Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders

Autores
Gallo, Loreana Carolina; Piña, Juliana; Bucala, Veronica; Allemandi, Daniel Alberto; Ramírez Rigo, María Veronica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this paper was to develop a modified-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, sodium carboxymethylcellulose (Na-CMC) and colloidal silicon dioxide (SiO2) was formulated, which showed good flow properties for direct compression and was useful as a modified-release hydrophilic matrix system. H. virginiana extract was selected as a model plant extract due to its extensive use in treatments for chronic varicose veins. Different ternary co-processed powders were obtained by modifying the viscosity grade and concentration of Na-CMC. For a given set of spray-drying operating conditions, the use of medium viscosity (MV) Na-CMC in the formula led to high process yields and satisfactory product moisture contents. Compacted powders were able to modulate the extract release in different media, being the polymer concentration the fundamental factor affecting the rate of drug release. The co-spray-dried powder with a plant extract solid residue:SiO2:Na-CMC MV ratio of 1:1:0.075 was the best formulation because of its good flowability, compactability, stability and release properties. It was found that the release mechanism was a combination of extract diffusion and matrix erosion. The results indicated that the co-spray-drying of adequately designed formulations is a good strategy to improve the functionality of medicinal plant extract powders.
Fil: Gallo, Loreana Carolina. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Piña, Juliana. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Bucala, Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramírez Rigo, María Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Materia
Hamamelis Virginiana
Sodium Carboxymethylcellulose
Microparticles
Spray-Drying
Modified Release
Matricial System
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11927
Acceder
id CONICETDig_74ccc4121575f1405c303c246ea158c6
oai_identifier_str oai:ri.conicet.gov.ar:11336/11927
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powdersGallo, Loreana CarolinaPiña, JulianaBucala, VeronicaAllemandi, Daniel AlbertoRamírez Rigo, María VeronicaHamamelis VirginianaSodium CarboxymethylcelluloseMicroparticlesSpray-DryingModified ReleaseMatricial Systemhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The aim of this paper was to develop a modified-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, sodium carboxymethylcellulose (Na-CMC) and colloidal silicon dioxide (SiO2) was formulated, which showed good flow properties for direct compression and was useful as a modified-release hydrophilic matrix system. H. virginiana extract was selected as a model plant extract due to its extensive use in treatments for chronic varicose veins. Different ternary co-processed powders were obtained by modifying the viscosity grade and concentration of Na-CMC. For a given set of spray-drying operating conditions, the use of medium viscosity (MV) Na-CMC in the formula led to high process yields and satisfactory product moisture contents. Compacted powders were able to modulate the extract release in different media, being the polymer concentration the fundamental factor affecting the rate of drug release. The co-spray-dried powder with a plant extract solid residue:SiO2:Na-CMC MV ratio of 1:1:0.075 was the best formulation because of its good flowability, compactability, stability and release properties. It was found that the release mechanism was a combination of extract diffusion and matrix erosion. The results indicated that the co-spray-drying of adequately designed formulations is a good strategy to improve the functionality of medicinal plant extract powders.Fil: Gallo, Loreana Carolina. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaFil: Piña, Juliana. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaFil: Bucala, Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaFil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramírez Rigo, María Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); ArgentinaElsevier Science2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11927Gallo, Loreana Carolina; Piña, Juliana; Bucala, Veronica; Allemandi, Daniel Alberto; Ramírez Rigo, María Veronica; Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders; Elsevier Science; Powder Technology; 241; 3-2013; 252-2620032-5910enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032591013001769info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2013.03.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:57Zoai:ri.conicet.gov.ar:11336/11927instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:58.061CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
title Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
spellingShingle Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
Gallo, Loreana Carolina
Hamamelis Virginiana
Sodium Carboxymethylcellulose
Microparticles
Spray-Drying
Modified Release
Matricial System
title_short Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
title_full Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
title_fullStr Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
title_full_unstemmed Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
title_sort Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
dc.creator.none.fl_str_mv Gallo, Loreana Carolina
Piña, Juliana
Bucala, Veronica
Allemandi, Daniel Alberto
Ramírez Rigo, María Veronica
author Gallo, Loreana Carolina
author_facet Gallo, Loreana Carolina
Piña, Juliana
Bucala, Veronica
Allemandi, Daniel Alberto
Ramírez Rigo, María Veronica
author_role author
author2 Piña, Juliana
Bucala, Veronica
Allemandi, Daniel Alberto
Ramírez Rigo, María Veronica
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hamamelis Virginiana
Sodium Carboxymethylcellulose
Microparticles
Spray-Drying
Modified Release
Matricial System
topic Hamamelis Virginiana
Sodium Carboxymethylcellulose
Microparticles
Spray-Drying
Modified Release
Matricial System
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this paper was to develop a modified-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, sodium carboxymethylcellulose (Na-CMC) and colloidal silicon dioxide (SiO2) was formulated, which showed good flow properties for direct compression and was useful as a modified-release hydrophilic matrix system. H. virginiana extract was selected as a model plant extract due to its extensive use in treatments for chronic varicose veins. Different ternary co-processed powders were obtained by modifying the viscosity grade and concentration of Na-CMC. For a given set of spray-drying operating conditions, the use of medium viscosity (MV) Na-CMC in the formula led to high process yields and satisfactory product moisture contents. Compacted powders were able to modulate the extract release in different media, being the polymer concentration the fundamental factor affecting the rate of drug release. The co-spray-dried powder with a plant extract solid residue:SiO2:Na-CMC MV ratio of 1:1:0.075 was the best formulation because of its good flowability, compactability, stability and release properties. It was found that the release mechanism was a combination of extract diffusion and matrix erosion. The results indicated that the co-spray-drying of adequately designed formulations is a good strategy to improve the functionality of medicinal plant extract powders.
Fil: Gallo, Loreana Carolina. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Piña, Juliana. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Bucala, Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramírez Rigo, María Veronica. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina
description The aim of this paper was to develop a modified-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, sodium carboxymethylcellulose (Na-CMC) and colloidal silicon dioxide (SiO2) was formulated, which showed good flow properties for direct compression and was useful as a modified-release hydrophilic matrix system. H. virginiana extract was selected as a model plant extract due to its extensive use in treatments for chronic varicose veins. Different ternary co-processed powders were obtained by modifying the viscosity grade and concentration of Na-CMC. For a given set of spray-drying operating conditions, the use of medium viscosity (MV) Na-CMC in the formula led to high process yields and satisfactory product moisture contents. Compacted powders were able to modulate the extract release in different media, being the polymer concentration the fundamental factor affecting the rate of drug release. The co-spray-dried powder with a plant extract solid residue:SiO2:Na-CMC MV ratio of 1:1:0.075 was the best formulation because of its good flowability, compactability, stability and release properties. It was found that the release mechanism was a combination of extract diffusion and matrix erosion. The results indicated that the co-spray-drying of adequately designed formulations is a good strategy to improve the functionality of medicinal plant extract powders.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11927
Gallo, Loreana Carolina; Piña, Juliana; Bucala, Veronica; Allemandi, Daniel Alberto; Ramírez Rigo, María Veronica; Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders; Elsevier Science; Powder Technology; 241; 3-2013; 252-262
0032-5910
url http://hdl.handle.net/11336/11927
identifier_str_mv Gallo, Loreana Carolina; Piña, Juliana; Bucala, Veronica; Allemandi, Daniel Alberto; Ramírez Rigo, María Veronica; Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders; Elsevier Science; Powder Technology; 241; 3-2013; 252-262
0032-5910
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032591013001769
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2013.03.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268946679463936
score 13.13397

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