Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
- Autores
- Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; Ericson, Per G. P.; Pol, Diego; Sánchez Villagra, Marcelo R.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.
Fil: Müllera, Johannes. Universität zu Berlin; Alemania
Fil: Scheyer, Torsten M.. Universitat Zurich; Suiza
Fil: Head, Jason J.. University of Toronto; Canadá
Fil: Barrett, Paul M.. Natural History Museum; Reino Unido
Fil: Werneburg, Ingmar. Universitat Zurich; Suiza
Fil: Ericson, Per G. P.. Swedish Museum of Natural History; Suecia
Fil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; Argentina
Fil: Sánchez Villagra, Marcelo R.. Universitat Zurich; Suiza - Materia
-
CONSTRAINT
DEVELOPMENT
HOX GENES
PALEONTOLOGY
SEGMENTATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/66668
Ver los metadatos del registro completo
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Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotesMüllera, JohannesScheyer, Torsten M.Head, Jason J.Barrett, Paul M.Werneburg, IngmarEricson, Per G. P.Pol, DiegoSánchez Villagra, Marcelo R.CONSTRAINTDEVELOPMENTHOX GENESPALEONTOLOGYSEGMENTATIONhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.Fil: Müllera, Johannes. Universität zu Berlin; AlemaniaFil: Scheyer, Torsten M.. Universitat Zurich; SuizaFil: Head, Jason J.. University of Toronto; CanadáFil: Barrett, Paul M.. Natural History Museum; Reino UnidoFil: Werneburg, Ingmar. Universitat Zurich; SuizaFil: Ericson, Per G. P.. Swedish Museum of Natural History; SueciaFil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: Sánchez Villagra, Marcelo R.. Universitat Zurich; SuizaNational Academy of Sciences2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66668Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-21230027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0912622107info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/5/2118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:02Zoai:ri.conicet.gov.ar:11336/66668instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:03.26CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
title |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
spellingShingle |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes Müllera, Johannes CONSTRAINT DEVELOPMENT HOX GENES PALEONTOLOGY SEGMENTATION |
title_short |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
title_full |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
title_fullStr |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
title_full_unstemmed |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
title_sort |
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes |
dc.creator.none.fl_str_mv |
Müllera, Johannes Scheyer, Torsten M. Head, Jason J. Barrett, Paul M. Werneburg, Ingmar Ericson, Per G. P. Pol, Diego Sánchez Villagra, Marcelo R. |
author |
Müllera, Johannes |
author_facet |
Müllera, Johannes Scheyer, Torsten M. Head, Jason J. Barrett, Paul M. Werneburg, Ingmar Ericson, Per G. P. Pol, Diego Sánchez Villagra, Marcelo R. |
author_role |
author |
author2 |
Scheyer, Torsten M. Head, Jason J. Barrett, Paul M. Werneburg, Ingmar Ericson, Per G. P. Pol, Diego Sánchez Villagra, Marcelo R. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
CONSTRAINT DEVELOPMENT HOX GENES PALEONTOLOGY SEGMENTATION |
topic |
CONSTRAINT DEVELOPMENT HOX GENES PALEONTOLOGY SEGMENTATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.5 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes. Fil: Müllera, Johannes. Universität zu Berlin; Alemania Fil: Scheyer, Torsten M.. Universitat Zurich; Suiza Fil: Head, Jason J.. University of Toronto; Canadá Fil: Barrett, Paul M.. Natural History Museum; Reino Unido Fil: Werneburg, Ingmar. Universitat Zurich; Suiza Fil: Ericson, Per G. P.. Swedish Museum of Natural History; Suecia Fil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; Argentina Fil: Sánchez Villagra, Marcelo R.. Universitat Zurich; Suiza |
description |
The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/66668 Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-2123 0027-8424 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/66668 |
identifier_str_mv |
Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-2123 0027-8424 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0912622107 info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/5/2118 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
National Academy of Sciences |
publisher.none.fl_str_mv |
National Academy of Sciences |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613494440198144 |
score |
13.070432 |