Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs

Autores
Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; Sanchez Bruni, Sergio Fabian; Palma, Santiago Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
Fil: Castro, Silvina Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
Fil: Dib, Alicia. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; Uruguay
Fil: Suarez, Gonzalo. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; Uruguay
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
Materia
ALBENDAZOLE
TABLETAS RAPIDA DESINTEGRACION
CANINOS
FARMACOCINÉTICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4693
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/4693
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogsCastro, Silvina GabrielaDib, AliciaSuarez, GonzaloAllemandi, Daniel AlbertoLanusse, Carlos EdmundoSanchez Bruni, Sergio FabianPalma, Santiago DanielALBENDAZOLETABLETAS RAPIDA DESINTEGRACIONCANINOSFARMACOCINÉTICAhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.Fil: Castro, Silvina Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; ArgentinaFil: Dib, Alicia. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; UruguayFil: Suarez, Gonzalo. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; UruguayFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; ArgentinaHindawi Publishing Corporation2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4693Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; et al.; Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs; Hindawi Publishing Corporation; Biomed Research International; 2013; 7-2013; 920305-9203052314-6141enginfo:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/bmri/2013/920305/info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/920305info:eu-repo/semantics/altIdentifier/issn/2314-6141info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:28Zoai:ri.conicet.gov.ar:11336/4693instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:28.97CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
title Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
spellingShingle Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
Castro, Silvina Gabriela
ALBENDAZOLE
TABLETAS RAPIDA DESINTEGRACION
CANINOS
FARMACOCINÉTICA
title_short Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
title_full Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
title_fullStr Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
title_full_unstemmed Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
title_sort Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
dc.creator.none.fl_str_mv Castro, Silvina Gabriela
Dib, Alicia
Suarez, Gonzalo
Allemandi, Daniel Alberto
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
Palma, Santiago Daniel
author Castro, Silvina Gabriela
author_facet Castro, Silvina Gabriela
Dib, Alicia
Suarez, Gonzalo
Allemandi, Daniel Alberto
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
Palma, Santiago Daniel
author_role author
author2 Dib, Alicia
Suarez, Gonzalo
Allemandi, Daniel Alberto
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
Palma, Santiago Daniel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALBENDAZOLE
TABLETAS RAPIDA DESINTEGRACION
CANINOS
FARMACOCINÉTICA
topic ALBENDAZOLE
TABLETAS RAPIDA DESINTEGRACION
CANINOS
FARMACOCINÉTICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
Fil: Castro, Silvina Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
Fil: Dib, Alicia. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; Uruguay
Fil: Suarez, Gonzalo. Universidad de la República. Facultad de Medicina Veterinaria. Laboratorio de Farmacología; Uruguay
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
description The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4693
Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; et al.; Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs; Hindawi Publishing Corporation; Biomed Research International; 2013; 7-2013; 920305-920305
2314-6141
url http://hdl.handle.net/11336/4693
identifier_str_mv Castro, Silvina Gabriela; Dib, Alicia; Suarez, Gonzalo; Allemandi, Daniel Alberto; Lanusse, Carlos Edmundo; et al.; Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs; Hindawi Publishing Corporation; Biomed Research International; 2013; 7-2013; 920305-920305
2314-6141
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/bmri/2013/920305/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/920305
info:eu-repo/semantics/altIdentifier/issn/2314-6141
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269757762437120
score 13.13397

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