Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1

• Autores: Soni, Sanjeev Kumar; Basu, Priyoneel; Singaravel, Muniyandi; Sharma, Ramaswamy; Pandi Perumal, Seithikurippu R.; Cardinali, Daniel Pedro; Reiter, Russel J.
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Cellular and Molecular Life Sciences. 2021, 78
• Materia: CALCIO; RITMO CIRCADIANO; CORAZON; MELATONINA; SIRTUINA
• Institución: Pontificia Universidad Católica Argentina

Fil: Soni, Sanjeev Kumar. Banaras Hindu University. Institute of Sciences. Department of Zoology. Chronobiology Laboratory; India
Fil: Basu, Priyoneel. Banaras Hindu University. Institute of Sciences. Department of Zoology. Chronobiology Laboratory; India
Fil: Singaravel, Muniyandi. Banaras Hindu University. Institute of Sciences. Department of Zoology. Chronobiology Laboratory; India
Fil: Sharma, Ramaswamy. UT Health San Antonio. Department of Cell Systems and Anatomy; Estados Unidos
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada; Canadá
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Abstract: Chronic disruption of circadian rhythms which include intricate molecular transcription-translation feedback loops of evolutionarily conserved clock genes has serious health consequences and negatively affects cardiovascular physiology. Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clock with clock-controlled oscillatory protein, NAMPT, and its metabolite NAD+. Sirtuins are linked to the multi-organ protective role of melatonin, particularly in acute kidney injury and in cardiovascular diseases, where melatonin, via upregulation of SIRT1 expression, inhibits the apoptotic pathway. This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK. SIRT1 is involved in the development of cardiomyocytes, regulation of voltage-gated cardiac sodium ion channels via deacetylation, prevention of atherosclerotic plaque formation in the cardiovascular system, protection against oxidative damage and anti-thrombotic actions. Overall, SIRT1 has a see-saw effect on cardioprotection, with low levels being cardioprotective and higher levels leading to cardiac hypertrophy.