Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model
- Autores
- Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; Castro Prosperi, Camila; Gomes Santos, Ana C.; Bermudez Humaran, Luis; Caetano Faria, Ana M.; Blottiere, Hervé M.; Langella, Philippe; Miyoshi, Anderson; de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Azevedo, Vasco
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.
Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; Brasil
Fil: Morais, Kátia. Universidade Federal do Minas Gerais; Brasil
Fil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; Brasil
Fil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; Brasil
Fil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; Brasil
Fil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; Brasil
Fil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; Brasil
Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia
Fil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; Brasil
Fil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; Francia
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil - Materia
-
Colitis
Fermented Milk
Inflammation
Lactic Acid Bacteria
Lactococcus Lactis Lipoxygenase - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/28425
Ver los metadatos del registro completo
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Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine modelSaraiva, Tessália D. L.Morais, KátiaPereira, Vanessa B.de Azevedo, MarcelaSantos Rocha, ClarissaCastro Prosperi, CamilaGomes Santos, Ana C.Bermudez Humaran, LuisCaetano Faria, Ana M.Blottiere, Hervé M.Langella, PhilippeMiyoshi, Andersonde Moreno, Maria AlejandraLeblanc, Jean Guy JosephAzevedo, VascoColitisFermented MilkInflammationLactic Acid BacteriaLactococcus Lactis Lipoxygenasehttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules.Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; BrasilFil: Morais, Kátia. Universidade Federal do Minas Gerais; BrasilFil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; BrasilFil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; BrasilFil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; BrasilFil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; BrasilFil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; BrasilFil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; FranciaFil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; BrasilFil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; FranciaFil: Langella, Philippe. Institut National de la Recherche Agronomique; FranciaFil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; BrasilFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Azevedo, Vasco. Universidade Federal do Minas Gerais; BrasilBentham Science Publishers2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28425Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-4291389-20101873-4316CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/ 10.2174/1389201015666141113123502info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/126090/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:43Zoai:ri.conicet.gov.ar:11336/28425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:44.095CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
title |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
spellingShingle |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model Saraiva, Tessália D. L. Colitis Fermented Milk Inflammation Lactic Acid Bacteria Lactococcus Lactis Lipoxygenase |
title_short |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
title_full |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
title_fullStr |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
title_full_unstemmed |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
title_sort |
Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model |
dc.creator.none.fl_str_mv |
Saraiva, Tessália D. L. Morais, Kátia Pereira, Vanessa B. de Azevedo, Marcela Santos Rocha, Clarissa Castro Prosperi, Camila Gomes Santos, Ana C. Bermudez Humaran, Luis Caetano Faria, Ana M. Blottiere, Hervé M. Langella, Philippe Miyoshi, Anderson de Moreno, Maria Alejandra Leblanc, Jean Guy Joseph Azevedo, Vasco |
author |
Saraiva, Tessália D. L. |
author_facet |
Saraiva, Tessália D. L. Morais, Kátia Pereira, Vanessa B. de Azevedo, Marcela Santos Rocha, Clarissa Castro Prosperi, Camila Gomes Santos, Ana C. Bermudez Humaran, Luis Caetano Faria, Ana M. Blottiere, Hervé M. Langella, Philippe Miyoshi, Anderson de Moreno, Maria Alejandra Leblanc, Jean Guy Joseph Azevedo, Vasco |
author_role |
author |
author2 |
Morais, Kátia Pereira, Vanessa B. de Azevedo, Marcela Santos Rocha, Clarissa Castro Prosperi, Camila Gomes Santos, Ana C. Bermudez Humaran, Luis Caetano Faria, Ana M. Blottiere, Hervé M. Langella, Philippe Miyoshi, Anderson de Moreno, Maria Alejandra Leblanc, Jean Guy Joseph Azevedo, Vasco |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Colitis Fermented Milk Inflammation Lactic Acid Bacteria Lactococcus Lactis Lipoxygenase |
topic |
Colitis Fermented Milk Inflammation Lactic Acid Bacteria Lactococcus Lactis Lipoxygenase |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules. Fil: Saraiva, Tessália D. L.. Universidade Federal do Minas Gerais; Brasil Fil: Morais, Kátia. Universidade Federal do Minas Gerais; Brasil Fil: Pereira, Vanessa B.. Universidade Federal do Minas Gerais; Brasil Fil: de Azevedo, Marcela. Universidade Federal do Minas Gerais; Brasil Fil: Santos Rocha, Clarissa. Universidade Federal do Minas Gerais; Brasil Fil: Castro Prosperi, Camila. Universidade Federal do Minas Gerais; Brasil Fil: Gomes Santos, Ana C.. Universidade Federal do Minas Gerais; Brasil Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia Fil: Caetano Faria, Ana M.. Universidade Federal do Minas Gerais; Brasil Fil: Blottiere, Hervé M.. Institut National de la Recherche Agronomique; Francia Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil |
description |
Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, is characterized by extensive inflammation due to dysregulation of the innate and adaptive immune system whose exact etiology is not yet completely understood. Currently there is no cure for IBD, thus the search for new molecules capable of controlling IBD and their delivery to the site of inflammation are the goal of many researchers. The aim of this work was to evaluate the anti-inflammatory effect of the administration of milks fermented by a Lactococcus (L.) lactis strain producing 15-lipoxygenase-1 (15-LOX-1) using a trinitrobenzenesulfonic acid-induced IBD mouse model. The results obtained demonstrated that 15-LOX-1 producing L. lactis was effective in the prevention of the intestinal damage associated to inflammatory bowel disease in a murine model. The work also confirmed previous studies showing that fermented milk is an effective form of administration of recombinant lactic acid bacteria expressing beneficial molecules. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/28425 Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-429 1389-2010 1873-4316 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/28425 |
identifier_str_mv |
Saraiva, Tessália D. L.; Morais, Kátia; Pereira, Vanessa B.; de Azevedo, Marcela; Santos Rocha, Clarissa; et al.; Milk fermented with a 15-lipoxygenase-1-producing lactococcus lactis alleviates symptoms of colitis in a murine model; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 5; 3-2015; 424-429 1389-2010 1873-4316 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/ 10.2174/1389201015666141113123502 info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/126090/article |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
publisher.none.fl_str_mv |
Bentham Science Publishers |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613998781136896 |
score |
13.070432 |