Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation

Autores
Gallo, Loreana Carolina; Ramírez Rigo, María Veronica; Wilson, Érica; Piña, Juliana; Allemandi, Daniel Alberto; Bucala, Veronica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cascara sagrada bark is extensively used in the treatment of occasional constipation. Despite its wide diffusion, Cascara sagrada dried extracts with good flow and compactability properties for tablet formulation by direct compression and simple methods for the determination of Cascara sagrada extract release from tablets are not available. To overcome this lack of information, this article is focused on the design of tablets based on a Cascara sagrada extract obtained by spray-drying and on the quantification of its active constituents using a novel and isocratic HPLC-UV technique, which was validated. Flow properties of the Cascara sagrada spraydried extract and of the physical mixtures of it with conventional excipients were evaluated. The different formulated powders were compacted and their properties (i.e., hardness, friability, disintegration and dissolution) were studied. The proposed tablet formulations, based on the Cascara sagrada spray-dried extract, reached the pharmacopoeial requirements for immediate release tablets. In particular, the formulas containing a superdisintegrant showed the best pharmaceutical performance. Nevertheless, the use of excipients to improve the powder flow and/or the tablets properties was not strictly necessary. Besides, the HPLC-UV method used to monitor the extract release from tablets was validated, proving to be linear within the concentration range adequate for therapeutic purposes and appropriate for routine analysis due to its simplicity, good sensitivity, accuracy and precision.
Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Wilson, Érica . Universidad de Belgrano; Argentina
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Materia
Spray Drying
Cascara Sagrada Bark
Tablets
Direct Compression
Hplc Method
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12018
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12018
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance EvaluationGallo, Loreana CarolinaRamírez Rigo, María VeronicaWilson, Érica Piña, JulianaAllemandi, Daniel AlbertoBucala, VeronicaSpray DryingCascara Sagrada BarkTabletsDirect CompressionHplc Methodhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cascara sagrada bark is extensively used in the treatment of occasional constipation. Despite its wide diffusion, Cascara sagrada dried extracts with good flow and compactability properties for tablet formulation by direct compression and simple methods for the determination of Cascara sagrada extract release from tablets are not available. To overcome this lack of information, this article is focused on the design of tablets based on a Cascara sagrada extract obtained by spray-drying and on the quantification of its active constituents using a novel and isocratic HPLC-UV technique, which was validated. Flow properties of the Cascara sagrada spraydried extract and of the physical mixtures of it with conventional excipients were evaluated. The different formulated powders were compacted and their properties (i.e., hardness, friability, disintegration and dissolution) were studied. The proposed tablet formulations, based on the Cascara sagrada spray-dried extract, reached the pharmacopoeial requirements for immediate release tablets. In particular, the formulas containing a superdisintegrant showed the best pharmaceutical performance. Nevertheless, the use of excipients to improve the powder flow and/or the tablets properties was not strictly necessary. Besides, the HPLC-UV method used to monitor the extract release from tablets was validated, proving to be linear within the concentration range adequate for therapeutic purposes and appropriate for routine analysis due to its simplicity, good sensitivity, accuracy and precision.Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaFil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaFil: Wilson, Érica . Universidad de Belgrano; ArgentinaFil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; ArgentinaInternational journal of research in pharmaceutical and biomedical sciences2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12018Gallo, Loreana Carolina; Ramírez Rigo, María Veronica; Wilson, Érica ; Piña, Juliana; Allemandi, Daniel Alberto; et al.; Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation; International journal of research in pharmaceutical and biomedical sciences; International Journal of Research in Pharmaceutical and Biomedical Sciences; 4; 4; 12-2013; 1360-13702229-3701enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:52Zoai:ri.conicet.gov.ar:11336/12018instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:53.342CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
title Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
spellingShingle Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
Gallo, Loreana Carolina
Spray Drying
Cascara Sagrada Bark
Tablets
Direct Compression
Hplc Method
title_short Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
title_full Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
