Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis
- Autores
- Diniz Luerce, Tessália; Gomes Santos, Ana Cristina; Santos Rochat, Clarissa; Garcias Moreira, Thais; Nogueira Cruz, Déborah; Lemos, Luísa; Sousa, Adna Luciana; Bastos Pereira, Vanessa; de Azevedo, Marcela; Moraes, Kátia; Carmona Cara, Denise; Leblanc, Jean Guy Joseph; Azevedo, Vasco; Caetano Faria, Ana Maria; Miyoshi, Anderson
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Many probiotic bacteria have been described as promising tools for the treatment and prevention of inflammatory bowel diseases (IBDs). Most of these bacteria are lactic acid bacteria, which are part of the healthy human microbiota. However, little is known about the effects of transient bacteria present in normal diets, including Lactococcus lactis. Methods. In the present study, we analysed the immunomodulatory effects of three L. lactis strains in vitro using intestinal epithelial cells. L. lactis NCDO 2118 was administered for 4 days to C57BL/6 mice during the remission period of colitis induced by dextran sodium sulphate (DSS). Results: Only one strain, L. lactis NCDO 2118, was able to reduce IL-1β-induced IL-8 secretion in Caco-2 cells, suggesting a potential anti-inflammatory effect. Oral treatment using L. lactis NCDO 2118 resulted in a milder form of recurrent colitis than that observed in control diseased mice. This protective effect was not attributable to changes in secretory IgA (sIgA); however, NCDO 2118 administration was associated with an early increase in IL-6 production and sustained IL-10 production in colonic tissue. Mice fed L. lactis NCDO 2118 had an increased number of regulatory CD4+T cells (Tregs) bearing surface TGF-β in its latent form (Latency-associated peptide-LAP) in the mesenteric lymph nodes and spleen. Conclusions: Here, we identified a new probiotic strain with a potential role in the treatment of IBD, and we elucidated some of the mechanisms underlying its anti-inflammatory effect.
Fil: Diniz Luerce, Tessália. Universidade Federal de Minas Gerais; Brasil
Fil: Gomes Santos, Ana Cristina. Universidade Federal de Minas Gerais; Brasil
Fil: Santos Rochat, Clarissa. Universidade Federal de Minas Gerais; Brasil
Fil: Garcias Moreira, Thais. Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Ciência de Alimentos.; Brasil
Fil: Nogueira Cruz, Déborah. Universidade Federal de Minas Gerais; Brasil
Fil: Lemos, Luísa. Universidade Federal de Minas Gerais; Brasil
Fil: Sousa, Adna Luciana. Universidade Federal de Minas Gerais; Brasil
Fil: Bastos Pereira, Vanessa. Universidade Federal de Minas Gerais; Brasil
Fil: de Azevedo, Marcela. Universidade Federal de Minas Gerais; Brasil
Fil: Moraes, Kátia. Universidade Federal de Minas Gerais; Brasil
Fil: Carmona Cara, Denise. Universidade Federal de Minas Gerais; Brasil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: Azevedo, Vasco. Universidade Federal de Minas Gerais; Brasil
Fil: Caetano Faria, Ana Maria. Universidade Federal de Minas Gerais; Brasil
Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil - Materia
-
COLITIS
CYTOKINES
LACTOCOCCUS LACTIS
PROBIOTICS
REGULATORY T CELLS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/2903
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/2903 |
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CONICET Digital (CONICET) |
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Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitisDiniz Luerce, TessáliaGomes Santos, Ana CristinaSantos Rochat, ClarissaGarcias Moreira, ThaisNogueira Cruz, DéborahLemos, LuísaSousa, Adna LucianaBastos Pereira, Vanessade Azevedo, MarcelaMoraes, KátiaCarmona Cara, DeniseLeblanc, Jean Guy JosephAzevedo, VascoCaetano Faria, Ana MariaMiyoshi, AndersonCOLITISCYTOKINESLACTOCOCCUS LACTISPROBIOTICSREGULATORY T CELLShttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Background: Many probiotic bacteria have been described as promising tools for the treatment and prevention of inflammatory bowel diseases (IBDs). Most of these bacteria are lactic acid bacteria, which are part of the healthy human microbiota. However, little is known about the effects of transient bacteria present in normal diets, including Lactococcus lactis. Methods. In the present study, we analysed the immunomodulatory effects of three L. lactis strains in vitro using intestinal epithelial cells. L. lactis NCDO 2118 was administered for 4 days to C57BL/6 mice during the remission period of colitis induced by dextran sodium sulphate (DSS). Results: Only one strain, L. lactis NCDO 2118, was able to reduce IL-1β-induced IL-8 secretion in Caco-2 cells, suggesting a potential anti-inflammatory effect. Oral treatment using L. lactis