A deeper view into the effects of repetitive traumatic stress on aging

Autores
Andersen, Natalia Denise; Alleto, Facundo; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2018
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhance the animal’s chance of survival. In mammals, the acute fight-or-flight response leads to the release of catecholamines (CA). Perpetuated activation of this acute stress response, as is the case of patients suffering from post-traumatic stress disorder (PTSD) is associated with accelerated aging. Nevertheless the molecular and cellular mechanisms that underlie this detrimental effect remain largely obscure. Taking advantage of its relative simple anatomy, genetics, high degree of conservation and short lifespan, we introduced a model of the nematode C. elegans, to go deep into these mechanisms. C. elegans coordinates stress response by releasing the CA tyramine (TA), the structural and functional counterpart of adrenaline in mammals. We here determined that TA-deficient animals (tdc-1) exhibit increased healthspan and lifespan. On contrary, animals permanently exposed to acute stressors, have reduced lifespan and deteriorated general fitness. These detrimental effects are not observed in tdc-1 mutants suggesting that they depend on TA release. We are currently performing experiments in order to explore how neuronal architecture and function are affected by persistent activation of the fear-related response. This study was aimed to unravel how the stress response impacts on the structural, cellular and functional changes that normally occur with aging.
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alleto, Facundo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Cordoba
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
C.elegans
stress
tyramine
PostTraumatic Stress Disorder
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/161321
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A deeper view into the effects of repetitive traumatic stress on agingAndersen, Natalia DeniseAlleto, Facundode Rosa, Maria JoseRayes, Diego HernánC.elegansstresstyraminePostTraumatic Stress Disorderhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhance the animal’s chance of survival. In mammals, the acute fight-or-flight response leads to the release of catecholamines (CA). Perpetuated activation of this acute stress response, as is the case of patients suffering from post-traumatic stress disorder (PTSD) is associated with accelerated aging. Nevertheless the molecular and cellular mechanisms that underlie this detrimental effect remain largely obscure. Taking advantage of its relative simple anatomy, genetics, high degree of conservation and short lifespan, we introduced a model of the nematode C. elegans, to go deep into these mechanisms. C. elegans coordinates stress response by releasing the CA tyramine (TA), the structural and functional counterpart of adrenaline in mammals. We here determined that TA-deficient animals (tdc-1) exhibit increased healthspan and lifespan. On contrary, animals permanently exposed to acute stressors, have reduced lifespan and deteriorated general fitness. These detrimental effects are not observed in tdc-1 mutants suggesting that they depend on TA release. We are currently performing experiments in order to explore how neuronal architecture and function are affected by persistent activation of the fear-related response. This study was aimed to unravel how the stress response impacts on the structural, cellular and functional changes that normally occur with aging.Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alleto, Facundo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXXXIII Congreso Anual de la Sociedad Argentina de Investigación en NeurocienciasCordobaArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161321A deeper view into the effects of repetitive traumatic stress on aging; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Cordoba; Argentina; 2018; 86-86CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:34:40Zoai:ri.conicet.gov.ar:11336/161321instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:34:40.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A deeper view into the effects of repetitive traumatic stress on aging
title A deeper view into the effects of repetitive traumatic stress on aging
spellingShingle A deeper view into the effects of repetitive traumatic stress on aging
Andersen, Natalia Denise
C.elegans
stress
tyramine
PostTraumatic Stress Disorder
title_short A deeper view into the effects of repetitive traumatic stress on aging
title_full A deeper view into the effects of repetitive traumatic stress on aging
title_fullStr A deeper view into the effects of repetitive traumatic stress on aging
title_full_unstemmed A deeper view into the effects of repetitive traumatic stress on aging
title_sort A deeper view into the effects of repetitive traumatic stress on aging
dc.creator.none.fl_str_mv Andersen, Natalia Denise
Alleto, Facundo
de Rosa, Maria Jose
Rayes, Diego Hernán
author Andersen, Natalia Denise
author_facet Andersen, Natalia Denise
Alleto, Facundo
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Alleto, Facundo
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
dc.subject.none.fl_str_mv C.elegans
stress
tyramine
PostTraumatic Stress Disorder
topic C.elegans
stress
tyramine
PostTraumatic Stress Disorder
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhance the animal’s chance of survival. In mammals, the acute fight-or-flight response leads to the release of catecholamines (CA). Perpetuated activation of this acute stress response, as is the case of patients suffering from post-traumatic stress disorder (PTSD) is associated with accelerated aging. Nevertheless the molecular and cellular mechanisms that underlie this detrimental effect remain largely obscure. Taking advantage of its relative simple anatomy, genetics, high degree of conservation and short lifespan, we introduced a model of the nematode C. elegans, to go deep into these mechanisms. C. elegans coordinates stress response by releasing the CA tyramine (TA), the structural and functional counterpart of adrenaline in mammals. We here determined that TA-deficient animals (tdc-1) exhibit increased healthspan and lifespan. On contrary, animals permanently exposed to acute stressors, have reduced lifespan and deteriorated general fitness. These detrimental effects are not observed in tdc-1 mutants suggesting that they depend on TA release. We are currently performing experiments in order to explore how neuronal architecture and function are affected by persistent activation of the fear-related response. This study was aimed to unravel how the stress response impacts on the structural, cellular and functional changes that normally occur with aging.
Fil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alleto, Facundo. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias
Cordoba
Argentina
Sociedad Argentina de Investigación en Neurociencias
description An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhance the animal’s chance of survival. In mammals, the acute fight-or-flight response leads to the release of catecholamines (CA). Perpetuated activation of this acute stress response, as is the case of patients suffering from post-traumatic stress disorder (PTSD) is associated with accelerated aging. Nevertheless the molecular and cellular mechanisms that underlie this detrimental effect remain largely obscure. Taking advantage of its relative simple anatomy, genetics, high degree of conservation and short lifespan, we introduced a model of the nematode C. elegans, to go deep into these mechanisms. C. elegans coordinates stress response by releasing the CA tyramine (TA), the structural and functional counterpart of adrenaline in mammals. We here determined that TA-deficient animals (tdc-1) exhibit increased healthspan and lifespan. On contrary, animals permanently exposed to acute stressors, have reduced lifespan and deteriorated general fitness. These detrimental effects are not observed in tdc-1 mutants suggesting that they depend on TA release. We are currently performing experiments in order to explore how neuronal architecture and function are affected by persistent activation of the fear-related response. This study was aimed to unravel how the stress response impacts on the structural, cellular and functional changes that normally occur with aging.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/161321
A deeper view into the effects of repetitive traumatic stress on aging; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Cordoba; Argentina; 2018; 86-86
CONICET Digital
CONICET
url http://hdl.handle.net/11336/161321
identifier_str_mv A deeper view into the effects of repetitive traumatic stress on aging; XXXIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; Cordoba; Argentina; 2018; 86-86
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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