Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

Autores
Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; Romanowski, Andrés; Brydon, Jack; Ball, Kathryn L.; Stanley-Wall, Nicola R.; Doitsidou, Maria
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.
Fil: Goya, María Eugenia. University of Edinburgh; Reino Unido
Fil: Xue, Feng. University of Edinburgh; Reino Unido
Fil: Sampedro Torres Quevedo, Cristina. University of Edinburgh; Reino Unido
Fil: Arnaouteli, Sofia. University Of Dundee; Reino Unido
Fil: Riquelme Dominguez, Lourdes. University of Edinburgh; Reino Unido
Fil: Romanowski, Andrés. University of Edinburgh; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Brydon, Jack. University of Edinburgh; Reino Unido
Fil: Ball, Kathryn L.. University of Edinburgh; Reino Unido
Fil: Stanley-Wall, Nicola R.. University Of Dundee; Reino Unido
Fil: Doitsidou, Maria. University of Edinburgh; Reino Unido
Materia
B. SUBTILIS
BIOFILM
C. ELEGANS
DAF-16/FOXO
DIETARY RESTRICTION
MICROBIOTA
PARKINSON'S DISEASE
PROBIOTICS
SPHINGOLIPID METABOLISM
Α-SYNUCLEIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134063
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/134063
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegansGoya, María EugeniaXue, FengSampedro Torres Quevedo, CristinaArnaouteli, SofiaRiquelme Dominguez, LourdesRomanowski, AndrésBrydon, JackBall, Kathryn L.Stanley-Wall, Nicola R.Doitsidou, MariaB. SUBTILISBIOFILMC. ELEGANSDAF-16/FOXODIETARY RESTRICTIONMICROBIOTAPARKINSON'S DISEASEPROBIOTICSSPHINGOLIPID METABOLISMΑ-SYNUCLEINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.Fil: Goya, María Eugenia. University of Edinburgh; Reino UnidoFil: Xue, Feng. University of Edinburgh; Reino UnidoFil: Sampedro Torres Quevedo, Cristina. University of Edinburgh; Reino UnidoFil: Arnaouteli, Sofia. University Of Dundee; Reino UnidoFil: Riquelme Dominguez, Lourdes. University of Edinburgh; Reino UnidoFil: Romanowski, Andrés. University of Edinburgh; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Brydon, Jack. University of Edinburgh; Reino UnidoFil: Ball, Kathryn L.. University of Edinburgh; Reino UnidoFil: Stanley-Wall, Nicola R.. University Of Dundee; Reino UnidoFil: Doitsidou, Maria. University of Edinburgh; Reino UnidoElsevier2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134063Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; et al.; Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans; Elsevier; Cell Reports; 30; 2; 1-2020; 367-380.e72211-12472211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31743-7info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.12.078info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124719317437info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:49Zoai:ri.conicet.gov.ar:11336/134063instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:49.359CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
title Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
spellingShingle Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Goya, María Eugenia
B. SUBTILIS
BIOFILM
C. ELEGANS
DAF-16/FOXO
DIETARY RESTRICTION
MICROBIOTA
PARKINSON'S DISEASE
PROBIOTICS
SPHINGOLIPID METABOLISM
Α-SYNUCLEIN
title_short Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
title_full Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
title_fullStr Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
title_full_unstemmed Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
title_sort Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
dc.creator.none.fl_str_mv Goya, María Eugenia
Xue, Feng
Sampedro Torres Quevedo, Cristina
Arnaouteli, Sofia
Riquelme Dominguez, Lourdes
Romanowski, Andrés
Brydon, Jack
Ball, Kathryn L.
Stanley-Wall, Nicola R.
Doitsidou, Maria
author Goya, María Eugenia
author_facet Goya, María Eugenia
Xue, Feng
Sampedro Torres Quevedo, Cristina
Arnaouteli, Sofia
Riquelme Dominguez, Lourdes
Romanowski, Andrés
Brydon, Jack
Ball, Kathryn L.
Stanley-Wall, Nicola R.
Doitsidou, Maria
author_role author
author2 Xue, Feng
Sampedro Torres Quevedo, Cristina
Arnaouteli, Sofia
Riquelme Dominguez, Lourdes
Romanowski, Andrés
Brydon, Jack
Ball, Kathryn L.
Stanley-Wall, Nicola R.
Doitsidou, Maria
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv B. SUBTILIS
BIOFILM
C. ELEGANS
DAF-16/FOXO
DIETARY RESTRICTION
MICROBIOTA
PARKINSON'S DISEASE
PROBIOTICS
SPHINGOLIPID METABOLISM
Α-SYNUCLEIN
topic B. SUBTILIS
BIOFILM
C. ELEGANS
DAF-16/FOXO
DIETARY RESTRICTION
MICROBIOTA
PARKINSON'S DISEASE
PROBIOTICS
SPHINGOLIPID METABOLISM
Α-SYNUCLEIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.
Fil: Goya, María Eugenia. University of Edinburgh; Reino Unido
Fil: Xue, Feng. University of Edinburgh; Reino Unido
Fil: Sampedro Torres Quevedo, Cristina. University of Edinburgh; Reino Unido
Fil: Arnaouteli, Sofia. University Of Dundee; Reino Unido
Fil: Riquelme Dominguez, Lourdes. University of Edinburgh; Reino Unido
Fil: Romanowski, Andrés. University of Edinburgh; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Brydon, Jack. University of Edinburgh; Reino Unido
Fil: Ball, Kathryn L.. University of Edinburgh; Reino Unido
Fil: Stanley-Wall, Nicola R.. University Of Dundee; Reino Unido
Fil: Doitsidou, Maria. University of Edinburgh; Reino Unido
description How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134063
Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; et al.; Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans; Elsevier; Cell Reports; 30; 2; 1-2020; 367-380.e7
2211-1247
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134063
identifier_str_mv Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; et al.; Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans; Elsevier; Cell Reports; 30; 2; 1-2020; 367-380.e7
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31743-7
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.12.078
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124719317437
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269929995239424
score 13.13397

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