NCDO 2118 resulted in a milder form of recurrent colitis than that observed in control diseased mice. This protective effect was not attributable to changes in secretory IgA (sIgA); however, NCDO 2118 administration was associated with an early increase in IL-6 production and sustained IL-10 production in colonic tissue. Mice fed L. lactis NCDO 2118 had an increased number of regulatory CD4+T cells (Tregs) bearing surface TGF-β in its latent form (Latency-associated peptide-LAP) in the mesenteric lymph nodes and spleen. Conclusions: Here, we identified a new probiotic strain with a potential role in the treatment of IBD, and we elucidated some of the mechanisms underlying its anti-inflammatory effect.Fil: Diniz Luerce, Tessália. Universidade Federal de Minas Gerais; BrasilFil: Gomes Santos, Ana Cristina. Universidade Federal de Minas Gerais; BrasilFil: Santos Rochat, Clarissa. Universidade Federal de Minas Gerais; BrasilFil: Garcias Moreira, Thais. Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Ciência de Alimentos.; BrasilFil: Nogueira Cruz, Déborah. Universidade Federal de Minas Gerais; BrasilFil: Lemos, Luísa. Universidade Federal de Minas Gerais; BrasilFil: Sousa, Adna Luciana. Universidade Federal de Minas Gerais; BrasilFil: Bastos Pereira, Vanessa. Universidade Federal de Minas Gerais; BrasilFil: de Azevedo, Marcela. Universidade Federal de Minas Gerais; BrasilFil: Moraes, Kátia. Universidade Federal de Minas Gerais; BrasilFil: Carmona Cara, Denise. Universidade Federal de Minas Gerais; BrasilFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: Azevedo, Vasco. Universidade Federal de Minas Gerais; BrasilFil: Caetano Faria, Ana Maria. Universidade Federal de Minas Gerais; BrasilFil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; BrasilBioMed Central2014-07-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2903Diniz Luerce, Tessália; Gomes Santos, Ana Cristina; Santos Rochat, Clarissa; Garcias Moreira, Thais; Nogueira Cruz, Déborah; et al.; Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis; BioMed Central; Gut Pathogens; 6; 33; 29-7-2014; 1-111757-47491757-4749enginfo:eu-repo/semantics/altIdentifier/doi/10.1186/1757-4749-6-33info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:59:01Zoai:ri.conicet.gov.ar:11336/2903instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:59:01.791CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
title |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
spellingShingle |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis Diniz Luerce, Tessália COLITIS CYTOKINES LACTOCOCCUS LACTIS PROBIOTICS REGULATORY T CELLS |
title_short |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
title_full |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
title_fullStr |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
title_full_unstemmed |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
title_sort |
Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis |
dc.creator.none.fl_str_mv |
Diniz Luerce, Tessália Gomes Santos, Ana Cristina Santos Rochat, Clarissa Garcias Moreira, Thais Nogueira Cruz, Déborah Lemos, Luísa Sousa, Adna Luciana Bastos Pereira, Vanessa de Azevedo, Marcela Moraes, Kátia Carmona Cara, Denise Leblanc, Jean Guy Joseph Azevedo, Vasco Caetano Faria, Ana Maria Miyoshi, Anderson |
author |
Diniz Luerce, Tessália |
author_facet |
Diniz Luerce, Tessália Gomes Santos, Ana Cristina Santos Rochat, Clarissa Garcias Moreira, Thais Nogueira Cruz, Déborah Lemos, Luísa Sousa, Adna Luciana Bastos Pereira, Vanessa de Azevedo, Marcela Moraes, Kátia Carmona Cara, Denise Leblanc, Jean Guy Joseph Azevedo, Vasco Caetano Faria, Ana Maria Miyoshi, Anderson |
author_role |
author |
author2 |
Gomes Santos, Ana Cristina Santos Rochat, Clarissa Garcias Moreira, Thais Nogueira Cruz, Déborah Lemos, Luísa Sousa, Adna Luciana Bastos Pereira, Vanessa de Azevedo, Marcela Moraes, Kátia Carmona Cara, Denise Leblanc, Jean Guy Joseph Azevedo, Vasco Caetano Faria, Ana Maria Miyoshi, Anderson |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
COLITIS CYTOKINES LACTOCOCCUS LACTIS PROBIOTICS REGULATORY T CELLS |
topic |
