Regulation of lipid peroxidation and ferroptosis in diverse species

Autores
Conrad, Marcus; Kagan, Valerian E.; Bayir, Hülya; Pagnussat, Gabriela Carolina; Head, Brian; Traber, Maret G.; Stockwell, Brent R.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
Fil: Conrad, Marcus. Helmholtz Center Munich German Research Center For Environmental Health;
Fil: Kagan, Valerian E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Sechenov First Moscow State Medical University;
Fil: Bayir, Hülya. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Pagnussat, Gabriela Carolina. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Head, Brian. Linus Pauling Institute; . State University of Oregon; Estados Unidos
Fil: Traber, Maret G.. Linus Pauling Institute; . State University of Oregon; Estados Unidos
Fil: Stockwell, Brent R.. Columbia University; Estados Unidos
Materia
CELL DEATH
FERROPTOSIS
IRON
LIPID PEROXIDATION
ROS
VITAMIN E
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87563
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of lipid peroxidation and ferroptosis in diverse speciesConrad, MarcusKagan, Valerian E.Bayir, HülyaPagnussat, Gabriela CarolinaHead, BrianTraber, Maret G.Stockwell, Brent R.CELL DEATHFERROPTOSISIRONLIPID PEROXIDATIONROSVITAMIN Ehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.Fil: Conrad, Marcus. Helmholtz Center Munich German Research Center For Environmental Health;Fil: Kagan, Valerian E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Sechenov First Moscow State Medical University;Fil: Bayir, Hülya. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Pagnussat, Gabriela Carolina. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Head, Brian. Linus Pauling Institute; . State University of Oregon; Estados UnidosFil: Traber, Maret G.. Linus Pauling Institute; . State University of Oregon; Estados UnidosFil: Stockwell, Brent R.. Columbia University; Estados UnidosCold Spring Harbor Laboratory Press2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87563Conrad, Marcus; Kagan, Valerian E.; Bayir, Hülya; Pagnussat, Gabriela Carolina; Head, Brian; et al.; Regulation of lipid peroxidation and ferroptosis in diverse species; Cold Spring Harbor Laboratory Press; Genes & Development.; 32; 9-10; 5-2018; 602-6190890-9369CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1101/gad.314674.118info:eu-repo/semantics/altIdentifier/url/http://genesdev.cshlp.org/content/32/9-10/602info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:49Zoai:ri.conicet.gov.ar:11336/87563instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:49.592CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of lipid peroxidation and ferroptosis in diverse species
title Regulation of lipid peroxidation and ferroptosis in diverse species
spellingShingle Regulation of lipid peroxidation and ferroptosis in diverse species
Conrad, Marcus
CELL DEATH
FERROPTOSIS
IRON
LIPID PEROXIDATION
ROS
VITAMIN E
title_short Regulation of lipid peroxidation and ferroptosis in diverse species
title_full Regulation of lipid peroxidation and ferroptosis in diverse species
title_fullStr Regulation of lipid peroxidation and ferroptosis in diverse species
title_full_unstemmed Regulation of lipid peroxidation and ferroptosis in diverse species
title_sort Regulation of lipid peroxidation and ferroptosis in diverse species
dc.creator.none.fl_str_mv Conrad, Marcus
Kagan, Valerian E.
Bayir, Hülya
Pagnussat, Gabriela Carolina
Head, Brian
Traber, Maret G.
Stockwell, Brent R.
author Conrad, Marcus
author_facet Conrad, Marcus
Kagan, Valerian E.
Bayir, Hülya
Pagnussat, Gabriela Carolina
Head, Brian
Traber, Maret G.
Stockwell, Brent R.
author_role author
author2 Kagan, Valerian E.
Bayir, Hülya
Pagnussat, Gabriela Carolina
Head, Brian
Traber, Maret G.
Stockwell, Brent R.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CELL DEATH
FERROPTOSIS
IRON
LIPID PEROXIDATION
ROS
VITAMIN E
topic CELL DEATH
FERROPTOSIS
IRON
LIPID PEROXIDATION
ROS
VITAMIN E
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
Fil: Conrad, Marcus. Helmholtz Center Munich German Research Center For Environmental Health;
Fil: Kagan, Valerian E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Sechenov First Moscow State Medical University;
Fil: Bayir, Hülya. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Pagnussat, Gabriela Carolina. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Head, Brian. Linus Pauling Institute; . State University of Oregon; Estados Unidos
Fil: Traber, Maret G.. Linus Pauling Institute; . State University of Oregon; Estados Unidos
Fil: Stockwell, Brent R.. Columbia University; Estados Unidos
description Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87563
Conrad, Marcus; Kagan, Valerian E.; Bayir, Hülya; Pagnussat, Gabriela Carolina; Head, Brian; et al.; Regulation of lipid peroxidation and ferroptosis in diverse species; Cold Spring Harbor Laboratory Press; Genes & Development.; 32; 9-10; 5-2018; 602-619
0890-9369
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87563
identifier_str_mv Conrad, Marcus; Kagan, Valerian E.; Bayir, Hülya; Pagnussat, Gabriela Carolina; Head, Brian; et al.; Regulation of lipid peroxidation and ferroptosis in diverse species; Cold Spring Harbor Laboratory Press; Genes & Development.; 32; 9-10; 5-2018; 602-619
0890-9369
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1101/gad.314674.118
info:eu-repo/semantics/altIdentifier/url/http://genesdev.cshlp.org/content/32/9-10/602
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613260011110400
score 13.070432

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