Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness

Autores
Ferretti, Anabela Ferretti; Larocca, Maria Cecilia; Favre, Cristian
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The survival response to glucose limitation in eukaryotic cells involves different signaling pathways highly conserved from yeasts to mammals. Upon nutritional restriction, a network driven by kinases such as the AMP dependent protein kinase (AMPK/Snf1), the Target of Rapamycin kinase (TOR), the Protein kinases A (PKA) or B (PKB/Akt) control stress defenses, cell cycle regulators, pro and anti apoptotic proteins, respiratory complexes, etc. In this work we review the state of the art in this scenario of kinase pathways, i.e. their principal effectors and links, both in yeasts and mammals. We also focus in downstream actors such as sirtuins and the Forkhead box class O transcription factors. Besides, we particularly analyze the participation of these kinases on the balance of Reactive Oxygen Species and their role in the regulation of survival during glucose deprivation. Key results on yeast stationary phase survival and the contribution of such genetics studies are discussed.
Fil: Ferretti, Anabela Ferretti. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Larocca, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Favre, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Materia
APOPTOSIS
GLUCOSE RESTRICTION
CELL DEATH
SIGNALING
ROS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280938
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarcenessFerretti, Anabela FerrettiLarocca, Maria CeciliaFavre, CristianAPOPTOSISGLUCOSE RESTRICTIONCELL DEATHSIGNALINGROShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The survival response to glucose limitation in eukaryotic cells involves different signaling pathways highly conserved from yeasts to mammals. Upon nutritional restriction, a network driven by kinases such as the AMP dependent protein kinase (AMPK/Snf1), the Target of Rapamycin kinase (TOR), the Protein kinases A (PKA) or B (PKB/Akt) control stress defenses, cell cycle regulators, pro and anti apoptotic proteins, respiratory complexes, etc. In this work we review the state of the art in this scenario of kinase pathways, i.e. their principal effectors and links, both in yeasts and mammals. We also focus in downstream actors such as sirtuins and the Forkhead box class O transcription factors. Besides, we particularly analyze the participation of these kinases on the balance of Reactive Oxygen Species and their role in the regulation of survival during glucose deprivation. Key results on yeast stationary phase survival and the contribution of such genetics studies are discussed.Fil: Ferretti, Anabela Ferretti. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Larocca, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Favre, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaAcademic Press Inc Elsevier Science2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280938Ferretti, Anabela Ferretti; Larocca, Maria Cecilia; Favre, Cristian; Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness; Academic Press Inc Elsevier Science; Molecular Genetics And Metabolism; 105; 2; 11-2011; 186-1921096-7192CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1096719211004240info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ymgme.2011.11.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-20T15:16:32Zoai:ri.conicet.gov.ar:11336/280938instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-20 15:16:32.986CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
title Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
spellingShingle Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
Ferretti, Anabela Ferretti
APOPTOSIS
GLUCOSE RESTRICTION
CELL DEATH
SIGNALING
ROS
title_short Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
title_full Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
title_fullStr Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
title_full_unstemmed Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
title_sort Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
dc.creator.none.fl_str_mv Ferretti, Anabela Ferretti
Larocca, Maria Cecilia
Favre, Cristian
author Ferretti, Anabela Ferretti
author_facet Ferretti, Anabela Ferretti
Larocca, Maria Cecilia
Favre, Cristian
author_role author
author2 Larocca, Maria Cecilia
Favre, Cristian
author2_role author
author
dc.subject.none.fl_str_mv APOPTOSIS
GLUCOSE RESTRICTION
CELL DEATH
SIGNALING
ROS
topic APOPTOSIS
GLUCOSE RESTRICTION
CELL DEATH
SIGNALING
ROS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The survival response to glucose limitation in eukaryotic cells involves different signaling pathways highly conserved from yeasts to mammals. Upon nutritional restriction, a network driven by kinases such as the AMP dependent protein kinase (AMPK/Snf1), the Target of Rapamycin kinase (TOR), the Protein kinases A (PKA) or B (PKB/Akt) control stress defenses, cell cycle regulators, pro and anti apoptotic proteins, respiratory complexes, etc. In this work we review the state of the art in this scenario of kinase pathways, i.e. their principal effectors and links, both in yeasts and mammals. We also focus in downstream actors such as sirtuins and the Forkhead box class O transcription factors. Besides, we particularly analyze the participation of these kinases on the balance of Reactive Oxygen Species and their role in the regulation of survival during glucose deprivation. Key results on yeast stationary phase survival and the contribution of such genetics studies are discussed.
Fil: Ferretti, Anabela Ferretti. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Larocca, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Favre, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
description The survival response to glucose limitation in eukaryotic cells involves different signaling pathways highly conserved from yeasts to mammals. Upon nutritional restriction, a network driven by kinases such as the AMP dependent protein kinase (AMPK/Snf1), the Target of Rapamycin kinase (TOR), the Protein kinases A (PKA) or B (PKB/Akt) control stress defenses, cell cycle regulators, pro and anti apoptotic proteins, respiratory complexes, etc. In this work we review the state of the art in this scenario of kinase pathways, i.e. their principal effectors and links, both in yeasts and mammals. We also focus in downstream actors such as sirtuins and the Forkhead box class O transcription factors. Besides, we particularly analyze the participation of these kinases on the balance of Reactive Oxygen Species and their role in the regulation of survival during glucose deprivation. Key results on yeast stationary phase survival and the contribution of such genetics studies are discussed.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280938
Ferretti, Anabela Ferretti; Larocca, Maria Cecilia; Favre, Cristian; Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness; Academic Press Inc Elsevier Science; Molecular Genetics And Metabolism; 105; 2; 11-2011; 186-192
1096-7192
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280938
identifier_str_mv Ferretti, Anabela Ferretti; Larocca, Maria Cecilia; Favre, Cristian; Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness; Academic Press Inc Elsevier Science; Molecular Genetics And Metabolism; 105; 2; 11-2011; 186-192
1096-7192
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1096719211004240
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ymgme.2011.11.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.9253

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