Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model

Autores
Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; Castro Prosperi, Camila; Gomes Santos, Ana C.; Bermudez Humaran, Luis; Caetano Faria, Ana M.; Blottiere, Hervé M.; Langella, Philippe; Miyoshi, Anderson; de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Azevedo, Vasco
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.
Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; Brasil
Fil: Morais, Kátia. Universidade Federal do Minas Gerais; Brasil
Fil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; Brasil
Fil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; Brasil
Fil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; Brasil
Fil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; Brasil
Fil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; Brasil
Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia
Fil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; Brasil
Fil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; Francia
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil
Materia
Colitis
Fermented Milk
Inflammation
Lactic Acid Bacteria
Lactococcus Lactis Lipoxygenase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28425

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oai_identifier_str oai:ri.conicet.gov.ar:11336/28425
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine modelSaraiva, Tessália D. L.Morais, KátiaPereira, Vanessa B.de Azevedo, MarcelaSantos Rocha, ClarissaCastro Prosperi, CamilaGomes Santos, Ana C.Bermudez Humaran, LuisCaetano Faria, Ana M.Blottiere, Hervé M.Langella, PhilippeMiyoshi, Andersonde Moreno, Maria AlejandraLeblanc, Jean Guy JosephAzevedo, VascoColitisFermented MilkInflammationLactic Acid BacteriaLactococcus Lactis Lipoxygenasehttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; BrasilFil: Morais, Kátia. Universidade Federal do Minas Gerais; BrasilFil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; BrasilFil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; BrasilFil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; BrasilFil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; BrasilFil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; BrasilFil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; FranciaFil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; BrasilFil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; FranciaFil: Langella, Philippe. Institut National de la Recherche Agronomique; FranciaFil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; BrasilFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Azevedo, Vasco. Universidade Federal do Minas Gerais; BrasilBentham Science Publishers2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28425Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-4291389-20101873-4316CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/ 10.2174/1389201015666141113123502info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/126090/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:43Zoai:ri.conicet.gov.ar:11336/28425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:44.095CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
title Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
spellingShingle Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
Saraiva, Tessália D. L.
Colitis
Fermented Milk
Inflammation
Lactic Acid Bacteria
Lactococcus Lactis Lipoxygenase
title_short Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
title_full Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
title_fullStr Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
title_full_unstemmed Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
title_sort Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
dc.creator.none.fl_str_mv Saraiva, Tessália D. L.
Morais, Kátia
Pereira, Vanessa B.
de Azevedo, Marcela
Santos Rocha, Clarissa
Castro Prosperi, Camila
Gomes Santos, Ana C.
Bermudez Humaran, Luis
Caetano Faria, Ana M.
Blottiere, Hervé M.
Langella, Philippe
Miyoshi, Anderson
de Moreno, Maria Alejandra
Leblanc, Jean Guy Joseph
Azevedo, Vasco
author Saraiva, Tessália D. L.
author_facet Saraiva, Tessália D. L.
Morais, Kátia
Pereira, Vanessa B.
de Azevedo, Marcela
Santos Rocha, Clarissa
Castro Prosperi, Camila
Gomes Santos, Ana C.
Bermudez Humaran, Luis
Caetano Faria, Ana M.
Blottiere, Hervé M.
Langella, Philippe
Miyoshi, Anderson
de Moreno, Maria Alejandra
Leblanc, Jean Guy Joseph
Azevedo, Vasco
author_role author
author2 Morais, Kátia
Pereira, Vanessa B.
de Azevedo, Marcela
Santos Rocha, Clarissa
Castro Prosperi, Camila
Gomes Santos, Ana C.
Bermudez Humaran, Luis
Caetano Faria, Ana M.
Blottiere, Hervé M.
Langella, Philippe
Miyoshi, Anderson
de Moreno, Maria Alejandra
Leblanc, Jean Guy Joseph
Azevedo, Vasco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Colitis
Fermented Milk
Inflammation
Lactic Acid Bacteria
Lactococcus Lactis Lipoxygenase
topic Colitis
Fermented Milk
Inflammation
Lactic Acid Bacteria
Lactococcus Lactis Lipoxygenase
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.
Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; Brasil
Fil: Morais, Kátia. Universidade Federal do Minas Gerais; Brasil
Fil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; Brasil
Fil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; Brasil
Fil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; Brasil
Fil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; Brasil
Fil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; Brasil
Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia
Fil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; Brasil
Fil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; Francia
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil
description Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28425
Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-429
1389-2010
1873-4316
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28425
identifier_str_mv Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-429
1389-2010
1873-4316
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/ 10.2174/1389201015666141113123502
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/126090/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432