalan, Alejandro
Norero, Enrique
Alvarez, Carolina
Tapia, Teresa
Carvallo, Pilar
Gonzalez, Luz M.
Cock-Rada, Alicia
Solano, Angela Rosario
Neffa, Florencia
Della Valle, Adriana
Yau, Chris
Soares, Gabriela
Borowsky, Alexander
Hu, Nan
He, Li-Ji
Han, Xiao-You
Taylor, Philip R.
Goldstein, Alisa M.
Torres, Javier
Echeverry, Magdalena
Ruiz-Ponte, Clara
Teixeira, Manuel R.
Carvajal Carmona, Luis G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Interaction
Stomach
Tumor
Wes
topic Interaction
Stomach
Tumor
Wes
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination. We found these mutations in 2 of 31 patients with HDGC (6.5%) and 9 of 331 patients with sporadic gastric cancer (2.8%). Most of these mutations had been previously associated with other types of tumors and partially co-segregated with gastric cancer in our study. Tumors that developed in patients with these mutations had a mutation signature associated with somatic homologous recombination deficiency. Our findings indicate that defects in homologous recombination increase risk for gastric cancer.
Fil: Sahasrabudhe, Ruta. University of California at Davis; Estados Unidos
Fil: Lott, Paul. University of California at Davis; Estados Unidos
Fil: Bohorquez, Mabel. Universidad del Tolima; Colombia
Fil: Toal, Ted. University of California at Davis; Estados Unidos
Fil: Estrada, Ana P.. Universidad del Tolima; Colombia
Fil: Suarez, John J.. Universidad del Tolima; Colombia
Fil: Brea Fernández, Alejandro. Ciber Enfermedades Raras; España
Fil: Cameselle Teijeiro, José. Complejo Hospitalario Universitario de Santiago; España
Fil: Pinto, Carla. Instituto Portugues de Oncologia de Francisco Gentil Porto; Portugal
Fil: Ramos, Irma. Instituto Mexicano del Seguro Social; México
Fil: Mantilla, Alejandra. Departamento de Patologia la Unidad Medica Alta Especialidad Oncologia; México
Fil: Prieto, Rodrigo. Universidad del Tolima; Colombia
Fil: Corvalan, Alejandro. Pontificia Universidad Católica de Chile; Chile
Fil: Norero, Enrique. Pontificia Universidad Católica de Chile; Chile
Fil: Alvarez, Carolina. Universidad Católica de Chile; Chile
Fil: Tapia, Teresa. Pontificia Universidad Católica de Chile; Chile
Fil: Carvallo, Pilar. Pontificia Universidad Católica de Chile; Chile
Fil: Gonzalez, Luz M.. Instituto de Cancerologia, Las Americas; Colombia
Fil: Cock-Rada, Alicia. Instituto de Cancerologia, Las Americas; Colombia
Fil: Solano, Angela Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Universidad de Buenos Aires; Argentina
Fil: Neffa, Florencia. Laboratorio Genia; Uruguay
Fil: Della Valle, Adriana. Laboratorio Genia; Uruguay
Fil: Yau, Chris. University of Oxford; Reino Unido
Fil: Soares, Gabriela. Centro Hospitalar Do Porto; Portugal
Fil: Borowsky, Alexander. University of California at Davis; Estados Unidos
Fil: Hu, Nan. National Cancer Institute; Estados Unidos
Fil: He, Li-Ji. Yangcheng Cancer Hospital; China
Fil: Han, Xiao-You. Shanxi Cancer Hospital; China
Fil: Taylor, Philip R.. National Institutes of Health; Estados Unidos
Fil: Goldstein, Alisa M.. National Institutes of Health; Estados Unidos
Fil: Torres, Javier. Instituto Mexicano del Seguro Social; México
Fil: Echeverry, Magdalena. Universidad del Tolima; Colombia
Fil: Ruiz-Ponte, Clara. Centro de Investigación Biomédica en Red de Enfermedades Raras; España
Fil: Teixeira, Manuel R.. Universidad de Porto; Portugal
Fil: Carvajal Carmona, Luis G.. University of California at Davis; Estados Unidos
description Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination. We found these mutations in 2 of 31 patients with HDGC (6.5%) and 9 of 331 patients with sporadic gastric cancer (2.8%). Most of these mutations had been previously associated with other types of tumors and partially co-segregated with gastric cancer in our study. Tumors that developed in patients with these mutations had a mutation signature associated with somatic homologous recombination deficiency. Our findings indicate that defects in homologous recombination increase risk for gastric cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41447
Sahasrabudhe, Ruta; Lott, Paul; Bohorquez, Mabel; Toal, Ted; Estrada, Ana P.; et al.; Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer; W B Saunders Co-Elsevier Inc; Gastroenterology; 152; 5; 4-2017; 983-986
0016-5085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41447
identifier_str_mv Sahasrabudhe, Ruta; Lott, Paul; Bohorquez, Mabel; Toal, Ted; Estrada, Ana P.; et al.; Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer; W B Saunders Co-Elsevier Inc; Gastroenterology; 152; 5; 4-2017; 983-986
0016-5085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1053/j.gastro.2016.12.010
info:eu-repo/semantics/altIdentifier/url/http://www.gastrojournal.org/article/S0016-5085(16)35521-4/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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