Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

Autores
Ciapponi, Agustín; Virgilio, Sacha Alexis; Berrueta, Mabel; Claire Soto, Natalie; Ciganda, Álvaro; Rojas Illanes, Moisés Freddy; Rubio Martinez, Briseida; Gamba, Johana; González Salazar, Carlos Arturo; Rocha Rodríguez, José Nicolás; Scarpellini, Bruno; Bravo Perdomo, Ana María; Machnicki, Gerardo; Aldunate, Leandro; De Paula, Juan; Bardach, Ariel Esteban
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and aims Ulcerative Colitis (UC) and Crohn’s Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD. Conclusions The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Virgilio, Sacha Alexis. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Claire Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rojas Illanes, Moisés Freddy. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rubio Martinez, Briseida. Hospital Dr. Bernardo Sepúlveda; México
Fil: Gamba, Johana. Fundación Universitaria Sanitas; Colombia
Fil: González Salazar, Carlos Arturo. Fundación Universitaria Sanitas; Colombia
Fil: Rocha Rodríguez, José Nicolás. Fundación Universitaria Sanitas; Colombia
Fil: Scarpellini, Bruno. No especifíca;
Fil: Bravo Perdomo, Ana María. No especifíca;
Fil: Machnicki, Gerardo. No especifíca;
Fil: Aldunate, Leandro. No especifíca;
Fil: De Paula, Juan. Hospital Italiano; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
Epidemiology
Mathematical modelling
Mexico
Colombia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142512
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series studyCiapponi, AgustínVirgilio, Sacha AlexisBerrueta, MabelClaire Soto, NatalieCiganda, ÁlvaroRojas Illanes, Moisés FreddyRubio Martinez, BriseidaGamba, JohanaGonzález Salazar, Carlos ArturoRocha Rodríguez, José NicolásScarpellini, BrunoBravo Perdomo, Ana MaríaMachnicki, GerardoAldunate, LeandroDe Paula, JuanBardach, Ariel EstebanEpidemiologyMathematical modellingMexicoColombiahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background and aims Ulcerative Colitis (UC) and Crohn’s Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD. Conclusions The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Virgilio, Sacha Alexis. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Claire Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Rojas Illanes, Moisés Freddy. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Rubio Martinez, Briseida. Hospital Dr. Bernardo Sepúlveda; MéxicoFil: Gamba, Johana. Fundación Universitaria Sanitas; ColombiaFil: González Salazar, Carlos Arturo. Fundación Universitaria Sanitas; ColombiaFil: Rocha Rodríguez, José Nicolás. Fundación Universitaria Sanitas; ColombiaFil: Scarpellini, Bruno. No especifíca;Fil: Bravo Perdomo, Ana María. No especifíca;Fil: Machnicki, Gerardo. No especifíca;Fil: Aldunate, Leandro. No especifíca;Fil: De Paula, Juan. Hospital Italiano; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaPublic Library of Science2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142512Ciapponi, Agustín; Virgilio, Sacha Alexis; Berrueta, Mabel; Claire Soto, Natalie; Ciganda, Álvaro; et al.; Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study; Public Library of Science; Plos One; 15; 1; 1-2020; 1-171932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pone.0228256info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0228256info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:50:54Zoai:ri.conicet.gov.ar:11336/142512instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:50:54.451CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
title Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
spellingShingle Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
Ciapponi, Agustín
Epidemiology
Mathematical modelling
Mexico
Colombia
title_short Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
title_full Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
title_fullStr Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
title_full_unstemmed Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
title_sort Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study
dc.creator.none.fl_str_mv Ciapponi, Agustín
Virgilio, Sacha Alexis
Berrueta, Mabel
Claire Soto, Natalie
Ciganda, Álvaro
Rojas Illanes, Moisés Freddy
Rubio Martinez, Briseida
Gamba, Johana
González Salazar, Carlos Arturo
Rocha Rodríguez, José Nicolás
Scarpellini, Bruno
Bravo Perdomo, Ana María
Machnicki, Gerardo
Aldunate, Leandro
De Paula, Juan
Bardach, Ariel Esteban
author Ciapponi, Agustín
author_facet Ciapponi, Agustín
Virgilio, Sacha Alexis
Berrueta, Mabel
Claire Soto, Natalie
Ciganda, Álvaro
Rojas Illanes, Moisés Freddy
Rubio Martinez, Briseida
Gamba, Johana
González Salazar, Carlos Arturo
Rocha Rodríguez, José Nicolás
Scarpellini, Bruno
Bravo Perdomo, Ana María
Machnicki, Gerardo
Aldunate, Leandro
De Paula, Juan
Bardach, Ariel Esteban
author_role author
author2 Virgilio, Sacha Alexis
Berrueta, Mabel
Claire Soto, Natalie
Ciganda, Álvaro
Rojas Illanes, Moisés Freddy
Rubio Martinez, Briseida
Gamba, Johana
González Salazar, Carlos Arturo
Rocha Rodríguez, José Nicolás
Scarpellini, Bruno
Bravo Perdomo, Ana María
Machnicki, Gerardo
Aldunate, Leandro
De Paula, Juan
Bardach, Ariel Esteban
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiology
Mathematical modelling
Mexico
Colombia
topic Epidemiology
Mathematical modelling
Mexico
Colombia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and aims Ulcerative Colitis (UC) and Crohn’s Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD. Conclusions The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Virgilio, Sacha Alexis. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Claire Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rojas Illanes, Moisés Freddy. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rubio Martinez, Briseida. Hospital Dr. Bernardo Sepúlveda; México
Fil: Gamba, Johana. Fundación Universitaria Sanitas; Colombia
Fil: González Salazar, Carlos Arturo. Fundación Universitaria Sanitas; Colombia
Fil: Rocha Rodríguez, José Nicolás. Fundación Universitaria Sanitas; Colombia
Fil: Scarpellini, Bruno. No especifíca;
Fil: Bravo Perdomo, Ana María. No especifíca;
Fil: Machnicki, Gerardo. No especifíca;
Fil: Aldunate, Leandro. No especifíca;
Fil: De Paula, Juan. Hospital Italiano; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Background and aims Ulcerative Colitis (UC) and Crohn’s Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD. Conclusions The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142512
Ciapponi, Agustín; Virgilio, Sacha Alexis; Berrueta, Mabel; Claire Soto, Natalie; Ciganda, Álvaro; et al.; Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study; Public Library of Science; Plos One; 15; 1; 1-2020; 1-17
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142512
identifier_str_mv Ciapponi, Agustín; Virgilio, Sacha Alexis; Berrueta, Mabel; Claire Soto, Natalie; Ciganda, Álvaro; et al.; Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study; Public Library of Science; Plos One; 15; 1; 1-2020; 1-17
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0228256
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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