Comparative dissolution studies of albendazole oral suspensions for veterinary use

Autores
González Vidal, Noelia Luján; Starkloff, Walter Javier; Bentancor, Silvia; Castro, Silvina Gabriela; Suárez, Gonzalo Pablo; Palma, Santiago Daniel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Helminth infections are a major health problem mainly in developing countries, and the evidence of emerging resistance to all the major antihelminthics has been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelminthic agent. The biggest problem with this drug is its low aqueous solubility, which leads to an erratic availability and great intraindividual variation in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on the formulation and may lead to differences in performance among different products available in the market. In previous studies, drastic pharmacokinetic differences were observed among ABZ formulations (oral suspensions) in the Uruguayan market. These samples were evaluated in vitro in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. The in vitro dissolution rate of formulation A was seriously affected by the increase in agitation speed, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out to correlate the suspension quality with its therapeutic effectiveness.
Fil: González Vidal, Noelia Luján. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Starkloff, Walter Javier. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bentancor, Silvia. Universidad de la República; Uruguay
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Suárez, Gonzalo Pablo. Universidad de la República; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Materia
Dissolution
Albendazole
Suspension
Veterinary
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21621
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/21621
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative dissolution studies of albendazole oral suspensions for veterinary useGonzález Vidal, Noelia LujánStarkloff, Walter JavierBentancor, SilviaCastro, Silvina GabrielaSuárez, Gonzalo PabloPalma, Santiago DanielDissolutionAlbendazoleSuspensionVeterinaryhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Helminth infections are a major health problem mainly in developing countries, and the evidence of emerging resistance to all the major antihelminthics has been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelminthic agent. The biggest problem with this drug is its low aqueous solubility, which leads to an erratic availability and great intraindividual variation in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on the formulation and may lead to differences in performance among different products available in the market. In previous studies, drastic pharmacokinetic differences were observed among ABZ formulations (oral suspensions) in the Uruguayan market. These samples were evaluated in vitro in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. The in vitro dissolution rate of formulation A was seriously affected by the increase in agitation speed, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out to correlate the suspension quality with its therapeutic effectiveness.Fil: González Vidal, Noelia Luján. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Starkloff, Walter Javier. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bentancor, Silvia. Universidad de la República; UruguayFil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Suárez, Gonzalo Pablo. Universidad de la República; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaDissolution Technologies, Inc2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21621González Vidal, Noelia Luján; Starkloff, Walter Javier; Bentancor, Silvia; Castro, Silvina Gabriela; Suárez, Gonzalo Pablo; et al.; Comparative dissolution studies of albendazole oral suspensions for veterinary use; Dissolution Technologies, Inc; Dissolution Technologies; 20; 4; 12-2013; 27-301521-298XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.14227/DT200413P27info:eu-repo/semantics/altIdentifier/url/http://www.dissolutiontech.com/DTresour/BackIssuefldr/BackIssuesfrmst.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:00Zoai:ri.conicet.gov.ar:11336/21621instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:00.927CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative dissolution studies of albendazole oral suspensions for veterinary use
title Comparative dissolution studies of albendazole oral suspensions for veterinary use
spellingShingle Comparative dissolution studies of albendazole oral suspensions for veterinary use
González Vidal, Noelia Luján
Dissolution
Albendazole
Suspension
Veterinary
title_short Comparative dissolution studies of albendazole oral suspensions for veterinary use
title_full Comparative dissolution studies of albendazole oral suspensions for veterinary use
title_fullStr Comparative dissolution studies of albendazole oral suspensions for veterinary use
title_full_unstemmed Comparative dissolution studies of albendazole oral suspensions for veterinary use
title_sort Comparative dissolution studies of albendazole oral suspensions for veterinary use
dc.creator.none.fl_str_mv González Vidal, Noelia Luján
Starkloff, Walter Javier
Bentancor, Silvia
Castro, Silvina Gabriela
Suárez, Gonzalo Pablo
Palma, Santiago Daniel
author González Vidal, Noelia Luján
author_facet González Vidal, Noelia Luján
Starkloff, Walter Javier
Bentancor, Silvia
Castro, Silvina Gabriela
Suárez, Gonzalo Pablo
Palma, Santiago Daniel
author_role author
author2 Starkloff, Walter Javier
Bentancor, Silvia
Castro, Silvina Gabriela
Suárez, Gonzalo Pablo
Palma, Santiago Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Dissolution
Albendazole
Suspension
Veterinary
topic Dissolution
Albendazole
Suspension
Veterinary
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Helminth infections are a major health problem mainly in developing countries, and the evidence of emerging resistance to all the major antihelminthics has been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelminthic agent. The biggest problem with this drug is its low aqueous solubility, which leads to an erratic availability and great intraindividual variation in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on the formulation and may lead to differences in performance among different products available in the market. In previous studies, drastic pharmacokinetic differences were observed among ABZ formulations (oral suspensions) in the Uruguayan market. These samples were evaluated in vitro in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. The in vitro dissolution rate of formulation A was seriously affected by the increase in agitation speed, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out to correlate the suspension quality with its therapeutic effectiveness.
Fil: González Vidal, Noelia Luján. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Starkloff, Walter Javier. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bentancor, Silvia. Universidad de la República; Uruguay
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Suárez, Gonzalo Pablo. Universidad de la República; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
description Helminth infections are a major health problem mainly in developing countries, and the evidence of emerging resistance to all the major antihelminthics has been recognized in the field of animal husbandry. Albendazole (ABZ) is the most effective broad-spectrum antihelminthic agent. The biggest problem with this drug is its low aqueous solubility, which leads to an erratic availability and great intraindividual variation in the levels reached in different tissues. As with other poorly soluble compounds, the dissolution rate is likely to be contingent on the formulation and may lead to differences in performance among different products available in the market. In previous studies, drastic pharmacokinetic differences were observed among ABZ formulations (oral suspensions) in the Uruguayan market. These samples were evaluated in vitro in terms of ABZ content and dissolution profiles, as well as the effect of increasing agitation speeds on the dissolution rate. The in vitro dissolution rate of formulation A was seriously affected by the increase in agitation speed, and in the case of formulation B, it did not fulfill both essential quality requirements (drug content and dissolution profile). Further studies may be carried out to correlate the suspension quality with its therapeutic effectiveness.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21621
González Vidal, Noelia Luján; Starkloff, Walter Javier; Bentancor, Silvia; Castro, Silvina Gabriela; Suárez, Gonzalo Pablo; et al.; Comparative dissolution studies of albendazole oral suspensions for veterinary use; Dissolution Technologies, Inc; Dissolution Technologies; 20; 4; 12-2013; 27-30
1521-298X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21621
identifier_str_mv González Vidal, Noelia Luján; Starkloff, Walter Javier; Bentancor, Silvia; Castro, Silvina Gabriela; Suárez, Gonzalo Pablo; et al.; Comparative dissolution studies of albendazole oral suspensions for veterinary use; Dissolution Technologies, Inc; Dissolution Technologies; 20; 4; 12-2013; 27-30
1521-298X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.14227/DT200413P27
info:eu-repo/semantics/altIdentifier/url/http://www.dissolutiontech.com/DTresour/BackIssuefldr/BackIssuesfrmst.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dissolution Technologies, Inc
publisher.none.fl_str_mv Dissolution Technologies, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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