Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability

Autores
Montiel Schneider, María Gabriela; Rivero, Paula Sofia; Muñoz Medina, Guillermo Arturo; Sanchez, Francisco Homero; Lassalle, Verónica Leticia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Magnetic resonance imaging is one of the most widely used diagnostic techniques, since it is non-invasive and provides high spatial resolution. Contrast agents (CAs) are usually required to improve the contrast capability. CAs can be classified as T1 (or positive) or T2 (or negative) contrast agents. Nowadays, gadolinium chelates (which generate T1 contrast) are the most used in clinical settings. However, the use of these chelates presents some drawbacks associated with their toxicity. Iron oxide magnetic nanoparticles (MNPs) have been extensively investigated as CA for MRI, especially for their capacity to generate negative contrast. The need for more efficient and safer contrast agents has focused investigations on the development of dual CAs, i.e., CAs that can generate both positive and negative contrast with a single administration. In this sense, nanotechnology appears as an attractive tool to achieve this goal. Nanoparticles can be modified not only to improve the contrast ability of the current CAs but also to enhance their biocompatibility, resolving toxicity issues. With the aim of contributing to the field of development of dual T1/T2 contrast agents for MRI, here, we present the obtained results of the synthesis of hybrid nanoparticles composed of magnetite/maghemite and gadolinium hydroxide. Exhaustive characterization work was conducted in order to understand how the hybrid nanoparticles were formed. The nanoparticles were extensively characterized through FTIR and UV?Vis spectroscopy, TEM and SEM microscopy, X-ray diffraction (XRD) analysis, dynamic light scattering, zeta potential, thermogravimetric analysis, energy-dispersive X-ray and vibrating-sample magnetometry. Stabilization studies were carried out to get an idea of the behavior of nanohybrids in physiological media. Special interest was given to the evaluation of Gd3+ leaching. It was found that carbohydrate coating as well as the adsorption of proteins on the surface may improve the stabilization of hybrid nanoparticles.
Fil: Montiel Schneider, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Rivero, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Muñoz Medina, Guillermo Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
Nanomagnetism
Magnetic resonance imaging
Iron oxides
Contrast agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240641
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and StabilityMontiel Schneider, María GabrielaRivero, Paula SofiaMuñoz Medina, Guillermo ArturoSanchez, Francisco HomeroLassalle, Verónica LeticiaNanomagnetismMagnetic resonance imagingIron oxidesContrast agentshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Magnetic resonance imaging is one of the most widely used diagnostic techniques, since it is non-invasive and provides high spatial resolution. Contrast agents (CAs) are usually required to improve the contrast capability. CAs can be classified as T1 (or positive) or T2 (or negative) contrast agents. Nowadays, gadolinium chelates (which generate T1 contrast) are the most used in clinical settings. However, the use of these chelates presents some drawbacks associated with their toxicity. Iron oxide magnetic nanoparticles (MNPs) have been extensively investigated as CA for MRI, especially for their capacity to generate negative contrast. The need for more efficient and safer contrast agents has focused investigations on the development of dual CAs, i.e., CAs that can generate both positive and negative contrast with a single administration. In this sense, nanotechnology appears as an attractive tool to achieve this goal. Nanoparticles can be modified not only to improve the contrast ability of the current CAs but also to enhance their biocompatibility, resolving toxicity issues. With the aim of contributing to the field of development of dual T1/T2 contrast agents for MRI, here, we present the obtained results of the synthesis of hybrid nanoparticles composed of magnetite/maghemite and gadolinium hydroxide. Exhaustive characterization work was conducted in order to understand how the hybrid nanoparticles were formed. The nanoparticles were extensively characterized through FTIR and UV?Vis spectroscopy, TEM and SEM microscopy, X-ray diffraction (XRD) analysis, dynamic light scattering, zeta potential, thermogravimetric analysis, energy-dispersive X-ray and vibrating-sample magnetometry. Stabilization studies were carried out to get an idea of the behavior of nanohybrids in physiological media. Special interest was given to the evaluation of Gd3+ leaching. It was found that carbohydrate coating as well as the adsorption of proteins on the surface may improve the stabilization of hybrid nanoparticles.Fil: Montiel Schneider, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Rivero, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Muñoz Medina, Guillermo Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaMDPI2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240641Montiel Schneider, María Gabriela; Rivero, Paula Sofia; Muñoz Medina, Guillermo Arturo; Sanchez, Francisco Homero; Lassalle, Verónica Leticia; Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability; MDPI; colloids and interfaces; 7; 1; 1-2023; 2-162504-5377CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/7/1/8info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids7010008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:22Zoai:ri.conicet.gov.ar:11336/240641instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:22.751CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
title Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
spellingShingle Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
Montiel Schneider, María Gabriela
Nanomagnetism
Magnetic resonance imaging
Iron oxides
Contrast agents
title_short Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
title_full Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
