Keeping the rhythm: the impact of circadian clock on the immune response to cancer

Autores
Aiello, Ignacio; Hokama, Guido; Senna, Camila Agustina; Golombek, Diego Andrés; Paladino, Natalia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The circadian clock, responsible for the regulation of physiological and behavioral functions in the body, has been found to play a significant role in the development of cancer. Studies have shown that circadian disruption due to atypical activity periods or shift work may lead to several types of cancer, including breast, prostate, and colorectal cancer. The development of cancer and its response to therapeutic protocols are strongly influenced by innate and adaptive immune systems. Indeed, the balance between the activation of inflammatory pathways and immunological tolerance is crucial for tumor development. Macrophages, which play a determinant role in the immune response to the tumor, can differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) profiles depending on the signals they receive. In this work, we try to unveil how the circadian clock plays a significant part in the regulation of tumor immunity, focusing mainly on macrophages present in the tumor. Daily patterns in the presence and function of several leukocytes, including macrophages and dendritic cells, have been observed in the tumor context. In addition, the relation between the major profiles of macrophages, M1 and M2, is compromised under conditions that disrupt the circadian clock, favoring the immunological tolerance in the tumor microenvironment and, thus, helping the tumor to escape immune surveillance. On the other hand, the presence of the tumor itself affects the circadian system, which could initiate a vicious circle in which the circadian clock gets worse along with tumor progression, affecting the macrophages present in the tumor,among other leukocytes, favoring a more tolerogenic immunity within the tumor.
Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Hokama, Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Universidad de San Andrés; Argentina
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Materia
RITMOS CIRCADIANOS
CANCER
SISTEMA INMUNE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/237638
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Keeping the rhythm: the impact of circadian clock on the immune response to cancerAiello, IgnacioHokama, GuidoSenna, Camila AgustinaGolombek, Diego AndrésPaladino, NataliaRITMOS CIRCADIANOSCANCERSISTEMA INMUNEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The circadian clock, responsible for the regulation of physiological and behavioral functions in the body, has been found to play a significant role in the development of cancer. Studies have shown that circadian disruption due to atypical activity periods or shift work may lead to several types of cancer, including breast, prostate, and colorectal cancer. The development of cancer and its response to therapeutic protocols are strongly influenced by innate and adaptive immune systems. Indeed, the balance between the activation of inflammatory pathways and immunological tolerance is crucial for tumor development. Macrophages, which play a determinant role in the immune response to the tumor, can differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) profiles depending on the signals they receive. In this work, we try to unveil how the circadian clock plays a significant part in the regulation of tumor immunity, focusing mainly on macrophages present in the tumor. Daily patterns in the presence and function of several leukocytes, including macrophages and dendritic cells, have been observed in the tumor context. In addition, the relation between the major profiles of macrophages, M1 and M2, is compromised under conditions that disrupt the circadian clock, favoring the immunological tolerance in the tumor microenvironment and, thus, helping the tumor to escape immune surveillance. On the other hand, the presence of the tumor itself affects the circadian system, which could initiate a vicious circle in which the circadian clock gets worse along with tumor progression, affecting the macrophages present in the tumor,among other leukocytes, favoring a more tolerogenic immunity within the tumor.Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Hokama, Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Universidad de San Andrés; ArgentinaFil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaLatin American Association of Physiological Sciences2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/237638Aiello, Ignacio; Hokama, Guido; Senna, Camila Agustina; Golombek, Diego Andrés; Paladino, Natalia; Keeping the rhythm: the impact of circadian clock on the immune response to cancer; Latin American Association of Physiological Sciences; Physiological Mini-Reviews; 16; 2; 5-2023; 10-211669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/issue/keeping-the-rhythm-the-impact-of-circadian-clock-on-the-immune-response-to-cancer/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:38Zoai:ri.conicet.gov.ar:11336/237638instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:38.64CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Keeping the rhythm: the impact of circadian clock on the immune response to cancer
title Keeping the rhythm: the impact of circadian clock on the immune response to cancer
spellingShingle Keeping the rhythm: the impact of circadian clock on the immune response to cancer
Aiello, Ignacio
RITMOS CIRCADIANOS
CANCER
SISTEMA INMUNE
title_short Keeping the rhythm: the impact of circadian clock on the immune response to cancer
title_full Keeping the rhythm: the impact of circadian clock on the immune response to cancer
