Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes

Autores
Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; Ericson, Per G. P.; Pol, Diego; Sánchez Villagra, Marcelo R.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.
Fil: Müllera, Johannes. Universität zu Berlin; Alemania
Fil: Scheyer, Torsten M.. Universitat Zurich; Suiza
Fil: Head, Jason J.. University of Toronto; Canadá
Fil: Barrett, Paul M.. Natural History Museum; Reino Unido
Fil: Werneburg, Ingmar. Universitat Zurich; Suiza
Fil: Ericson, Per G. P.. Swedish Museum of Natural History; Suecia
Fil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; Argentina
Fil: Sánchez Villagra, Marcelo R.. Universitat Zurich; Suiza
Materia
CONSTRAINT
DEVELOPMENT
HOX GENES
PALEONTOLOGY
SEGMENTATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66668
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/66668
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotesMüllera, JohannesScheyer, Torsten M.Head, Jason J.Barrett, Paul M.Werneburg, IngmarEricson, Per G. P.Pol, DiegoSánchez Villagra, Marcelo R.CONSTRAINTDEVELOPMENTHOX GENESPALEONTOLOGYSEGMENTATIONhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.Fil: Müllera, Johannes. Universität zu Berlin; AlemaniaFil: Scheyer, Torsten M.. Universitat Zurich; SuizaFil: Head, Jason J.. University of Toronto; CanadáFil: Barrett, Paul M.. Natural History Museum; Reino UnidoFil: Werneburg, Ingmar. Universitat Zurich; SuizaFil: Ericson, Per G. P.. Swedish Museum of Natural History; SueciaFil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: Sánchez Villagra, Marcelo R.. Universitat Zurich; SuizaNational Academy of Sciences2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66668Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-21230027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0912622107info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/5/2118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:53Zoai:ri.conicet.gov.ar:11336/66668instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:53.708CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
title Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
spellingShingle Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
Müllera, Johannes
CONSTRAINT
DEVELOPMENT
HOX GENES
PALEONTOLOGY
SEGMENTATION
title_short Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
title_full Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
title_fullStr Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
title_full_unstemmed Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
title_sort Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes
dc.creator.none.fl_str_mv Müllera, Johannes
Scheyer, Torsten M.
Head, Jason J.
Barrett, Paul M.
Werneburg, Ingmar
Ericson, Per G. P.
Pol, Diego
Sánchez Villagra, Marcelo R.
author Müllera, Johannes
author_facet Müllera, Johannes
Scheyer, Torsten M.
Head, Jason J.
Barrett, Paul M.
Werneburg, Ingmar
Ericson, Per G. P.
Pol, Diego
Sánchez Villagra, Marcelo R.
author_role author
author2 Scheyer, Torsten M.
Head, Jason J.
Barrett, Paul M.
Werneburg, Ingmar
Ericson, Per G. P.
Pol, Diego
Sánchez Villagra, Marcelo R.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CONSTRAINT
DEVELOPMENT
HOX GENES
PALEONTOLOGY
SEGMENTATION
topic CONSTRAINT
DEVELOPMENT
HOX GENES
PALEONTOLOGY
SEGMENTATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.
Fil: Müllera, Johannes. Universität zu Berlin; Alemania
Fil: Scheyer, Torsten M.. Universitat Zurich; Suiza
Fil: Head, Jason J.. University of Toronto; Canadá
Fil: Barrett, Paul M.. Natural History Museum; Reino Unido
Fil: Werneburg, Ingmar. Universitat Zurich; Suiza
Fil: Ericson, Per G. P.. Swedish Museum of Natural History; Suecia
Fil: Pol, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; Argentina
Fil: Sánchez Villagra, Marcelo R.. Universitat Zurich; Suiza
description The development of distinct regions in the amniote vertebral column results from somite formation and Hox gene expression, with the adult morphology displaying remarkable variation among lineages. Mammalian regionalization is reportedly very conservative or even constrained, but there has been no study investigating vertebral count variation across Amniota as a whole, undermining attempts to understand the phylogenetic, ecological, and developmental factors affecting vertebral column variation. Here, we show that the mammalian (synapsid) and reptilian lineages show early in their evolutionary histories clear divergences in axial developmental plasticity, in terms of both regionalization and meristic change, with basal synapsids sharing the conserved axial configuration of crown mammals, and basal reptiles demonstrating the plasticity of extant taxa. We conducted a comprehensive survey of presacral vertebral counts across 436 recent and extinct amniote taxa. Vertebral counts were mapped onto a generalized amniote phylogeny as well as individual ingroup trees, and ancestral states were reconstructed by using squared-changeparsimony. We also calculated the relationship between presacral and cervical numbers to infer the relative influence of homeotic effects and meristic changes and found no correlation between somitogenesis and Hox-mediated regionalization. Although conservatism in presacral numbers characterized early synapsid lineages, in some cases reptiles and synapsids exhibit the same developmental innovations in response to similar selective pressures. Conversely, increases in body mass are not coupled with meristic or homeotic changes, but mostly occur in concert with postembryonic somatic growth. Our study highlights the importance of fossils in large-scale investigations of evolutionary developmental processes.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66668
Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-2123
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66668
identifier_str_mv Müllera, Johannes; Scheyer, Torsten M.; Head, Jason J.; Barrett, Paul M.; Werneburg, Ingmar; et al.; Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 5; 2-2010; 2118-2123
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0912622107
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/5/2118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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