Activation of central melanocortin pathways by fenfluramine

Autores
Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; Smart, James L.; Rubinstein, Marcelo; Tatro, Jeffrey B.; Marcus, Jacob N.; Holstege, Henne; Lee, Charlotte E.; Cone, Roger D.; Elmquist, Joel K.
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.
Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos
Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos
Fil: Tecott, Laurence H.. University of California; Estados Unidos
Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos
Fil: Marcus, Jacob N.. Harvard Medical School; Estados Unidos
Fil: Holstege, Henne. Harvard Medical School; Estados Unidos
Fil: Lee, Charlotte E.. Harvard Medical School; Estados Unidos
Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos
Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos
Materia
Serotonina
Melanocortinas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79913
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79913
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activation of central melanocortin pathways by fenfluramineHeisler, Lora K.Cowley, Michael A.Tecott, Laurence H.Fan, WeiLow, Malcolm J.Smart, James L.Rubinstein, MarceloTatro, Jeffrey B.Marcus, Jacob N.Holstege, HenneLee, Charlotte E.Cone, Roger D.Elmquist, Joel K.SerotoninaMelanocortinashttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.Fil: Heisler, Lora K.. Harvard Medical School; Estados UnidosFil: Cowley, Michael A.. Oregon Health and Science University; Estados UnidosFil: Tecott, Laurence H.. University of California; Estados UnidosFil: Fan, Wei. Oregon Health and Science University; Estados UnidosFil: Low, Malcolm J.. Oregon Health and Science University; Estados UnidosFil: Smart, James L.. Oregon Health and Science University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados UnidosFil: Marcus, Jacob N.. Harvard Medical School; Estados UnidosFil: Holstege, Henne. Harvard Medical School; Estados UnidosFil: Lee, Charlotte E.. Harvard Medical School; Estados UnidosFil: Cone, Roger D.. Oregon Health and Science University; Estados UnidosFil: Elmquist, Joel K.. Harvard Medical School; Estados UnidosAmerican Association for the Advancement of Science2002-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79913Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; et al.; Activation of central melanocortin pathways by fenfluramine; American Association for the Advancement of Science; Science; 297; 5581; 7-2002; 609-6110036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.1072327info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/297/5581/609info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:35:15Zoai:ri.conicet.gov.ar:11336/79913instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:35:15.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activation of central melanocortin pathways by fenfluramine
title Activation of central melanocortin pathways by fenfluramine
spellingShingle Activation of central melanocortin pathways by fenfluramine
Heisler, Lora K.
Serotonina
Melanocortinas
title_short Activation of central melanocortin pathways by fenfluramine
title_full Activation of central melanocortin pathways by fenfluramine
title_fullStr Activation of central melanocortin pathways by fenfluramine
title_full_unstemmed Activation of central melanocortin pathways by fenfluramine
title_sort Activation of central melanocortin pathways by fenfluramine
dc.creator.none.fl_str_mv Heisler, Lora K.
Cowley, Michael A.
Tecott, Laurence H.
Fan, Wei
Low, Malcolm J.
Smart, James L.
Rubinstein, Marcelo
Tatro, Jeffrey B.
Marcus, Jacob N.
Holstege, Henne
Lee, Charlotte E.
Cone, Roger D.
Elmquist, Joel K.
author Heisler, Lora K.
author_facet Heisler, Lora K.
Cowley, Michael A.
Tecott, Laurence H.
Fan, Wei
Low, Malcolm J.
Smart, James L.
Rubinstein, Marcelo
Tatro, Jeffrey B.
Marcus, Jacob N.
Holstege, Henne
Lee, Charlotte E.
Cone, Roger D.
Elmquist, Joel K.
author_role author
author2 Cowley, Michael A.
Tecott, Laurence H.
Fan, Wei
Low, Malcolm J.
Smart, James L.
Rubinstein, Marcelo
Tatro, Jeffrey B.
Marcus, Jacob N.
Holstege, Henne
Lee, Charlotte E.
Cone, Roger D.
Elmquist, Joel K.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Serotonina
Melanocortinas
topic Serotonina
Melanocortinas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.
Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos
Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos
Fil: Tecott, Laurence H.. University of California; Estados Unidos
Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos
Fil: Marcus, Jacob N.. Harvard Medical School; Estados Unidos
Fil: Holstege, Henne. Harvard Medical School; Estados Unidos
Fil: Lee, Charlotte E.. Harvard Medical School; Estados Unidos
Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos
Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos
description D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective antiobesity treatments.
publishDate 2002
dc.date.none.fl_str_mv 2002-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79913
Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; et al.; Activation of central melanocortin pathways by fenfluramine; American Association for the Advancement of Science; Science; 297; 5581; 7-2002; 609-611
0036-8075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79913
identifier_str_mv Heisler, Lora K.; Cowley, Michael A.; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; et al.; Activation of central melanocortin pathways by fenfluramine; American Association for the Advancement of Science; Science; 297; 5581; 7-2002; 609-611
0036-8075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1072327
info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/297/5581/609
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083479102554112
score 13.22299

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