title_fullStr Keeping the rhythm: the impact of circadian clock on the immune response to cancer
title_full_unstemmed Keeping the rhythm: the impact of circadian clock on the immune response to cancer
title_sort Keeping the rhythm: the impact of circadian clock on the immune response to cancer
dc.creator.none.fl_str_mv Aiello, Ignacio
Hokama, Guido
Senna, Camila Agustina
Golombek, Diego Andrés
Paladino, Natalia
author Aiello, Ignacio
author_facet Aiello, Ignacio
Hokama, Guido
Senna, Camila Agustina
Golombek, Diego Andrés
Paladino, Natalia
author_role author
author2 Hokama, Guido
Senna, Camila Agustina
Golombek, Diego Andrés
Paladino, Natalia
author2_role author
author
author
author
dc.subject.none.fl_str_mv RITMOS CIRCADIANOS
CANCER
SISTEMA INMUNE
topic RITMOS CIRCADIANOS
CANCER
SISTEMA INMUNE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The circadian clock, responsible for the regulation of physiological and behavioral functions in the body, has been found to play a significant role in the development of cancer. Studies have shown that circadian disruption due to atypical activity periods or shift work may lead to several types of cancer, including breast, prostate, and colorectal cancer. The development of cancer and its response to therapeutic protocols are strongly influenced by innate and adaptive immune systems. Indeed, the balance between the activation of inflammatory pathways and immunological tolerance is crucial for tumor development. Macrophages, which play a determinant role in the immune response to the tumor, can differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) profiles depending on the signals they receive. In this work, we try to unveil how the circadian clock plays a significant part in the regulation of tumor immunity, focusing mainly on macrophages present in the tumor. Daily patterns in the presence and function of several leukocytes, including macrophages and dendritic cells, have been observed in the tumor context. In addition, the relation between the major profiles of macrophages, M1 and M2, is compromised under conditions that disrupt the circadian clock, favoring the immunological tolerance in the tumor microenvironment and, thus, helping the tumor to escape immune surveillance. On the other hand, the presence of the tumor itself affects the circadian system, which could initiate a vicious circle in which the circadian clock gets worse along with tumor progression, affecting the macrophages present in the tumor,among other leukocytes, favoring a more tolerogenic immunity within the tumor.
Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Hokama, Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Universidad de San Andrés; Argentina
Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
description The circadian clock, responsible for the regulation of physiological and behavioral functions in the body, has been found to play a significant role in the development of cancer. Studies have shown that circadian disruption due to atypical activity periods or shift work may lead to several types of cancer, including breast, prostate, and colorectal cancer. The development of cancer and its response to therapeutic protocols are strongly influenced by innate and adaptive immune systems. Indeed, the balance between the activation of inflammatory pathways and immunological tolerance is crucial for tumor development. Macrophages, which play a determinant role in the immune response to the tumor, can differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) profiles depending on the signals they receive. In this work, we try to unveil how the circadian clock plays a significant part in the regulation of tumor immunity, focusing mainly on macrophages present in the tumor. Daily patterns in the presence and function of several leukocytes, including macrophages and dendritic cells, have been observed in the tumor context. In addition, the relation between the major profiles of macrophages, M1 and M2, is compromised under conditions that disrupt the circadian clock, favoring the immunological tolerance in the tumor microenvironment and, thus, helping the tumor to escape immune surveillance. On the other hand, the presence of the tumor itself affects the circadian system, which could initiate a vicious circle in which the circadian clock gets worse along with tumor progression, affecting the macrophages present in the tumor,among other leukocytes, favoring a more tolerogenic immunity within the tumor.
publishDate 2023
dc.date.none.fl_str_mv 2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/237638
Aiello, Ignacio; Hokama, Guido; Senna, Camila Agustina; Golombek, Diego Andrés; Paladino, Natalia; Keeping the rhythm: the impact of circadian clock on the immune response to cancer; Latin American Association of Physiological Sciences; Physiological Mini-Reviews; 16; 2; 5-2023; 10-21
1669-5410
CONICET Digital
CONICET
url http://hdl.handle.net/11336/237638
identifier_str_mv Aiello, Ignacio; Hokama, Guido; Senna, Camila Agustina; Golombek, Diego Andrés; Paladino, Natalia; Keeping the rhythm: the impact of circadian clock on the immune response to cancer; Latin American Association of Physiological Sciences; Physiological Mini-Reviews; 16; 2; 5-2023; 10-21
1669-5410
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/issue/keeping-the-rhythm-the-impact-of-circadian-clock-on-the-immune-response-to-cancer/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Latin American Association of Physiological Sciences
publisher.none.fl_str_mv Latin American Association of Physiological Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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