Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis

Autores
Ferraris, Maria Jimena; Bernichstein, Sophie; Pisera, Daniel Alberto; Goffin, Vincent
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
he anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.
Fil: Ferraris, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Bernichstein, Sophie. Inserm; Francia
Fil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Goffin, Vincent. Inserm; Francia
Materia
Prolactin
Del1-9-G129r-Hprl
Prolactin Receptor Antagonist
Pituitary
Proliferation
Apoptosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8384
Acceder
id CONICETDig_75d234797ae0f1b34d6beec0aa8892d9
oai_identifier_str oai:ri.conicet.gov.ar:11336/8384
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary HomeostasisFerraris, Maria JimenaBernichstein, SophiePisera, Daniel AlbertoGoffin, VincentProlactinDel1-9-G129r-HprlProlactin Receptor AntagonistPituitaryProliferationApoptosishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3he anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.Fil: Ferraris, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Bernichstein, Sophie. Inserm; FranciaFil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Goffin, Vincent. Inserm; FranciaKarger2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8384Ferraris, Maria Jimena; Bernichstein, Sophie; Pisera, Daniel Alberto; Goffin, Vincent; Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis; Karger; Neuroendocrinology; 98; 3; 9-2013; 1-90028-3835enginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/354701info:eu-repo/semantics/altIdentifier/doi/10.1159/000354701info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:48Zoai:ri.conicet.gov.ar:11336/8384instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:48.978CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
title Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
spellingShingle Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
Ferraris, Maria Jimena
Prolactin
Del1-9-G129r-Hprl
Prolactin Receptor Antagonist
Pituitary
Proliferation
Apoptosis
title_short Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
title_full Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
title_fullStr Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
title_full_unstemmed Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
title_sort Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis
dc.creator.none.fl_str_mv Ferraris, Maria Jimena
Bernichstein, Sophie
Pisera, Daniel Alberto
Goffin, Vincent
author Ferraris, Maria Jimena
author_facet Ferraris, Maria Jimena
Bernichstein, Sophie
Pisera, Daniel Alberto
Goffin, Vincent
author_role author
author2 Bernichstein, Sophie
Pisera, Daniel Alberto
Goffin, Vincent
author2_role author
author
author
dc.subject.none.fl_str_mv Prolactin
Del1-9-G129r-Hprl
Prolactin Receptor Antagonist
Pituitary
Proliferation
Apoptosis
topic Prolactin
Del1-9-G129r-Hprl
Prolactin Receptor Antagonist
Pituitary
Proliferation
Apoptosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv he anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.
Fil: Ferraris, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Bernichstein, Sophie. Inserm; Francia
Fil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Goffin, Vincent. Inserm; Francia
description he anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, the actual outcome of its autocrine/paracrine actions on pituitary cells has remained difficult to assess. The availability of the pure PRL receptor antagonist Del1-9-G129R-hPRL has been helpful to circumvent this problem. While PRL has been traditionally associated with increased cell proliferation, recent studies revealed that this hormone actually induces apoptosis and decreases proliferation of anterior pituitary cells, by mechanisms involving the PRL receptor. The aim of this short review is to overview our current understanding of the regulation of pituitary homeostasis by PRL. Moreover, studies involving Del1-9-G129R-hPRL have helped anticipate to what extent future treatments involving PRL receptor inhibitors may interfere with processes regulated by PRL at the central level.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8384
Ferraris, Maria Jimena; Bernichstein, Sophie; Pisera, Daniel Alberto; Goffin, Vincent; Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis; Karger; Neuroendocrinology; 98; 3; 9-2013; 1-9
0028-3835
url http://hdl.handle.net/11336/8384
identifier_str_mv Ferraris, Maria Jimena; Bernichstein, Sophie; Pisera, Daniel Alberto; Goffin, Vincent; Use of Prolactin Receptor Antagonist to Better Understand Prolactin Regulation of Pituitary Homeostasis; Karger; Neuroendocrinology; 98; 3; 9-2013; 1-9
0028-3835
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/354701
info:eu-repo/semantics/altIdentifier/doi/10.1159/000354701
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614305657389056
score 13.070432

Publicaciones similares