title_fullStr Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
title_full_unstemmed Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
title_sort Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability
dc.creator.none.fl_str_mv Montiel Schneider, María Gabriela
Rivero, Paula Sofia
Muñoz Medina, Guillermo Arturo
Sanchez, Francisco Homero
Lassalle, Verónica Leticia
author Montiel Schneider, María Gabriela
author_facet Montiel Schneider, María Gabriela
Rivero, Paula Sofia
Muñoz Medina, Guillermo Arturo
Sanchez, Francisco Homero
Lassalle, Verónica Leticia
author_role author
author2 Rivero, Paula Sofia
Muñoz Medina, Guillermo Arturo
Sanchez, Francisco Homero
Lassalle, Verónica Leticia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanomagnetism
Magnetic resonance imaging
Iron oxides
Contrast agents
topic Nanomagnetism
Magnetic resonance imaging
Iron oxides
Contrast agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Magnetic resonance imaging is one of the most widely used diagnostic techniques, since it is non-invasive and provides high spatial resolution. Contrast agents (CAs) are usually required to improve the contrast capability. CAs can be classified as T1 (or positive) or T2 (or negative) contrast agents. Nowadays, gadolinium chelates (which generate T1 contrast) are the most used in clinical settings. However, the use of these chelates presents some drawbacks associated with their toxicity. Iron oxide magnetic nanoparticles (MNPs) have been extensively investigated as CA for MRI, especially for their capacity to generate negative contrast. The need for more efficient and safer contrast agents has focused investigations on the development of dual CAs, i.e., CAs that can generate both positive and negative contrast with a single administration. In this sense, nanotechnology appears as an attractive tool to achieve this goal. Nanoparticles can be modified not only to improve the contrast ability of the current CAs but also to enhance their biocompatibility, resolving toxicity issues. With the aim of contributing to the field of development of dual T1/T2 contrast agents for MRI, here, we present the obtained results of the synthesis of hybrid nanoparticles composed of magnetite/maghemite and gadolinium hydroxide. Exhaustive characterization work was conducted in order to understand how the hybrid nanoparticles were formed. The nanoparticles were extensively characterized through FTIR and UV?Vis spectroscopy, TEM and SEM microscopy, X-ray diffraction (XRD) analysis, dynamic light scattering, zeta potential, thermogravimetric analysis, energy-dispersive X-ray and vibrating-sample magnetometry. Stabilization studies were carried out to get an idea of the behavior of nanohybrids in physiological media. Special interest was given to the evaluation of Gd3+ leaching. It was found that carbohydrate coating as well as the adsorption of proteins on the surface may improve the stabilization of hybrid nanoparticles.
Fil: Montiel Schneider, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Rivero, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Muñoz Medina, Guillermo Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Sanchez, Francisco Homero. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description Magnetic resonance imaging is one of the most widely used diagnostic techniques, since it is non-invasive and provides high spatial resolution. Contrast agents (CAs) are usually required to improve the contrast capability. CAs can be classified as T1 (or positive) or T2 (or negative) contrast agents. Nowadays, gadolinium chelates (which generate T1 contrast) are the most used in clinical settings. However, the use of these chelates presents some drawbacks associated with their toxicity. Iron oxide magnetic nanoparticles (MNPs) have been extensively investigated as CA for MRI, especially for their capacity to generate negative contrast. The need for more efficient and safer contrast agents has focused investigations on the development of dual CAs, i.e., CAs that can generate both positive and negative contrast with a single administration. In this sense, nanotechnology appears as an attractive tool to achieve this goal. Nanoparticles can be modified not only to improve the contrast ability of the current CAs but also to enhance their biocompatibility, resolving toxicity issues. With the aim of contributing to the field of development of dual T1/T2 contrast agents for MRI, here, we present the obtained results of the synthesis of hybrid nanoparticles composed of magnetite/maghemite and gadolinium hydroxide. Exhaustive characterization work was conducted in order to understand how the hybrid nanoparticles were formed. The nanoparticles were extensively characterized through FTIR and UV?Vis spectroscopy, TEM and SEM microscopy, X-ray diffraction (XRD) analysis, dynamic light scattering, zeta potential, thermogravimetric analysis, energy-dispersive X-ray and vibrating-sample magnetometry. Stabilization studies were carried out to get an idea of the behavior of nanohybrids in physiological media. Special interest was given to the evaluation of Gd3+ leaching. It was found that carbohydrate coating as well as the adsorption of proteins on the surface may improve the stabilization of hybrid nanoparticles.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240641
Montiel Schneider, María Gabriela; Rivero, Paula Sofia; Muñoz Medina, Guillermo Arturo; Sanchez, Francisco Homero; Lassalle, Verónica Leticia; Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability; MDPI; colloids and interfaces; 7; 1; 1-2023; 2-16
2504-5377
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240641
identifier_str_mv Montiel Schneider, María Gabriela; Rivero, Paula Sofia; Muñoz Medina, Guillermo Arturo; Sanchez, Francisco Homero; Lassalle, Verónica Leticia; Gd(OH)3 as Modifier of Iron Oxide Nanoparticles—Insights on the Synthesis, Characterization and Stability; MDPI; colloids and interfaces; 7; 1; 1-2023; 2-16
2504-5377
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/7/1/8
info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids7010008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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