COLITIS CYTOKINES LACTOCOCCUS LACTIS PROBIOTICS REGULATORY T CELLS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.11 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Background: Many probiotic bacteria have been described as promising tools for the treatment and prevention of inflammatory bowel diseases (IBDs). Most of these bacteria are lactic acid bacteria, which are part of the healthy human microbiota. However, little is known about the effects of transient bacteria present in normal diets, including Lactococcus lactis. Methods. In the present study, we analysed the immunomodulatory effects of three L. lactis strains in vitro using intestinal epithelial cells. L. lactis NCDO 2118 was administered for 4 days to C57BL/6 mice during the remission period of colitis induced by dextran sodium sulphate (DSS). Results: Only one strain, L. lactis NCDO 2118, was able to reduce IL-1β-induced IL-8 secretion in Caco-2 cells, suggesting a potential anti-inflammatory effect. Oral treatment using L. lactis NCDO 2118 resulted in a milder form of recurrent colitis than that observed in control diseased mice. This protective effect was not attributable to changes in secretory IgA (sIgA); however, NCDO 2118 administration was associated with an early increase in IL-6 production and sustained IL-10 production in colonic tissue. Mice fed L. lactis NCDO 2118 had an increased number of regulatory CD4+T cells (Tregs) bearing surface TGF-β in its latent form (Latency-associated peptide-LAP) in the mesenteric lymph nodes and spleen. Conclusions: Here, we identified a new probiotic strain with a potential role in the treatment of IBD, and we elucidated some of the mechanisms underlying its anti-inflammatory effect. Fil: Diniz Luerce, Tessália. Universidade Federal de Minas Gerais; Brasil Fil: Gomes Santos, Ana Cristina. Universidade Federal de Minas Gerais; Brasil Fil: Santos Rochat, Clarissa. Universidade Federal de Minas Gerais; Brasil Fil: Garcias Moreira, Thais. Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Ciência de Alimentos.; Brasil Fil: Nogueira Cruz, Déborah. Universidade Federal de Minas Gerais; Brasil Fil: Lemos, Luísa. Universidade Federal de Minas Gerais; Brasil Fil: Sousa, Adna Luciana. Universidade Federal de Minas Gerais; Brasil Fil: Bastos Pereira, Vanessa. Universidade Federal de Minas Gerais; Brasil Fil: de Azevedo, Marcela. Universidade Federal de Minas Gerais; Brasil Fil: Moraes, Kátia. Universidade Federal de Minas Gerais; Brasil Fil: Carmona Cara, Denise. Universidade Federal de Minas Gerais; Brasil Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina Fil: Azevedo, Vasco. Universidade Federal de Minas Gerais; Brasil Fil: Caetano Faria, Ana Maria. Universidade Federal de Minas Gerais; Brasil Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil |
description |
Background: Many probiotic bacteria have been described as promising tools for the treatment and prevention of inflammatory bowel diseases (IBDs). Most of these bacteria are lactic acid bacteria, which are part of the healthy human microbiota. However, little is known about the effects of transient bacteria present in normal diets, including Lactococcus lactis. Methods. In the present study, we analysed the immunomodulatory effects of three L. lactis strains in vitro using intestinal epithelial cells. L. lactis NCDO 2118 was administered for 4 days to C57BL/6 mice during the remission period of colitis induced by dextran sodium sulphate (DSS). Results: Only one strain, L. lactis NCDO 2118, was able to reduce IL-1β-induced IL-8 secretion in Caco-2 cells, suggesting a potential anti-inflammatory effect. Oral treatment using L. lactis NCDO 2118 resulted in a milder form of recurrent colitis than that observed in control diseased mice. This protective effect was not attributable to changes in secretory IgA (sIgA); however, NCDO 2118 administration was associated with an early increase in IL-6 production and sustained IL-10 production in colonic tissue. Mice fed L. lactis NCDO 2118 had an increased number of regulatory CD4+T cells (Tregs) bearing surface TGF-β in its latent form (Latency-associated peptide-LAP) in the mesenteric lymph nodes and spleen. Conclusions: Here, we identified a new probiotic strain with a potential role in the treatment of IBD, and we elucidated some of the mechanisms underlying its anti-inflammatory effect. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07-29 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/2903 Diniz Luerce, Tessália; Gomes Santos, Ana Cristina; Santos Rochat, Clarissa; Garcias Moreira, Thais; Nogueira Cruz, Déborah; et al.; Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis; BioMed Central; Gut Pathogens; 6; 33; 29-7-2014; 1-11 1757-4749 1757-4749 |
url |
http://hdl.handle.net/11336/2903 |
identifier_str_mv |
Diniz Luerce, Tessália; Gomes Santos, Ana Cristina; Santos Rochat, Clarissa; Garcias Moreira, Thais; Nogueira Cruz, Déborah; et al.; Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically-induced colitis; BioMed Central; Gut Pathogens; 6; 33; 29-7-2014; 1-11 1757-4749 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1186/1757-4749-6-33 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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12.982451 |