title_fullStr Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
title_full_unstemmed Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
title_sort Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation
dc.creator.none.fl_str_mv Gallo, Loreana Carolina
Ramírez Rigo, María Veronica
Wilson, Érica
Piña, Juliana
Allemandi, Daniel Alberto
Bucala, Veronica
author Gallo, Loreana Carolina
author_facet Gallo, Loreana Carolina
Ramírez Rigo, María Veronica
Wilson, Érica
Piña, Juliana
Allemandi, Daniel Alberto
Bucala, Veronica
author_role author
author2 Ramírez Rigo, María Veronica
Wilson, Érica
Piña, Juliana
Allemandi, Daniel Alberto
Bucala, Veronica
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Spray Drying
Cascara Sagrada Bark
Tablets
Direct Compression
Hplc Method
topic Spray Drying
Cascara Sagrada Bark
Tablets
Direct Compression
Hplc Method
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cascara sagrada bark is extensively used in the treatment of occasional constipation. Despite its wide diffusion, Cascara sagrada dried extracts with good flow and compactability properties for tablet formulation by direct compression and simple methods for the determination of Cascara sagrada extract release from tablets are not available. To overcome this lack of information, this article is focused on the design of tablets based on a Cascara sagrada extract obtained by spray-drying and on the quantification of its active constituents using a novel and isocratic HPLC-UV technique, which was validated. Flow properties of the Cascara sagrada spraydried extract and of the physical mixtures of it with conventional excipients were evaluated. The different formulated powders were compacted and their properties (i.e., hardness, friability, disintegration and dissolution) were studied. The proposed tablet formulations, based on the Cascara sagrada spray-dried extract, reached the pharmacopoeial requirements for immediate release tablets. In particular, the formulas containing a superdisintegrant showed the best pharmaceutical performance. Nevertheless, the use of excipients to improve the powder flow and/or the tablets properties was not strictly necessary. Besides, the HPLC-UV method used to monitor the extract release from tablets was validated, proving to be linear within the concentration range adequate for therapeutic purposes and appropriate for routine analysis due to its simplicity, good sensitivity, accuracy and precision.
Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Wilson, Érica . Universidad de Belgrano; Argentina
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
description Cascara sagrada bark is extensively used in the treatment of occasional constipation. Despite its wide diffusion, Cascara sagrada dried extracts with good flow and compactability properties for tablet formulation by direct compression and simple methods for the determination of Cascara sagrada extract release from tablets are not available. To overcome this lack of information, this article is focused on the design of tablets based on a Cascara sagrada extract obtained by spray-drying and on the quantification of its active constituents using a novel and isocratic HPLC-UV technique, which was validated. Flow properties of the Cascara sagrada spraydried extract and of the physical mixtures of it with conventional excipients were evaluated. The different formulated powders were compacted and their properties (i.e., hardness, friability, disintegration and dissolution) were studied. The proposed tablet formulations, based on the Cascara sagrada spray-dried extract, reached the pharmacopoeial requirements for immediate release tablets. In particular, the formulas containing a superdisintegrant showed the best pharmaceutical performance. Nevertheless, the use of excipients to improve the powder flow and/or the tablets properties was not strictly necessary. Besides, the HPLC-UV method used to monitor the extract release from tablets was validated, proving to be linear within the concentration range adequate for therapeutic purposes and appropriate for routine analysis due to its simplicity, good sensitivity, accuracy and precision.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12018
Gallo, Loreana Carolina; Ramírez Rigo, María Veronica; Wilson, Érica ; Piña, Juliana; Allemandi, Daniel Alberto; et al.; Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation; International journal of research in pharmaceutical and biomedical sciences; International Journal of Research in Pharmaceutical and Biomedical Sciences; 4; 4; 12-2013; 1360-1370
2229-3701
url http://hdl.handle.net/11336/12018
identifier_str_mv Gallo, Loreana Carolina; Ramírez Rigo, María Veronica; Wilson, Érica ; Piña, Juliana; Allemandi, Daniel Alberto; et al.; Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation; International journal of research in pharmaceutical and biomedical sciences; International Journal of Research in Pharmaceutical and Biomedical Sciences; 4; 4; 12-2013; 1360-1370
2229-3701
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv International journal of research in pharmaceutical and biomedical sciences
publisher.none.fl_str_mv International journal of research in pharmaceutical and biomedical sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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